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David H Root

TitleAssistant Professor
InstitutionUniversity of Colorado Boulder
DepartmentPsych-Psychology

    Collapse Research 
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    R01MH137472     (ROOT, DAVID H)Jul 3, 2024 - Feb 28, 2029
    NIH
    Untangling dopamine and glutamate neuron function in the VTA
    Role: Principal Investigator
    R01MH130576     (ROOT, DAVID H)Apr 22, 2024 - Jan 31, 2029
    NIH
    Circuits and neurotransmitters involved in VTA glutamate neuron regulation of the consequences of stress
    Role: Principal Investigator
    R01DA047443     (ROOT, DAVID H)Apr 1, 2020 - Jan 31, 2025
    NIH
    Genetic dissection of ventral tegmental area glutamate and GABA neurons in reward and aversion
    Role: Principal Investigator
    F31DA026252     (ROOT, DAVID H)May 25, 2009 - May 24, 2012
    NIH
    Neurophysiology of cocaine-seeking behavior
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Stritzel WJ, Levy C, Ravenel JR, Strnad HK, Osman M, Pr?vost ED, Root DH, Reuter JD, Sloan AM, Spencer RL. Red Light Sensitivity of Non-image and Image Forming Visual Systems of Laboratory Rodents: Circadian Disruption and Behavioral Detection. J Neurosci. 2025 May 14; 45(20). PMID: 40204436.
      View in: PubMed
    2. Ly A, Hotchkiss H, Pr?vost ED, Pelletier JM, Deming MA, Murib L, Root DH. Assessing the role of BNST GABA neurons in backward conditioned suppression. Neurobiol Learn Mem. 2025 May; 219:108058. PMID: 40318802.
      View in: PubMed
    3. Pr?vost ED, Root DH. Indirect, but not direct, lateral habenula projections to ventral tegmental area regulate the long-term consequences of neuropathic pain. Neuropsychopharmacology. 2025 Jun; 50(7):1025-1026. PMID: 40263415.
      View in: PubMed
    4. Pr?vost ED, Ward LA, Alas D, Aimale G, Ikenberry S, Fox K, Pelletier J, Ly A, Ball J, Kilpatrick ZP, Price K, Polter AM, Root DH. Untangling dopamine and glutamate in the ventral tegmental area. bioRxiv. 2025 Feb 26. PMID: 40060543.
      View in: PubMed
    5. Ly A, Karnosky R, Pr?vost ED, Hotchkiss H, Pelletier J, Spencer RL, Ford CP, Root DH. VGluT3 BNST neurons transmit GABA and restrict feeding without affecting rewarding or aversive processing. bioRxiv. 2025 Jan 02. PMID: 39803518.
      View in: PubMed
    6. Ly A, Hotchkiss H, Pr?vost ED, Pelletier J, Deming M, Murib L, Root DH. Assessing the role of BNST GABA neurons in backward conditioned suppression. bioRxiv. 2025 Jan 02. PMID: 39803568.
      View in: PubMed
    7. Pr?vost ED, Phillips A, Lauridsen K, Enserro G, Rubinstein B, Alas D, McGovern DJ, Ly A, Hotchkiss H, Banks M, McNulty C, Kim YS, Fenno LE, Ramakrishnan C, Deisseroth K, Root DH. Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons. J Neurosci. 2024 Nov 13; 44(46). PMID: 39327007.
      View in: PubMed
    8. Vijay V, Karisani N, Shi L, Hung YH, Vu P, Kattel P, Kenney L, Merritt J, Adil R, Wu Q, Zhen Y, Morris R, Kreuzer J, Kathiresan M, Herrera Lopez XI, Ellis H, Gritti I, Lecorgne L, Farag I, Popa A, Shen W, Kato H, Xu Q, Balasooriya ER, Wu MJ, Chaturantabut S, Kelley RK, Cleary JM, Lawrence MS, Root D, Benes CH, Deshpande V, Juric D, Sellers WR, Ferrone CR, Haas W, Vazquez F, Getz G, Bardeesy N. Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets. bioRxiv. 2024 Jul 08. PMID: 39026794.
      View in: PubMed
    9. McGovern DJ, Phillips A, Ly A, Pr?vost ED, Ward L, Siletti K, Kim YS, Fenno LE, Ramakrishnan C, Deisseroth K, Ford CP, Root DH. Salience signaling and stimulus scaling of ventral tegmental area glutamate neuron subtypes. bioRxiv. 2024 Jun 12. PMID: 38915564.
