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Liliya Vugmeyster

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Denver Campus

    Collapse Research 
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    R15GM111681     (VUGMEYSTER, LILIYA)Aug 1, 2014 - Apr 30, 2021
    Dynamics of Disordered Regions of Amyloid Fibrils
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Vögeli B, Vugmeyster L. Distance-independent Cross-correlated Relaxation and Isotropic Chemical Shift Modulation in Protein Dynamics Studies. Chemphyschem. 2019 Jan 21; 20(2):178-196. PMID: 30110510.
      View in: PubMed
    2. Vugmeyster L, Ostrovsky D. Deuterium Rotating Frame NMR Relaxation Measurements in the Solid State under Static Conditions for Quantification of Dynamics. Chemphyschem. 2019 Jan 21; 20(2):333-342. PMID: 30079456.
      View in: PubMed
    3. Vugmeyster L, Griffin A, Ostrovsky D, Bhattacharya S, Nichols PJ, McKnight CJ, Vögeli B. Correlated motions of C'-N and Ca-Cß pairs in protonated and per-deuterated GB3. J Biomol NMR. 2018 Oct; 72(1-2):39-54. PMID: 30121872.
      View in: PubMed
    4. Vugmeyster L, Ostrovsky D. Basic experiments in 2H static NMR for the characterization of protein side-chain dynamics. Methods. 2018 Sep 15; 148:136-145. PMID: 29705208.
      View in: PubMed
    5. Miears HL, Gruber DR, Horvath NM, Antos JM, Young J, Sigurjonsson JP, Klem ML, Rosenkranz EA, Okon M, McKnight CJ, Vugmeyster L, Smirnov SL. Plant Villin Headpiece Domain Demonstrates a Novel Surface Charge Pattern and High Affinity for F-Actin. Biochemistry. 2018 03 20; 57(11):1690-1701. PMID: 29444403.
      View in: PubMed
    6. Falconer IB, Mant CT, McKnight CJ, Vugmeyster L, Hodges R. Optimized purification of a fusion protein by reversed-phase high performance liquid chromatography informed by the linear solvent strength model. J Chromatogr A. 2017 Oct 27; 1521:44-52. PMID: 28942999.
      View in: PubMed
    7. Vugmeyster L, Ostrovsky D, Hoatson GL, Qiang W, Falconer IB. Solvent-Driven Dynamical Crossover in the Phenylalanine Side-Chain from the Hydrophobic Core of Amyloid Fibrils Detected by 2H NMR Relaxation. J Phys Chem B. 2017 08 03; 121(30):7267-7275. PMID: 28699757.
      View in: PubMed
    8. Vugmeyster L, Ostrovsky D. Static solid-state 2H NMR methods in studies of protein side-chain dynamics. Prog Nucl Magn Reson Spectrosc. 2017 08; 101:1-17. PMID: 28844219.
      View in: PubMed
    9. Vugmeyster L, Ostrovsky D. Comparative Dynamics of Methionine Side-Chain in FMOC-Methionine and in Amyloid Fibrils. Chem Phys Lett. 2017 Apr; 673:108-112. PMID: 28959059.
      View in: PubMed
    10. Vugmeyster L, Ostrovsky D, Clark MA, Falconer IB, Hoatson GL, Qiang W. Fast Motions of Key Methyl Groups in Amyloid-ß Fibrils. Biophys J. 2016 Nov 15; 111(10):2135-2148. PMID: 27851938.
      View in: PubMed
    11. Vugmeyster L, Clark MA, Falconer IB, Ostrovsky D, Gantz D, Qiang W, Hoatson GL. Flexibility and Solvation of Amyloid-ß Hydrophobic Core. J Biol Chem. 2016 08 26; 291(35):18484-95. PMID: 27402826; PMCID: PMC5000093 [Available on 08/26/17].
    12. Vugmeyster L, Ostrovsky D, Villafranca T, Sharp J, Xu W, Lipton AS, Hoatson GL, Vold RL. Dynamics of Hydrophobic Core Phenylalanine Residues Probed by Solid-State Deuteron NMR. J Phys Chem B. 2015 Nov 25; 119(47):14892-904. PMID: 26529128; PMCID: PMC4970646 [Available on 11/25/16].
    13. Harpole KW, O'Brien ES, Clark MA, McKnight CJ, Vugmeyster L, Wand AJ. The unusual internal motion of the villin headpiece subdomain. Protein Sci. 2016 Feb; 25(2):423-32. PMID: 26473993; PMCID: PMC4815346 [Available on 02/01/17].
    14. Vugmeyster L, Ostrovsky D, Fu R. (15)N CSA tensors and (15)N-(1)H dipolar couplings of protein hydrophobic core residues investigated by static solid-state NMR. J Magn Reson. 2015 Oct; 259:225-31. PMID: 26367322; PMCID: PMC4600402 [Available on 10/01/16].
    15. Vugmeyster L, Ostrovsky D. Restricted diffusion of methyl groups in proteins revealed by deuteron NMR: manifestation of intra-well dynamics. J Chem Phys. 2014 Feb 21; 140(7):075101. PMID: 24559369.
      View in: PubMed
    16. Vugmeyster L, Do T, Ostrovsky D, Fu R. Effect of subdomain interactions on methyl group dynamics in the hydrophobic core of villin headpiece protein. Protein Sci. 2014 Feb; 23(2):145-56. PMID: 24243806; PMCID: PMC3926740.
    17. Vugmeyster L, Ostrovsky D, Lipton AS. Origin of abrupt rise in deuteron NMR longitudinal relaxation times of protein methyl groups below 90 K. J Phys Chem B. 2013 May 23; 117(20):6129-37. PMID: 23627365.
