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Lauren A Vanderlinden

TitlePost-Doctoral Fellow
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-3626

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Harrall KK, Glueck DH, Lange LA, Litkowski EM, Vanderlinden LA, Konigsberg IR, Cree MG, Perng W, Dabelea D. GLP-1R gene polymorphisms and metabolic traits during childhood and adolescence: The EPOCH study. J Clin Endocrinol Metab. 2024 Dec 18. PMID: 39693247.
      View in: PubMed
    2. Townsend HA, Rosenberger KJ, Vanderlinden LA, Inamo J, Zhang F. Evaluating methods for integrating single-cell data and genetics to understand inflammatory disease complexity. Front Immunol. 2024; 15:1454263. PMID: 39703500.
      View in: PubMed
    3. Aldrich JC, Vanderlinden LA, Jacobsen TL, Wood C, Saba LM, Britt SG. Genome-Wide Association Study and transcriptome analysis reveals a complex gene network that regulates opsin gene expression and cell fate determination in Drosophila R7 photoreceptor cells. bioRxiv. 2024 Aug 07. PMID: 39149333.
      View in: PubMed
    4. Harrall KK, Bird SM, Muller KE, Vanderlinden LA, Payton ME, Bellatorre A, Dabelea D, Glueck DH. A better performing algorithm for identification of implausible growth data from longitudinal pediatric medical records. Sci Rep. 2024 08 06; 14(1):18276. PMID: 39107468.
      View in: PubMed
    5. Carry PM, Vanderlinden LA, Johnson RK, Buckner T, Steck AK, Kechris K, Yang IV, Fingerlin TE, Fiehn O, Rewers M, Norris JM. Longitudinal changes in DNA methylation during the onset of islet autoimmunity differentiate between reversion versus progression of islet autoimmunity. Front Immunol. 2024; 15:1345494. PMID: 38915393.
      View in: PubMed
    6. James EA, Holers VM, Iyer R, Prideaux EB, Rao NL, Rims C, Muir VS, Posso SE, Bloom MS, Zia A, Elliott SE, Adamska JZ, Ai R, Brewer RC, Seifert JA, Moss L, Barzideh S, Demoruelle MK, Striebich CC, Okamoto Y, Sainbayar E, Crook AA, Peterson RA, Vanderlinden LA, Wang W, Boyle DL, Robinson WH, Buckner JH, Firestein GS, Deane KD. Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis. Nat Commun. 2023 11 22; 14(1):7637. PMID: 37993439.
      View in: PubMed
    7. Johnson RK, Ireton AJ, Carry PM, Vanderlinden LA, Dong F, Romero A, Johnson DR, Ghosh D, Yang F, Frohnert B, Yang IV, Kechris K, Rewers M, Norris JM. DNA Methylation Near DLGAP2 May Mediate the Relationship between Family History of Type 1 Diabetes and Type 1 Diabetes Risk. Pediatr Diabetes. 2023; 2023. PMID: 38765731.
      View in: PubMed
    8. Elhassan S, Dong F, Buckner T, Johnson RK, Seifert JA, Carry PM, Vanderlinden L, Waugh K, Rewers M, Norris JM. Investigating iron intake in risk of progression from islet autoimmunity to type 1 diabetes: The diabetes autoimmunity study in the young. Front Immunol. 2023; 14:1124370. PMID: 37056761.
      View in: PubMed
    9. Buckner T, Johnson RK, Vanderlinden LA, Carry PM, Romero A, Onengut-Gumuscu S, Chen WM, Kim S, Fiehn O, Frohnert BI, Crume T, Perng W, Kechris K, Rewers M, Norris JM. Genome-wide analysis of oxylipins and oxylipin profiles in a pediatric population. Front Nutr. 2023; 10:1040993. PMID: 37057071.
      View in: PubMed
    10. Carry PM, Vigers T, Vanderlinden LA, Keeter C, Dong F, Buckner T, Litkowski E, Yang I, Norris JM, Kechris K. Propensity scores as a novel method to guide sample allocation and minimize batch effects during the design of high throughput experiments. BMC Bioinformatics. 2023 Mar 07; 24(1):86. PMID: 36882691.