      View in: PubMed
    10. Pr?vost ED, Phillips A, Lauridsen K, Enserro G, Rubinstein B, Alas D, McGovern DJ, Ly A, Banks M, McNulty C, Kim YS, Fenno LE, Ramakrishnan C, Deisseroth K, Root DH. Monosynaptic inputs to ventral tegmental area glutamate and GABA co-transmitting neurons. bioRxiv. 2023 Nov 21. PMID: 37066408.
      View in: PubMed
    11. Ly A, Barker A, Hotchkiss H, Pr?vost ED, McGovern DJ, Kilpatrick Z, Root DH. Bed nucleus of the stria terminalis GABA neurons are necessary for changes in foraging behaviour following an innate threat. Eur J Neurosci. 2023 10; 58(7):3630-3649. PMID: 37715507.
      View in: PubMed
    12. Ball JB, McNulty CJ, Green-Fulgham SM, Dragavon JM, Correia Rocha IR, Finch MR, Pr?vost ED, Siddique II, Woodall BJ, Watkins LR, Baratta MV, Root DH. Combining RNAscope and immunohistochemistry to visualize inflammatory gene products in neurons and microglia. Front Mol Neurosci. 2023; 16:1225847. PMID: 37664240.
      View in: PubMed
    13. McGovern DJ, Polter AM, Pr?vost ED, Ly A, McNulty CJ, Rubinstein B, Root DH. Ventral tegmental area glutamate neurons establish a mu-opioid receptor gated circuit to mesolimbic dopamine neurons and regulate opioid-seeking behavior. Neuropsychopharmacology. 2023 12; 48(13):1889-1900. PMID: 37407648.
      View in: PubMed
    14. Ly A, Barker A, Pr?vost ED, McGovern DJ, Kilpatrick Z, Root DH. Bed Nucleus of the Stria Terminalis GABA neurons are necessary for changes in foraging behavior following an innate threat. bioRxiv. 2023 Feb 25. PMID: 36865159.
      View in: PubMed
    15. McGovern DJ, Ly A, Ecton KL, Huynh DT, Pr?vost ED, Gonzalez SC, McNulty CJ, Rau AR, Hentges ST, Daigle TL, Tasic B, Baratta MV, Root DH. Ventral tegmental area glutamate neurons mediate nonassociative consequences of stress. Mol Psychiatry. 2024 Jun; 29(6):1671-1682. PMID: 36437312.
      View in: PubMed
    16. McNulty CJ, Fallon IP, Amat J, Sanchez RJ, Leslie NR, Root DH, Maier SF, Baratta MV. Elevated prefrontal dopamine interferes with the stress-buffering properties of behavioral control in female rats. Neuropsychopharmacology. 2023 02; 48(3):498-507. PMID: 36076018.
      View in: PubMed
    17. Lauridsen K, Ly A, Pr?vost ED, McNulty C, McGovern DJ, Tay JW, Dragavon J, Root DH. A Semi-Automated Workflow for Brain Slice Histology Alignment, Registration, and Cell Quantification (SHARCQ). eNeuro. 2022 Mar-Apr; 9(2). PMID: 35396257.
      View in: PubMed
    18. Ly A, Root DH. Neuromedin U: a neuropeptide modulator of GABA transmission contributes to cocaine seeking. Neuropsychopharmacology. 2022 10; 47(11):1873-1874. PMID: 34949771.
      View in: PubMed
    19. McGovern DJ, Polter AM, Root DH. Neurochemical Signaling of Reward and Aversion to Ventral Tegmental Area Glutamate Neurons. J Neurosci. 2021 06 23; 41(25):5471-5486. PMID: 34001626.
      View in: PubMed
    20. Root DH, Barker DJ, Estrin DJ, Miranda-Barrientos JA, Liu B, Zhang S, Wang HL, Vautier F, Ramakrishnan C, Kim YS, Fenno L, Deisseroth K, Morales M. Distinct Signaling by Ventral Tegmental Area Glutamate, GABA, and Combinatorial Glutamate-GABA Neurons in Motivated Behavior. Cell Rep. 2020 09 01; 32(9):108094. PMID: 32877676.
      View in: PubMed
    21. McGovern DJ, Root DH. Ventral pallidum: a promising target for addiction intervention. Neuropsychopharmacology. 2019 12; 44(13):2151-2152. PMID: 31558771.
