Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells.
Karimi M, Cao TM, Baker JA, Verneris MR, Soares L, Negrin RS. Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells. J Immunol. 2005 Dec 15; 175(12):7819-28.
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Adaptor Proteins, Signal Transducing
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Animals
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CD8-Positive T-Lymphocytes
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Cell Line, Tumor
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Cytotoxicity, Immunologic
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Female
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Humans
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Immunotherapy, Adoptive
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Killer Cells, Natural
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Male
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Membrane Proteins
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Mice
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Mice, SCID
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Neoplasms, Experimental
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NK Cell Lectin-Like Receptor Subfamily K
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Receptors, Immunologic
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Receptors, Natural Killer Cell
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RNA Interference
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RNA, Small Interfering
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Transduction, Genetic