      View in: PubMed
    18. Vugmeyster L, Ostrovsky D, Penland K, Hoatson GL, Vold RL. Glassy dynamics of protein methyl groups revealed by deuteron NMR. J Phys Chem B. 2013 Jan 31; 117(4):1051-61. PMID: 23301823; PMCID: PMC3607545.
    19. Vugmeyster L, Do T, Ostrovsky D, Fu R, Hagedorn B. Characterization of water dynamics in frozen soils by solid-state deuteron NMR. Solid State Nucl Magn Reson. 2012 Jul-Sep; 45-46:11-5. PMID: 22578873.
      View in: PubMed
    20. Vugmeyster L, Ostrovsky D, Khadjinova A, Ellden J, Hoatson GL, Vold RL. Slow motions in the hydrophobic core of chicken villin headpiece subdomain and their contributions to configurational entropy and heat capacity from solid-state deuteron NMR measurements. Biochemistry. 2011 Dec 13; 50(49):10637-46. PMID: 22085262; PMCID: PMC3366553.
    21. Vugmeyster L, Ostrovsky D. Temperature dependence of fast carbonyl backbone dynamics in chicken villin headpiece subdomain. J Biomol NMR. 2011 Jun; 50(2):119-27. PMID: 21416162; PMCID: PMC3366550.
    22. Vugmeyster L, Ostrovsky D, Moses M, Ford JJ, Lipton AS, Hoatson GL, Vold RL. Comparative dynamics of leucine methyl groups in FMOC-leucine and in a protein hydrophobic core probed by solid-state deuteron nuclear magnetic resonance over 7-324 K temperature range. J Phys Chem B. 2010 Dec 09; 114(48):15799-807. PMID: 21077644.
      View in: PubMed
    23. Vugmeyster L, Ostrovsky D, Li Y. Comparison of fast backbone dynamics at amide nitrogen and carbonyl sites in dematin headpiece C-terminal domain and its S74E mutant. J Biomol NMR. 2010 Jun; 47(2):155-62. PMID: 20396930.
      View in: PubMed
    24. Vugmeyster L, Ostrovsky D, Ford JJ, Lipton AS. Freezing of dynamics of a methyl group in a protein hydrophobic core at cryogenic temperatures by deuteron NMR spectroscopy. J Am Chem Soc. 2010 Mar 31; 132(12):4038-9. PMID: 20201523.
      View in: PubMed
    25. Vugmeyster L, Ostrovsky D, Ford JJ, Burton SD, Lipton AS, Hoatson GL, Vold RL. Probing the dynamics of a protein hydrophobic core by deuteron solid-state nuclear magnetic resonance spectroscopy. J Am Chem Soc. 2009 Sep 30; 131(38):13651-8. PMID: 19772361.
      View in: PubMed
    26. Vugmeyster L. Slow backbone dynamics of chicken villin headpiece subdomain probed by NMR C'-N cross-correlated relaxation. Magn Reson Chem. 2009 Sep; 47(9):746-51. PMID: 19479944.
      View in: PubMed
    27. Vold RL, Hoatson GL, Vugmeyster L, Ostrovsky D, De Castro PJ. Solid state deuteron relaxation time anisotropy measured with multiple echo acquisition. Phys Chem Chem Phys. 2009 Aug 28; 11(32):7008-12. PMID: 19652835.
      View in: PubMed
    28. Vugmeyster L, McKnight CJ. Phosphorylation-induced changes in backbone dynamics of the dematin headpiece C-terminal domain. J Biomol NMR. 2009 Jan; 43(1):39-50. PMID: 19030997; PMCID: PMC2796552.
    29. Vugmeyster L, McKnight CJ. Slow motions in chicken villin headpiece subdomain probed by cross-correlated NMR relaxation of amide NH bonds in successive residues. Biophys J. 2008 Dec 15; 95(12):5941-50. PMID: 18820237; PMCID: PMC2599813.
    30. Vugmeyster L, Perazzolo C, Wist J, Frueh D, Bodenhausen G. Evidence of slow motions by cross-correlated chemical shift modulation in deuterated and protonated proteins. J Biomol NMR. 2004 Feb; 28(2):173-7. PMID: 14755161.
      View in: PubMed
    31. Vugmeyster L, Raleigh DP, Palmer AG, Vugmeister BE. Beyond the decoupling approximation in the model free approach for the interpretation of NMR relaxation of macromolecules in solution. J Am Chem Soc. 2003 Jul 09; 125(27):8400-4. PMID: 12837113.
      View in: PubMed
    32. Wang M, Tang Y, Sato S, Vugmeyster L, McKnight CJ, Raleigh DP. Dynamic NMR line-shape analysis demonstrates that the villin headpiece subdomain folds on the microsecond time scale. J Am Chem Soc. 2003 May 21; 125(20):6032-3. PMID: 12785814.
      View in: PubMed
    33. Vugmeyster L, Trott O, McKnight CJ, Raleigh DP, Palmer AG. Temperature-dependent dynamics of the villin headpiece helical subdomain, an unusually small thermostable protein. J Mol Biol. 2002 Jul 19; 320(4):841-54. PMID: 12095260.
      View in: PubMed
    34. Vugmeyster L, Kuhlman B, Raleigh DP. Amide proton exchange measurements as a probe of the stability and dynamics of the N-terminal domain of the ribosomal protein L9: comparison with the intact protein. Protein Sci. 1998 Sep; 7(9):1994-7. PMID: 9761480; PMCID: PMC2144167.
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