      View in: PubMed
    11. Buckner T, Johnson RK, Vanderlinden LA, Carry PM, Romero A, Onengut-Gumuscu S, Chen WM, Fiehn O, Frohnert BI, Crume T, Perng W, Kechris K, Rewers M, Norris JM. An Oxylipin-Related Nutrient Pattern and Risk of Type 1 Diabetes in the Diabetes Autoimmunity Study in the Young (DAISY). Nutrients. 2023 Feb 14; 15(4). PMID: 36839302.
      View in: PubMed
    12. Brice AN, Vanderlinden LA, Marker KM, Mayer D, Lin M, Rafaels N, Shortt JA, Romero A, Lowery JT, Gignoux CR, Johnson RK. COVID-19 Mortality in the Colorado Center for Personalized Medicine Biobank. Int J Environ Res Public Health. 2023 01 29; 20(3). PMID: 36767733.
      View in: PubMed
    13. Booher WC, Vanderlinden LA, Hall LA, Thomas AL, Evans LM, Saba LM, Ehringer MA. Hippocampal RNA sequencing in mice selectively bred for high and low activity. Genes Brain Behav. 2023 04; 22(2):e12832. PMID: 36514243.
      View in: PubMed
    14. Pattee J, Vanderlinden LA, Mahaffey S, Hoffman P, Tabakoff B, Saba LM. Evaluation and characterization of expression quantitative trait analysis methods in the Hybrid Rat Diversity Panel. Front Genet. 2022; 13:947423. PMID: 36186443.
      View in: PubMed
    15. Carry PM, Waugh K, Vanderlinden LA, Johnson RK, Buckner T, Rewers M, Steck AK, Yang I, Fingerlin TE, Kechris K, Norris JM. Changes in the Coexpression of Innate Immunity Genes During Persistent Islet Autoimmunity Are Associated With Progression of Islet Autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY). Diabetes. 2022 09 01; 71(9):2048-2057. PMID: 35724268.
      View in: PubMed
    16. Sompel K, Dwyer-Nield LD, Smith AJ, Elango AP, Vanderlinden LA, Kopf K, Keith RL, Tennis MA. Loss of Frizzled 9 in Lung Cells Alters Epithelial Phenotype and Promotes Premalignant Lesion Development. Front Oncol. 2022; 12:815737. PMID: 35924166.
      View in: PubMed
    17. Vanderlinden LA, Bemis EA, Seifert J, Guthridge JM, Young KA, Demoruelle MK, Feser M, DeJager W, Macwana S, Mikuls TR, O'Dell JR, Weisman MH, Buckner J, Keating RM, Gaffney PM, Kelly JA, Langefeld CD, Deane KD, James JA, Holers VM, Norris JM. Relationship Between a Vitamin D Genetic Risk Score and Autoantibodies Among First-Degree Relatives of Probands With Rheumatoid Arthritis and Systemic Lupus Erythematosus. Front Immunol. 2022; 13:881332. PMID: 35720397.
      View in: PubMed
    18. Walker-Short E, Buckner T, Vigers T, Carry P, Vanderlinden LA, Dong F, Johnson RK, Yang IV, Kechris K, Rewers M, Norris JM. Epigenome-Wide Association Study of Infant Feeding and DNA Methylation in Infancy and Childhood in a Population at Increased Risk for Type 1 Diabetes. Nutrients. 2021 Nov 13; 13(11). PMID: 34836312.
      View in: PubMed
    19. Vanderlinden LA, Johnson RK, Carry PM, Dong F, DeMeo DL, Yang IV, Norris JM, Kechris K. An effective processing pipeline for harmonizing DNA methylation data from Illumina's 450K and EPIC platforms for epidemiological studies. BMC Res Notes. 2021 Sep 08; 14(1):352. PMID: 34496950.
      View in: PubMed
    20. Vigers T, Vanderlinden LA, Johnson RK, Carry PM, Yang I, DeFelice BC, Kaizer AM, Pyle L, Rewers M, Fiehn O, Norris JM, Kechris K. A Mediation Approach to Discovering Causal Relationships between the Metabolome and DNA Methylation in Type 1 Diabetes. Metabolites. 2021 Aug 14; 11(8). PMID: 34436483.
