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Rachel S Friedman

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER

    Collapse Research 
    Collapse research activities and funding
    R21AI178618     (SCOTT-BROWNE, JAMES)Jun 26, 2023 - May 31, 2025
    NIH
    Single Cell Genomics to Resolve Control of Immune Cell Function During Type 1 Diabetes
    Role: Co-Principal Investigator
    R01DK111733     (FRIEDMAN, RACHEL S)Jan 4, 2017 - May 31, 2027
    NIH
    Mertk Mediated T Cell Suppression in the Pancreatic Islets During Type 1 Diabetes
    Role: Principal Investigator
    R21AI119932     (FRIEDMAN, RACHEL S)Jul 1, 2015 - Jun 30, 2018
    NIH
    Role of Formins in Islet Infiltration in Type 1 Diabetes
    Role: Principal Investigator
    R21AI119942     (FRIEDMAN, RACHEL S)Jun 24, 2015 - May 31, 2018
    NIH
    Role of Islet-Infiltrating Lymphocytes in Obesity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Waldman MM, Rahkola JT, Sigler AL, Chung JW, Willett BAS, Kedl RM, Friedman RS, Jacobelli J. Ena/VASP Protein-Mediated Actin Polymerization Contributes to Na?ve CD8+ T Cell Activation and Expansion by Promoting T Cell-APC Interactions In Vivo. Front Immunol. 2022; 13:856977. PMID: 35757762.
      View in: PubMed
    2. Ravenna PA, Wheat S, El Rayess F, McCrea L, Martonffy AI, Marshall C, Tepperberg S, Friedman RSC, Barr WB. Diversity, Equity, and Inclusion Milestones: Creation of a Tool to Evaluate Graduate Medical Education Programs. J Grad Med Educ. 2022 Apr; 14(2):166-170. PMID: 35463173.
      View in: PubMed
    3. Friedman RSC, Carpenter DM, Shaver JM, McDermott SC, Voelkel J. Telemedicine Familiarity and Post-Disaster Utilization of Emergency and Hospital Services for Ambulatory Care Sensitive Conditions. Am J Prev Med. 2022 07; 63(1):e1-e9. PMID: 35300889.
      View in: PubMed
    4. Whitesell JC, Lindsay RS, Olivas-Corral JG, Yannacone SF, Schoenbach MH, Lucas ED, Friedman RS. Islet Lymphocytes Maintain a Stable Regulatory Phenotype Under Homeostatic Conditions and Metabolic Stress. Front Immunol. 2022; 13:814203. PMID: 35145521.
      View in: PubMed
    5. Felipe-Lucia MR, Guerrero AM, Alexander SM, Ashander J, Baggio JA, Barnes ML, Bodin ?, Bonn A, Fortin MJ, Friedman RS, Gephart JA, Helmstedt KJ, Keyes AA, Kroetz K, Massol F, Pocock MJO, Sayles J, Thompson RM, Wood SA, Dee LE. Conceptualizing ecosystem services using social-ecological networks. Trends Ecol Evol. 2022 03; 37(3):211-222. PMID: 34969536.
      View in: PubMed
    6. Jacobelli J, Buser AE, Heiden DL, Friedman RS. Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging. Immunol Rev. 2022 03; 306(1):181-199. PMID: 34825390.
      View in: PubMed
    7. Lindsay RS, Whitesell JC, Dew KE, Rodriguez E, Sandor AM, Tracy D, Yannacone SF, Basta BN, Jacobelli J, Friedman RS. MERTK on mononuclear phagocytes regulates T cell antigen recognition at autoimmune and tumor sites. J Exp Med. 2021 10 04; 218(10). PMID: 34415994.
      View in: PubMed
    8. Summers ME, Richmond BW, Menon S, Sheridan RM, Kropski JA, Majka SA, Taketo MM, Bastarache JA, West JD, De Langhe S, Geraghty P, Klemm DJ, Chu HW, Friedman RS, Tao YK, Foronjy RF, Majka SM. Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling. FASEB J. 2020 08; 34(8):10267-10285. PMID: 32533805.
