 Extracellular Matrix
"Extracellular Matrix" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
| Descriptor ID |
D005109
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| MeSH Number(s) |
A11.284.295.310
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| Concept/Terms |
Extracellular Matrix- Extracellular Matrix
- Matrix, Extracellular
- Extracellular Matrices
- Matrices, Extracellular
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Below are MeSH descriptors whose meaning is more general than "Extracellular Matrix".
Below are MeSH descriptors whose meaning is more specific than "Extracellular Matrix".
This graph shows the total number of publications written about "Extracellular Matrix" by people in this website by year, and whether "Extracellular Matrix" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 | | 1997 | 3 | 1 | 4 | | 2000 | 1 | 2 | 3 | | 2001 | 1 | 2 | 3 | | 2002 | 2 | 0 | 2 | | 2003 | 3 | 5 | 8 | | 2004 | 2 | 7 | 9 | | 2005 | 3 | 6 | 9 | | 2006 | 5 | 5 | 10 | | 2007 | 3 | 2 | 5 | | 2008 | 5 | 7 | 12 | | 2009 | 10 | 8 | 18 | | 2010 | 3 | 5 | 8 | | 2011 | 4 | 11 | 15 | | 2012 | 8 | 6 | 14 | | 2013 | 4 | 9 | 13 | | 2014 | 8 | 11 | 19 | | 2015 | 8 | 6 | 14 | | 2016 | 13 | 11 | 24 | | 2017 | 8 | 11 | 19 | | 2018 | 11 | 10 | 21 | | 2019 | 10 | 9 | 19 | | 2020 | 6 | 16 | 22 | | 2021 | 8 | 10 | 18 | | 2022 | 2 | 15 | 17 | | 2023 | 1 | 10 | 11 | | 2024 | 5 | 13 | 18 | | 2025 | 9 | 12 | 21 | | 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Extracellular Matrix" by people in Profiles.
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Grandke F, Rishik S, Wagner V, Engel A, Ludwig N, Calcuttawala K, Kern F, Keller V, Krawczyk M, Stodieck L, Ferguson V, Roberts A, Meese E, Schaum N, Quake S, Wyss-Coray T, Keller A. MiRNAs shape mouse age-independent tissue adaptation to spaceflight via ECM and developmental pathways. Nat Commun. 2026 Feb 05; 17(1):1387.
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Reeser RS, VeDepo MC, Hewawasam RS, Waugh KA, Schade KA, Abdel-Hafiz M, Peña B, Mestroni L, Sbaizero O, Espinosa JM, Magin CM, Jacot JG. Aberrant tissue mechanics and mechanotransduction during heart development in down syndrome. J Biomech. 2026 Jan; 195:113103.
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Ginocchio S, McCabe MC, Flockton AR, Gumina DL, Hansen KC, Ji S, Su EJ. Unraveling the Matrix: Proteomic Profiling Reveals Stromal ECM Dysregulation in Severe Early-Onset Fetal Growth Restriction. Int J Mol Sci. 2025 Nov 19; 26(22).
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Schott CA, Redente EF. Pathogenic expansion: fibroblast proliferation fuels fibrosis. J Clin Invest. 2025 Nov 17; 135(22).
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Calo CJ, Radke M, Patil T, Hind LE. Regulation of neutrophil function by the extracellular matrix. Biochem Soc Trans. 2025 Oct 29; 53(5):1325-1336.
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Ibrahim SY, Holdiness R, Thadisena A, Boyle KE, Jun SR, Bagchi RA. 3-D biomechanics and epigenomics reveal atypical fibroblast responses in cardiometabolic disease. Am J Physiol Heart Circ Physiol. 2025 Nov 01; 329(5):H1267-H1277.
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Johansen CG, Lam K, Farnsworth NL. Stressed ß-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes. Front Endocrinol (Lausanne). 2025; 16:1675043.
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Locke RC, Miller LM, Lemmon EA, Assi SS, Jones DL, Bonnevie ED, Burdick JA, Heo SJ, Mauck RL. Rapid restoration of cell phenotype and matrix forming capacity following transient nuclear softening. Acta Biomater. 2025 Dec; 208:336-349.
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Nishida-Aoki N, Zhu S, Chan M, Kang Y, Fujita M, Jiang X, McCabe M, Vaz JM, Davidson NE, Ghajar CM, Hansen K, Welm AL, Pillarisetty VG, Gujral TS. Drug screening in 3D microtumors reveals DDR1/2-MAPK12-GLI1 as a vulnerability in cancer-associated fibroblasts. Cell Rep Med. 2025 Oct 21; 6(10):102357.
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Cardaci TD, Bastian AV, Roark K, Bullard BM, NeSmith MM, Unger CA, Price RL, Kubinak JL, Murphy EA, VanderVeen BN. Profibrotic immune cells and fibro-adipogenic progenitors contribute to skeletal muscle extracellular matrix remodeling and fibrosis in cancer cachexia. Am J Physiol Cell Physiol. 2025 Oct 01; 329(4):C1283-C1299.
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