      View in: PubMed
    21. Carry PM, Terhune EA, Trahan GD, Vanderlinden LA, Wethey CI, Ebrahimi P, McGuigan F, ?kesson K, Hadley-Miller N. Severity of Idiopathic Scoliosis Is Associated with Differential Methylation: An Epigenome-Wide Association Study of Monozygotic Twins with Idiopathic Scoliosis. Genes (Basel). 2021 07 30; 12(8). PMID: 34440365.
      View in: PubMed
    22. Carry PM, Vanderlinden LA, Dong F, Buckner T, Litkowski E, Vigers T, Norris JM, Kechris K. Inverse probability weighting is an effective method to address selection bias during the analysis of high dimensional data. Genet Epidemiol. 2021 09; 45(6):593-603. PMID: 34130352.
      View in: PubMed
    23. Buckner T, Vanderlinden LA, DeFelice BC, Carry PM, Kechris K, Dong F, Fiehn O, Frohnert BI, Clare-Salzler M, Rewers M, Norris JM. The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY). Diabetologia. 2021 08; 64(8):1785-1794. PMID: 33893822.
      View in: PubMed
    24. Carry PM, Vanderlinden LA, Johnson RK, Buckner T, Fiehn O, Steck AK, Kechris K, Yang I, Fingerlin TE, Rewers M, Norris JM. Phospholipid Levels at Seroconversion Are Associated With Resolution of Persistent Islet Autoimmunity: The Diabetes Autoimmunity Study in the Young. Diabetes. 2021 07; 70(7):1592-1601. PMID: 33863802.
      View in: PubMed
    25. Sottnik JL, Vanderlinden L, Joshi M, Chauca-Diaz A, Owens C, Hansel DE, Sempeck C, Ghosh D, Theodorescu D. Androgen Receptor Regulates CD44 Expression in Bladder Cancer. Cancer Res. 2021 06 01; 81(11):2833-2846. PMID: 33687952.
      View in: PubMed
    26. Travers JG, Wennersten SA, Pe?a B, Bagchi RA, Smith HE, Hirsch RA, Vanderlinden LA, Lin YH, Dobrinskikh E, Demos-Davies KM, Cavasin MA, Mestroni L, Steink?hler C, Lin CY, Houser SR, Woulfe KC, Lam MPY, McKinsey TA. HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling. Circulation. 2021 05 11; 143(19):1874-1890. PMID: 33682427.
      View in: PubMed
    27. Earl JB, Vanderlinden LA, Jacobsen TL, Aldrich JC, Saba LM, Britt SG. Identification of Genes Involved in the Differentiation of R7y and R7p Photoreceptor Cells in Drosophila. G3 (Bethesda). 2020 11 05; 10(11):3949-3958. PMID: 32972998.
      View in: PubMed
    28. Johnson RK, Vanderlinden LA, DeFelice BC, Uusitalo U, Seifert J, Fan S, Crume T, Fiehn O, Rewers M, Kechris K, Norris JM. Metabolomics-related nutrient patterns at seroconversion and risk of progression to type 1 diabetes. Pediatr Diabetes. 2020 11; 21(7):1202-1209. PMID: 32686271.
      View in: PubMed
    29. Venter C, Agostoni C, Arshad SH, Ben-Abdallah M, Du Toit G, Fleischer DM, Greenhawt M, Glueck DH, Groetch M, Lunjani N, Maslin K, Maiorella A, Meyer R, Antonella M, Netting MJ, Ibeabughichi Nwaru B, Palmer DJ, Palumbo MP, Roberts G, Roduit C, Smith P, Untersmayr E, Vanderlinden LA, O'Mahony L. Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and Clinical Immunology. Pediatr Allergy Immunol. 2020 11; 31(8):889-912. PMID: 32524677.
      View in: PubMed
    30. Buckner T, Vanderlinden LA, Johnson RK, DeFelice BC, Carry PM, Seifert J, Waugh K, Dong F, Fiehn O, Clare-Salzler M, Rewers M, Norris JM. Predictors of oxylipins in a healthy pediatric population. Pediatr Res. 2021 05; 89(6):1530-1540. PMID: 32726799.