      View in: PubMed
    9. Thompson SB, Sandor AM, Lui V, Chung JW, Waldman MM, Long RA, Estin ML, Matsuda JL, Friedman RS, Jacobelli J. Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity. Elife. 2020 06 08; 9. PMID: 32510333.
      View in: PubMed
    10. Sandor AM, Jacobelli J, Friedman RS. Immune cell trafficking to the islets during type 1 diabetes. Clin Exp Immunol. 2019 12; 198(3):314-325. PMID: 31343073.
      View in: PubMed
    11. Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS. CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes. Front Immunol. 2019; 10:99. PMID: 30766536.
      View in: PubMed
    12. Baker RL, Jamison BL, Wiles TA, Lindsay RS, Barbour G, Bradley B, Delong T, Friedman RS, Nakayama M, Haskins K. CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse. Diabetes. 2018 09; 67(9):1836-1846. PMID: 29976617.
      View in: PubMed
    13. Dell'Aringa M, Reinhardt RL, Friedman RS, Jacobelli J. Live Imaging of IL-4-Expressing T Follicular Helper Cells in Explanted Lymph Nodes. Methods Mol Biol. 2018; 1799:225-235. PMID: 29956155.
      View in: PubMed
    14. Kedl RM, Lindsay RS, Finlon JM, Lucas ED, Friedman RS, Tamburini BAJ. Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction. Nat Commun. 2017 12 11; 8(1):2034. PMID: 29229919.
      View in: PubMed
    15. Eshleman EM, Delgado C, Kearney SJ, Friedman RS, Lenz LL. Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection. PLoS Pathog. 2017 May; 13(5):e1006388. PMID: 28542482.
      View in: PubMed
    16. Estin ML, Thompson SB, Traxinger B, Fisher MH, Friedman RS, Jacobelli J. Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2901-E2910. PMID: 28320969.
      View in: PubMed
    17. Packard TA, Smith MJ, Conrad FJ, Johnson SA, Getahun A, Lindsay RS, Hinman RM, Friedman RS, Thomas JW, Cambier JC. B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes. J Clin Med. 2016 Nov 08; 5(11). PMID: 27834793.
      View in: PubMed
    18. Baker RL, Bradley B, Wiles TA, Lindsay RS, Barbour G, Delong T, Friedman RS, Haskins K. Cutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes. J Immunol. 2016 Jan 01; 196(1):39-43. PMID: 26608914.
      View in: PubMed
    19. Rubtsov AV, Rubtsova K, Kappler JW, Jacobelli J, Friedman RS, Marrack P. CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs. J Immunol. 2015 Jul 01; 195(1):71-9. PMID: 26034175.
      View in: PubMed
    20. Lindsay RS, Corbin K, Mahne A, Levitt BE, Gebert MJ, Wigton EJ, Bradley BJ, Haskins K, Jacobelli J, Tang Q, Krummel MF, Friedman RS. Antigen recognition in the islets changes with progression of autoimmune islet infiltration. J Immunol. 2015 Jan 15; 194(2):522-30. PMID: 25505281.
      View in: PubMed
    21. Friedman RS, Lindsay RS, Lilly JK, Nguyen V, Sorensen CM, Jacobelli J, Krummel MF. An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9223-8. PMID: 24927530.
      View in: PubMed
    22. Krummel MF, Friedman RS, Jacobelli J. Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA. Curr Opin Cell Biol. 2014 Oct; 30:9-16. PMID: 24905977.
      View in: PubMed
    23. Jacobelli J, Lindsay RS, Friedman RS. Peripheral tolerance and autoimmunity: lessons from in vivo imaging. Immunol Res. 2013 Mar; 55(1-3):146-54. PMID: 22956468.
      View in: PubMed
    24. McKee AS, Burchill MA, Munks MW, Jin L, Kappler JW, Friedman RS, Jacobelli J, Marrack P. Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):E1122-31. PMID: 23447566.
      View in: PubMed
    25. G?rard A, Beemiller P, Friedman RS, Jacobelli J, Krummel MF. Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses. Immunol Rev. 2013 Jan; 251(1):80-96. PMID: 23278742.
