Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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John Philip Mayer

TitleResearch Associate
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sanner K, Kawell S, Evans JG, Elekovic V, Walz M, Joksimovic SL, Joksimovic SM, Donald RR, Tomic M, Orestes P, Feseha S, Dedek A, Ghodsi SM, Fallon IP, Lee J, Hwang SM, Hong SJ, Mayer JP, Covey DF, Romano C, Timic Stamenic T, Chemin J, Bourinet E, Poulen G, Longon N, Vachiery-Lahaye F, Bauchet L, Zorumski CF, Stowell MHB, Hildebrand ME, Eisenmesser EZ, Jevtovic-Todorovic V, Todorovic SM. Facilitation of Ca V 3.2 channel gating in pain pathways reveals a novel mechanism of serum-induced hyperalgesia. bioRxiv. 2025 Jan 16. PMID: 39868306.
      View in: PubMed
    2. Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E. Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun. 2022 09 23; 13(1):5594. PMID: 36151101.
      View in: PubMed
    3. Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC. Synergistic activation of the insulin receptor via two distinct sites. Nat Struct Mol Biol. 2022 04; 29(4):357-368. PMID: 35361965.
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    4. He R, Mowery SA, Chabenne J, Finan B, Mayer JP, DiMarchi RD. A Facile Procedure for One-Pot Stable Conjugation of Two Proglucagon Cysteine-Containing Peptide Analogs. Front Endocrinol (Lausanne). 2021; 12:693958. PMID: 34484114.
      View in: PubMed
    5. DiMarchi RD, Mayer JP. Icodec Advances the Prospect of Once-Weekly Insulin Injection. J Med Chem. 2021 07 08; 64(13):8939-8941. PMID: 34133152.
      View in: PubMed
    6. Yang B, Gelfanov VM, Perez-Tilve D, DuBois B, Rohlfs R, Levy J, Douros JD, Finan B, Mayer JP, DiMarchi RD. Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists. J Med Chem. 2021 04 22; 64(8):4697-4708. PMID: 33821647.
      View in: PubMed
    7. Kabotso DEK, Smiley D, Mayer JP, Gelfanov VM, Perez-Tilve D, DiMarchi RD, Pohl NLB, Liu F. Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence. J Med Chem. 2020 06 11; 63(11):6134-6143. PMID: 32406685.
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    8. Brunel FM, Mayer JP, DiMarchi RD. Recent advances in the chemical synthesis of insulin and related peptides. Future Med Chem. 2020 04; 12(8):649-654. PMID: 32180453.
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    9. He R, Pan J, Mayer JP, Liu F. Stepwise Construction of Disulfides in Peptides. Chembiochem. 2020 04 17; 21(8):1101-1111. PMID: 31886929.
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    10. Chabenne JR, Mroz PA, Mayer JP, DiMarchi RD. Structural Refinement of Glucagon for Therapeutic Use. J Med Chem. 2020 04 09; 63(7):3447-3460. PMID: 31774682.
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    11. Brunel FM, Mayer JP, Gelfanov VM, Zaykov AN, Finan B, Perez-Tilve D, DiMarchi RD. A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity. ACS Chem Biol. 2019 08 16; 14(8):1829-1835. PMID: 31343157.
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    12. He R, Finan B, Mayer JP, DiMarchi RD. Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety. Molecules. 2019 May 14; 24(10). PMID: 31091786.
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    13. Brandt SJ, Mayer JP, Ford J, Gelfanov VM, DiMarchi RD. Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity. Peptides. 2018 02; 100:18-23. PMID: 29412818.
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    14. Zhang F, Mayer JP, Gelfanov V, Liu F, DiMarchi RD. Structurally Constrained Insulin Analogs by Directed Stepwise Crosslinking. Protein Pept Lett. 2018; 25(12):1149-1154. PMID: 30381053.
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    15. DiMarchi RD, Mayer JP, Gelfanov VM, Tschöp M. Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases. J Pept Sci. 2018 Jan; 24(1). PMID: 29322647.
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    16. Adams DJ, Nemkov TG, Mayer JP, Old WM, Stowell MHB. Identification of the primary peptide contaminant that inhibits fibrillation and toxicity in synthetic amyloid-ß42. PLoS One. 2017; 12(8):e0182804. PMID: 28792968.
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    17. Mayer JP, Tschöp MH, DiMarchi RD. Once Blind, Now We See GLP-1 Molecular Action. Cell Metab. 2017 08 01; 26(2):289-291. PMID: 28768169.
      View in: PubMed
    18. Thalluri K, Kou B, Yang X, Zaykov AN, Mayer JP, Gelfanov VM, Liu F, DiMarchi RD. Synthesis of relaxin-2 and insulin-like peptide 5 enabled by novel tethering and traceless chemical excision. J Pept Sci. 2017 Jun; 23(6):455-465. PMID: 28466571.
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    19. Wu F, Mayer JP, Gelfanov VM, Liu F, DiMarchi RD. Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation. J Org Chem. 2017 04 07; 82(7):3506-3512. PMID: 28319665.