      View in: PubMed
    31. Carry PM, Vanderlinden LA, Johnson RK, Dong F, Steck AK, Frohnert BI, Rewers M, Yang IV, Kechris K, Norris JM. DNA methylation near the INS gene is associated with INS genetic variation (rs689) and type 1 diabetes in the Diabetes Autoimmunity Study in the Young. Pediatr Diabetes. 2020 06; 21(4):597-605. PMID: 32061050.
      View in: PubMed
    32. Johnson RK, Vanderlinden LA, Dong F, Carry PM, Seifert J, Waugh K, Shorrosh H, Fingerlin T, Frohnert BI, Yang IV, Kechris K, Rewers M, Norris JM. Longitudinal DNA methylation differences precede type 1 diabetes. Sci Rep. 2020 02 28; 10(1):3721. PMID: 32111940.
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    33. O'Leary H, Vanderlinden L, Southard L, Castano A, Saba LM, Benke TA. Transcriptome analysis of rat dorsal hippocampal CA1 after an early life seizure induced by kainic acid. Epilepsy Res. 2020 03; 161:106283. PMID: 32062370.
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    34. Johnson RK, Vanderlinden L, DeFelice BC, Kechris K, Uusitalo U, Fiehn O, Sontag M, Crume T, Beyerlein A, Lernmark ?, Toppari J, Ziegler AG, She JX, Hagopian W, Rewers M, Akolkar B, Krischer J, Virtanen SM, Norris JM. Metabolite-related dietary patterns and the development of islet autoimmunity. Sci Rep. 2019 10 15; 9(1):14819. PMID: 31616039.
      View in: PubMed
    35. Wheeler LJ, Watson ZL, Qamar L, Yamamoto TM, Sawyer BT, Sullivan KD, Khanal S, Joshi M, Ferchaud-Roucher V, Smith H, Vanderlinden LA, Brubaker SW, Caino CM, Kim H, Espinosa JM, Richer JK, Bitler BG. Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination. iScience. 2019 Sep 27; 19:474-491. PMID: 31437751.
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    36. Siegrist KJ, Romo D, Upham BL, Armstrong M, Quinn K, Vanderlinden L, Osgood RS, Velmurugan K, Elie M, Manke J, Reinhold D, Reisdorph N, Saba L, Bauer AK. Early Mechanistic Events Induced by Low Molecular Weight Polycyclic Aromatic Hydrocarbons in Mouse Lung Epithelial Cells: A Role for Eicosanoid Signaling. Toxicol Sci. 2019 05 01; 169(1):180-193. PMID: 30690640.
      View in: PubMed
    37. Tabakoff B, Smith H, Vanderlinden LA, Hoffman PL, Saba LM. Networking in Biology: The Hybrid Rat Diversity Panel. Methods Mol Biol. 2019; 2018:213-231. PMID: 31228159.
      View in: PubMed
    38. Lusk R, Saba LM, Vanderlinden LA, Zidek V, Silhavy J, Pravenec M, Hoffman PL, Tabakoff B. Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism. Alcohol Clin Exp Res. 2018 07; 42(7):1177-1191. PMID: 29689131.
      View in: PubMed
    39. Grindler NM, Vanderlinden L, Karthikraj R, Kannan K, Teal S, Polotsky AJ, Powell TL, Yang IV, Jansson T. Exposure to Phthalate, an Endocrine Disrupting Chemical, Alters the First Trimester Placental Methylome and Transcriptome in Women. Sci Rep. 2018 04 17; 8(1):6086. PMID: 29666409.
      View in: PubMed
    40. Baker PR, Patinkin ZW, Shapiro ALB, de la Houssaye BA, Janssen RC, Vanderlinden LA, Dabelea D, Friedman JE. Altered gene expression and metabolism in fetal umbilical cord mesenchymal stem cells correspond with differences in 5-month-old infant adiposity gain. Sci Rep. 2017 12 22; 7(1):18095. PMID: 29273781.
      View in: PubMed
    41. Hoffman PL, Saba LM, Vanderlinden LA, Tabakoff B. Voluntary exposure to a toxin: the genetic influence on ethanol consumption. Mamm Genome. 2018 02; 29(1-2):128-140. PMID: 29196862.
      View in: PubMed
    42. Baker PR, Patinkin Z, Shapiro AL, De La Houssaye BA, Woontner M, Boyle KE, Vanderlinden L, Dabelea D, Friedman JE. Maternal obesity and increased neonatal adiposity correspond with altered infant mesenchymal stem cell metabolism. JCI Insight. 2017 11 02; 2(21). PMID: 29093265.