      View in: PubMed
    26. Friedman RS, Beemiller P, Sorensen CM, Jacobelli J, Krummel MF. Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. J Exp Med. 2010 Nov 22; 207(12):2733-49. PMID: 21041455.
      View in: PubMed
    27. Katzman SD, O'Gorman WE, Villarino AV, Gallo E, Friedman RS, Krummel MF, Nolan GP, Abbas AK. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18085-90. PMID: 20921406.
      View in: PubMed
    28. Friedman RS, Burg MM, Miles P, Lee F, Lampert R. Effects of Reiki on autonomic activity early after acute coronary syndrome. J Am Coll Cardiol. 2010 Sep 14; 56(12):995-6. PMID: 20828654.
      View in: PubMed
    29. Jacobelli J, Friedman RS, Conti MA, Lennon-Dumenil AM, Piel M, Sorensen CM, Adelstein RS, Krummel MF. Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol. 2010 Oct; 11(10):953-61. PMID: 20835229.
      View in: PubMed
    30. Friedman RS, Krause DS. Regeneration and repair: new findings in stem cell research and aging. Ann N Y Acad Sci. 2009 Aug; 1172:88-94. PMID: 19735242.
      View in: PubMed
    31. Melli K, Friedman RS, Martin AE, Finger EB, Miao G, Szot GL, Krummel MF, Tang Q. Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues. J Immunol. 2009 Mar 01; 182(5):2590-600. PMID: 19234153.
      View in: PubMed
    32. Bullen A, Friedman RS, Krummel MF. Two-photon imaging of the immune system: a custom technology platform for high-speed, multicolor tissue imaging of immune responses. Curr Top Microbiol Immunol. 2009; 334:1-29. PMID: 19521679.
      View in: PubMed
    33. Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008 Aug 08; 321(5890):843-7. PMID: 18687966.
      View in: PubMed
    34. Sabatos CA, Doh J, Chakravarti S, Friedman RS, Pandurangi PG, Tooley AJ, Krummel MF. A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction. Immunity. 2008 Aug 15; 29(2):238-48. PMID: 18674934.
      View in: PubMed
    35. Friedman RS, Jacobelli J, Krummel MF. Surface-bound chemokines capture and prime T cells for synapse formation. Nat Immunol. 2006 Oct; 7(10):1101-8. PMID: 16964261.
      View in: PubMed
    36. Friedman RS, Jacobelli J, Krummel MF. Mechanisms of T cell motility and arrest: deciphering the relationship between intra- and extracellular determinants. Semin Immunol. 2005 Dec; 17(6):387-99. PMID: 16219473.
      View in: PubMed
    37. Friedman RS, Spies AG, Kalos M. Identification of naturally processed CD8 T cell epitopes from prostein, a prostate tissue-specific vaccine candidate. Eur J Immunol. 2004 Apr; 34(4):1091-101. PMID: 15048720.
      View in: PubMed
    38. Friedman RS, Bangur CS, Zasloff EJ, Fan L, Wang T, Watanabe Y, Kalos M. Molecular and immunological evaluation of the transcription factor SOX-4 as a lung tumor vaccine antigen. J Immunol. 2004 Mar 01; 172(5):3319-27. PMID: 14978140.
      View in: PubMed
    39. Hural JA, Friedman RS, McNabb A, Steen SS, Henderson RA, Kalos M. Identification of naturally processed CD4 T cell epitopes from the prostate-specific antigen kallikrein 4 using peptide-based in vitro stimulation. J Immunol. 2002 Jul 01; 169(1):557-65. PMID: 12077288.
      View in: PubMed
    40. Friedman RS, Frankel FR, Xu Z, Lieberman J. Induction of human immunodeficiency virus (HIV)-specific CD8 T-cell responses by Listeria monocytogenes and a hyperattenuated Listeria strain engineered to express HIV antigens. J Virol. 2000 Nov; 74(21):9987-93. PMID: 11024127.
      View in: PubMed
    41. Beresford PJ, Jaju M, Friedman RS, Yoon MJ, Lieberman J. A role for heat shock protein 27 in CTL-mediated cell death. J Immunol. 1998 Jul 01; 161(1):161-7. PMID: 9647220.
      View in: PubMed
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