      View in: PubMed
    20. Thalluri K, Kou B, Gelfanov V, Mayer JP, Liu F, DiMarchi RD. Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless "C-Peptide" Chemical Excision. Org Lett. 2017 02 03; 19(3):706-709. PMID: 28124920.
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    21. Mroz PA, Perez-Tilve D, Liu F, Mayer JP, DiMarchi RD. Native Design of Soluble, Aggregation-Resistant Bioactive Peptides: Chemical Evolution of Human Glucagon. ACS Chem Biol. 2016 12 16; 11(12):3412-3420. PMID: 27797473.
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    22. Mroz PA, Perez-Tilve D, Liu F, Gelfanov V, DiMarchi RD, Mayer JP. Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization. J Med Chem. 2016 09 08; 59(17):8061-7. PMID: 27509198.
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    23. Wu F, Mayer JP, Zaykov AN, Zhang F, Liu F, DiMarchi RD. Chemical Synthesis of Human Insulin-Like Peptide-6. Chemistry. 2016 Jul 04; 22(28):9777-83. PMID: 27259101.
      View in: PubMed
    24. Zaykov AN, Mayer JP, DiMarchi RD. Pursuit of a perfect insulin. Nat Rev Drug Discov. 2016 06; 15(6):425-39. PMID: 26988411.
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    25. Liu F, Zaykov AN, Levy JJ, DiMarchi RD, Mayer JP. Chemical synthesis of peptides within the insulin superfamily. J Pept Sci. 2016 May; 22(5):260-70. PMID: 26910514.
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    26. Horness RE, Basom EJ, Mayer JP, Thielges MC. Resolution of Site-Specific Conformational Heterogeneity in Proline-Rich Molecular Recognition by Src Homology 3 Domains. J Am Chem Soc. 2016 Feb 03; 138(4):1130-3. PMID: 26784847.
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    27. Wu F, Chabenne JR, Gelfanov VM, Mayer JP, DiMarchi RD. Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity. J Pept Sci. 2015 Mar; 21(3):223-30. PMID: 25665061.
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    28. Zaykov AN, Mayer JP, Gelfanov VM, DiMarchi RD. Chemical synthesis of insulin analogs through a novel precursor. ACS Chem Biol. 2014 Mar 21; 9(3):683-91. PMID: 24328449.
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    29. Liu F, Mayer JP. An Fmoc compatible, O to S shift-mediated procedure for the preparation of C-terminal thioester peptides. J Org Chem. 2013 Oct 04; 78(19):9848-56. PMID: 24000771.
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    30. Kaur ZP, Ochman AR, Mayer JP, Gelfanov VM, DiMarchi RD. Discovery of high potency, single-chain insulin analogs with a shortened B-chain and nonpeptide linker. ACS Chem Biol. 2013 Aug 16; 8(8):1822-9. PMID: 23730814.
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    31. Liu F, Luo EY, Flora DB, Mayer JP. Concise synthetic routes to human insulin. Org Lett. 2013 Feb 15; 15(4):960-3. PMID: 23391097.
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    32. Kohn WD, Micanovic R, Myers SL, Vick AM, Kahl SD, Zhang L, Strifler BA, Li S, Shang J, Beals JM, Mayer JP, DiMarchi RD. pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity. Peptides. 2007 Apr; 28(4):935-48. PMID: 17328992.
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    33. Mayer JP, Zhang F, DiMarchi RD. Insulin structure and function. Biopolymers. 2007; 88(5):687-713. PMID: 17410596.
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    34. Yan LZ, Hsiung HM, Heiman ML, Gadski RA, Emmerson PJ, Hertel J, Flora D, Edwards P, Smiley D, Zhang L, Husain S, Kahl SD, DiMarchi RD, Mayer JP. Structure-activity relationships of beta-MSH derived melanocortin-4 receptor peptide agonists. Curr Top Med Chem. 2007; 7(11):1052-67. PMID: 17584126.
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    35. Yan LZ, Flora D, Edwards P, Smiley DL, Emmerson PJ, Hsiung HM, Gadski R, Hertel J, Heiman ML, Husain S, O'Brien TP, Kahl SD, Zhang L, Dimarchi RD, Mayer JP. Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold. Bioorg Med Chem Lett. 2005 Oct 15; 15(20):4611-4. PMID: 16105738.
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    36. Hsiung HM, Hertel J, Zhang XY, Smith DP, Smiley DL, Heiman ML, Yang DD, Husain S, Mayer JP, Zhang L, Mo H, Yan LZ. A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats. Endocrinology. 2005 Dec; 146(12):5257-66. PMID: 16166226.
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    37. Mayer JP, Dimarchi RD. Drugging the undruggable. Chem Biol. 2005 Aug; 12(8):860-1. PMID: 16125095.
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    38. Mayer JP, Hsiung HM, Flora DB, Edwards P, Smith DP, Zhang XY, Gadski RA, Heiman ML, Hertel JL, Emmerson PJ, Husain S, O'brien TP, Kahl SD, Smiley DL, Zhang L, Dimarchi RD, Yan LZ. Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 05; 48(9):3095-8. PMID: 15857110.
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