      View in: PubMed
    22. Phillips AG, McGovern DJ, Lee S, Ro K, Huynh DT, Elvig SK, Fegan KN, Root DH. Oral prescription opioid-seeking behavior in male and female mice. Addict Biol. 2020 11; 25(6):e12828. PMID: 31489746.
      View in: PubMed
    23. Root DH, Zhang S, Barker DJ, Miranda-Barrientos J, Liu B, Wang HL, Morales M. Selective Brain Distribution and Distinctive Synaptic Architecture of Dual Glutamatergic-GABAergic Neurons. Cell Rep. 2018 06 19; 23(12):3465-3479. PMID: 29924991.
      View in: PubMed
    24. Root DH, Estrin DJ, Morales M. Aversion or Salience Signaling by Ventral Tegmental Area Glutamate Neurons. iScience. 2018 Apr 27; 2:51-62. PMID: 29888759.
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    25. Barker DJ, Miranda-Barrientos J, Zhang S, Root DH, Wang HL, Liu B, Calipari ES, Morales M. Lateral Preoptic Control of the Lateral Habenula through Convergent Glutamate and GABA Transmission. Cell Rep. 2017 Nov 14; 21(7):1757-1769. PMID: 29141211.
      View in: PubMed
    26. Zahm DS, Root DH. Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving. Pharmacol Biochem Behav. 2017 Nov; 162:3-21. PMID: 28647565.
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    27. Root DH, Wang HL, Liu B, Barker DJ, M?d L, Szocsics P, Silva AC, Magl?czky Z, Morales M. Glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans. Sci Rep. 2016 08 01; 6:30615. PMID: 27477243.
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    28. Barker DJ, Root DH, Zhang S, Morales M. Multiplexed neurochemical signaling by neurons of the ventral tegmental area. J Chem Neuroanat. 2016 Apr; 73:33-42. PMID: 26763116.
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    29. Root DH, Melendez RI, Zaborszky L, Napier TC. The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors. Prog Neurobiol. 2015 Jul; 130:29-70. PMID: 25857550.
      View in: PubMed
    30. Root DH, Hoffman AF, Good CH, Zhang S, Gigante E, Lupica CR, Morales M. Norepinephrine activates dopamine D4 receptors in the rat lateral habenula. J Neurosci. 2015 Feb 25; 35(8):3460-9. PMID: 25716845.
      View in: PubMed
    31. Root DH, Mejias-Aponte CA, Qi J, Morales M. Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning. J Neurosci. 2014 Oct 15; 34(42):13906-10. PMID: 25319687.
      View in: PubMed
    32. Root DH, Mejias-Aponte CA, Zhang S, Wang HL, Hoffman AF, Lupica CR, Morales M. Single rodent mesohabenular axons release glutamate and GABA. Nat Neurosci. 2014 Nov; 17(11):1543-51. PMID: 25242304.
      View in: PubMed
    33. Morales M, Root DH. Glutamate neurons within the midbrain dopamine regions. Neuroscience. 2014 Dec 12; 282:60-8. PMID: 24875175.
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    34. Striano BM, Barker DJ, Pawlak AP, Root DH, Fabbricatore AT, Coffey KR, Stamos JP, West MO. Olfactory tubercle neurons exhibit slow-phasic firing patterns during cocaine self-administration. Synapse. 2014 Jul; 68(7):321-3. PMID: 24700541.
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    35. Barker DJ, Striano BM, Coffey KC, Root DH, Pawlak AP, Kim OA, Kulik J, Fabbricatore AT, West MO. Sensitivity to self-administered cocaine within the lateral preoptic-rostral lateral hypothalamic continuum. Brain Struct Funct. 2015; 220(3):1841-54. PMID: 24604249.
      View in: PubMed
    36. Barker DJ, Root DH, Coffey KR, Ma S, West MO. A procedure for implanting organized arrays of microwires for single-unit recordings in awake, behaving animals. J Vis Exp. 2014 Feb 14; (84):e51004. PMID: 24561332.
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    37. Root DH. The ventromedial ventral pallidum subregion is necessary for outcome-specific Pavlovian-instrumental transfer. J Neurosci. 2013 Nov 27; 33(48):18707-9. PMID: 24285876.
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    38. Barker DJ, Simmons SJ, Servilio LC, Bercovicz D, Ma S, Root DH, Pawlak AP, West MO. Ultrasonic vocalizations: evidence for an affective opponent process during cocaine self-administration. Psychopharmacology (Berl). 2014 Mar; 231(5):909-18. PMID: 24197178.
