 Loperamide
"Loperamide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
| Descriptor ID |
D008139
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| MeSH Number(s) |
D03.383.621.440
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| Concept/Terms |
Loperamide Hydrochloride- Loperamide Hydrochloride
- Hydrochloride, Loperamide
- Loperamide Monohydrochloride
- Monohydrochloride, Loperamide
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Below are MeSH descriptors whose meaning is more general than "Loperamide".
Below are MeSH descriptors whose meaning is more specific than "Loperamide".
This graph shows the total number of publications written about "Loperamide" by people in this website by year, and whether "Loperamide" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2018 | 1 | 1 | 2 | | 2019 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 | | 2023 | 1 | 1 | 2 |
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Below are the most recent publications written about "Loperamide" by people in Profiles.
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Krantz MJ, Stockbridge N, Kao DP, Klein MG, Haigney MCP. Reply: Loperamide-Associated Ventricular Arrhythmias. J Am Coll Cardiol. 2023 10 24; 82(17):e159.
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Krantz MJ, Rudo TJ, Haigney MCP, Stockbridge N, Kleiman RB, Klein M, Kao DP. Ventricular Arrhythmias Associated With?Over-the-Counter and Recreational?Opioids. J Am Coll Cardiol. 2023 06 13; 81(23):2258-2268.
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Simon M, Rague J. A Case Report of Torsade de Pointes and Brugada Pattern Associated with Loperamide Misuse and Supratherapeutic Loperamide Concentrations. J Emerg Med. 2021 10; 61(4):e54-e59.
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Bugaev N, Bhattacharya B, Chiu WC, Como JJ, Cripps MW, Ferrada P, Gelbard RB, Gondek S, Kasotakis G, Kim D, Mentzer C, Robinson BRH, Salcedo ES, Yeh DD. Antimotility agents for the treatment of acute noninfectious diarrhea in critically ill patients: A practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2019 10; 87(4):915-921.
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Lee VR, Vera A, Alexander A, Ruck B, Nelson LS, Wax P, Campleman S, Brent J, Calello DP. Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk. Clin Toxicol (Phila). 2019 03; 57(3):175-180.
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Schletker J, Edmonds T, Jacobson R, Ketzer J, Hall J, Trecartin A, Pe?a A, Bischoff A. Bowel management program in patients with spina bifida. Pediatr Surg Int. 2019 Feb; 35(2):243-245.
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Haigney MC, Klein MG, Flagg TP, Fatima N, Mehler PS, Krantz MJ. Reply: Labeling and Drug Safety of Loperamide: Time for a Proactive Approach? JACC Clin Electrophysiol. 2017 04; 3(4):422-423.
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Jurgens PT, Allen LA, Ambardekar AV, McIlvennan CK. Chronic Norovirus Infections in Cardiac Transplant Patients. Prog Transplant. 2017 03; 27(1):69-72.
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Klein MG, Haigney MCP, Mehler PS, Fatima N, Flagg TP, Krantz MJ. Potent Inhibition of hERG Channels by the?Over-the-Counter Antidiarrheal Agent?Loperamide. JACC Clin Electrophysiol. 2016 12; 2(7):784-789.
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Elkiweri IA, Zhang YL, Christians U, Ng KY, Tissot van Patot MC, Henthorn TK. Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats. Anesth Analg. 2009 Jan; 108(1):149-59.
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