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    43. Boyle KE, Patinkin ZW, Shapiro ALB, Bader C, Vanderlinden L, Kechris K, Janssen RC, Ford RJ, Smith BK, Steinberg GR, Davidson EJ, Yang IV, Dabelea D, Friedman JE. Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants. Mol Metab. 2017 11; 6(11):1503-1516. PMID: 29107296.
      View in: PubMed
    44. Borghese CM, Herman M, Snell LD, Lawrence KJ, Lee HY, Backos DS, Vanderlinden LA, Harris RA, Roberto M, Hoffman PL, Tabakoff B. Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes. Sci Rep. 2017 07 24; 7(1):6230. PMID: 28740086.
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    45. Duex JE, Owens C, Chauca-Diaz A, Dancik GM, Vanderlinden LA, Ghosh D, Leivo MZ, Hansel DE, Theodorescu D. Nuclear CD24 Drives Tumor Growth and Is Predictive of Poor Patient Prognosis. Cancer Res. 2017 09 15; 77(18):4858-4867. PMID: 28674079.
      View in: PubMed
    46. Tabakoff B, Ren W, Vanderlinden L, Snell LD, Matheson CJ, Wang ZJ, Levinson R, Smothers CT, Woodward JJ, Honse Y, Lovinger D, Rush AM, Sather WA, Gustafson DL, Hoffman PL. A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain. Eur J Pharmacol. 2016 Aug 05; 784:1-14. PMID: 27158117.
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    47. Saba LM, Flink SC, Vanderlinden LA, Israel Y, Tampier L, Colombo G, Kiianmaa K, Bell RL, Printz MP, Flodman P, Koob G, Richardson HN, Lombardo J, Hoffman PL, Tabakoff B. The sequenced rat brain transcriptome--its use in identifying networks predisposing alcohol consumption. FEBS J. 2015 Sep; 282(18):3556-78. PMID: 26183165.
      View in: PubMed
    48. Vanderlinden LA, Saba LM, Bennett B, Hoffman PL, Tabakoff B. Influence of sex on genetic regulation of "drinking in the dark" alcohol consumption. Mamm Genome. 2015 Feb; 26(1-2):43-56. PMID: 25559016.
      View in: PubMed
    49. Zuo L, Lu L, Tan Y, Pan X, Cai Y, Wang X, Hong J, Zhong C, Wang F, Zhang XY, Vanderlinden LA, Tabakoff B, Luo X. Genome-wide association discoveries of alcohol dependence. Am J Addict. 2014 Nov-Dec; 23(6):526-39. PMID: 25278008.
      View in: PubMed
    50. Vanderlinden LA, Saba LM, Printz MP, Flodman P, Koob G, Richardson HN, Hoffman PL, Tabakoff B. Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains. Alcohol Clin Exp Res. 2014 Jul; 38(7):2148-57. PMID: 24961585.
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    51. Vanderlinden LA, Saba LM, Kechris K, Miles MF, Hoffman PL, Tabakoff B. Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption. PLoS One. 2013; 8(7):e68878. PMID: 23894363.
      View in: PubMed
    52. Procopio DO, Saba LM, Walter H, Lesch O, Skala K, Schlaff G, Vanderlinden L, Clapp P, Hoffman PL, Tabakoff B. Genetic markers of comorbid depression and alcoholism in women. Alcohol Clin Exp Res. 2013 Jun; 37(6):896-904. PMID: 23278386.
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    53. O'Brien JH, Vanderlinden LA, Schedin PJ, Hansen KC. Rat mammary extracellular matrix composition and response to ibuprofen treatment during postpartum involution by differential GeLC-MS/MS analysis. J Proteome Res. 2012 Oct 05; 11(10):4894-905. PMID: 22897585.
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    54. McReynolds S, Vanderlinden L, Stevens J, Hansen K, Schoolcraft WB, Katz-Jaffe MG. Lipocalin-1: a potential marker for noninvasive aneuploidy screening. Fertil Steril. 2011 Jun 30; 95(8):2631-3. PMID: 21324447.
      View in: PubMed
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