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    39. Barker DJ, Bercovicz D, Servilio LC, Simmons SJ, Ma S, Root DH, Pawlak AP, West MO. Rat ultrasonic vocalizations demonstrate that the motivation to contextually reinstate cocaine-seeking behavior does not necessarily involve a hedonic response. Addict Biol. 2014 Sep; 19(5):781-90. PMID: 23506088.
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    40. Root DH, Ma S, Barker DJ, Megehee L, Striano BM, Ralston CM, Fabbricatore AT, West MO. Differential roles of ventral pallidum subregions during cocaine self-administration behaviors. J Comp Neurol. 2013 Feb 15; 521(3):558-88. PMID: 22806483.
      View in: PubMed
    41. Ma S, Pawlak AP, Cho J, Root DH, Barker DJ, West MO. Amphetamine's dose-dependent effects on dorsolateral striatum sensorimotor neuron firing. Behav Brain Res. 2013 May 01; 244:152-61. PMID: 23396149.
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    42. Coffey KR, Barker DJ, Ma S, Root DH, Martinez L, Horvitz JC, West MO. Effects of varying reinforcement probability on pavlovian approach behavior and ultrasonic vocalizations in rats. Behav Brain Res. 2013 Jan 15; 237:256-62. PMID: 23022752.
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    43. Root DH, Fabbricatore AT, Pawlak AP, Barker DJ, Ma S, West MO. Slow phasic and tonic activity of ventral pallidal neurons during cocaine self-administration. Synapse. 2012 Feb; 66(2):106-27. PMID: 21953543.
      View in: PubMed
    44. McGinty VB, Hayden BY, Heilbronner SR, Dumont EC, Graves SM, Mirrione MM, du Hoffmann J, Sartor GC, Espa?a RA, Millan EZ, Difeliceantonio AG, Marchant NJ, Napier TC, Root DH, Borgland SL, Treadway MT, Floresco SB, McGinty JF, Haber S. Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference. Behav Brain Res. 2011 Nov 20; 225(1):348-57. PMID: 21816177.
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    45. Root DH, Barker DJ, Ma S, Coffey KR, Fabbricatore AT, West MO. Evidence for learned skill during cocaine self-administration in rats. Psychopharmacology (Berl). 2011 Sep; 217(1):91-100. PMID: 21455708.
      View in: PubMed
    46. Root DH, Fabbricatore AT, Ma S, Barker DJ, West MO. Rapid phasic activity of ventral pallidal neurons during cocaine self-administration. Synapse. 2010 Sep; 64(9):704-13. PMID: 20340176.
      View in: PubMed
    47. Barker DJ, Root DH, Ma S, Jha S, Megehee L, Pawlak AP, West MO. Dose-dependent differences in short ultrasonic vocalizations emitted by rats during cocaine self-administration. Psychopharmacology (Berl). 2010 Sep; 211(4):435-42. PMID: 20571780.
      View in: PubMed
    48. Root DH, Tang CC, Ma S, Pawlak AP, West MO. Absence of cue-evoked firing in rat dorsolateral striatum neurons. Behav Brain Res. 2010 Jul 29; 211(1):23-32. PMID: 20211654.
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    49. Tang CC, Root DH, Duke DC, Zhu Y, Teixeria K, Ma S, Barker DJ, West MO. Decreased firing of striatal neurons related to licking during acquisition and overtraining of a licking task. J Neurosci. 2009 Nov 04; 29(44):13952-61. PMID: 19890005.
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    50. Root DH, Fabbricatore AT, Barker DJ, Ma S, Pawlak AP, West MO. Evidence for habitual and goal-directed behavior following devaluation of cocaine: a multifaceted interpretation of relapse. PLoS One. 2009 Sep 25; 4(9):e7170. PMID: 19779607.
      View in: PubMed
    51. Root DH, Barker DJ, Ma S. Duality of salience in dopamine neurons. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):E84. PMID: 19628687.
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    52. Silvestri AJ, Root DH. Effects of REM deprivation and an NMDA agonist on the extinction of conditioned fear. Physiol Behav. 2008 Jan 28; 93(1-2):274-81. PMID: 17920644.
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    53. Root DH. Letter regarding: Fisk, D.J. (2004). Bacon, Boole, Popper. Risk Analysis, 24(5), 1097-1098. Risk Anal. 2005 Apr; 25(2):229. PMID: 15876199.
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    54. Root DH. Bacon, Boole, the EPA, and scientific standards. Risk Anal. 2003 Aug; 23(4):663-8. PMID: 12926560.
      View in: PubMed
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