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Liliya Vugmeyster

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Denver Campus
DepartmentCLAS-Chemistry
Phone303/315-7653

    Collapse Research 
    Collapse research activities and funding
    R15GM111681     (VUGMEYSTER, LILIYA)Aug 1, 2014 - Aug 31, 2024
    NIH
    Variant-specific dynamics of amyloid-b fibrils
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Vugmeyster L, Au DF, Frazier B, Qiang W, Ostrovsky D. Rigidifying of the internal dynamics of amyloid-beta fibrils generated in the presence of synaptic plasma vesicles. Phys Chem Chem Phys. 2024 Feb 07; 26(6):5466-5478. PMID: 38277177.
      View in: PubMed
    2. Vugmeyster L, Ostrovsky D, Rodgers A, Gwin K, Smirnov SL, McKnight CJ, Fu R. Persistence of Methionine Side Chain Mobility at Low Temperatures in a Nine-Residue Low Complexity Peptide, as Probed by 2 H Solid-State NMR. Chemphyschem. 2024 Feb 16; 25(4):e202300565. PMID: 38175858.
      View in: PubMed
    3. Cruceta L, Sun Y, Kenyaga JM, Ostrovsky D, Rodgers A, Vugmeyster L, Yao L, Qiang W. Modulation of aggregation and structural polymorphisms of ?-amyloid fibrils in cellular environments by pyroglutamate-3 variant cross-seeding. J Biol Chem. 2023 Oct; 299(10):105196. PMID: 37633335.
      View in: PubMed
    4. Vugmeyster L, Rodgers A, Gwin K, Ostrovsky D, Smirnov SL. Nine-residue low-complexity disordered peptide as a model system, an NMR/CD study. bioRxiv. 2023 Jun 27. PMID: 36824859.
      View in: PubMed
    5. Vugmeyster L, Rodgers A, Ostrovsky D, James McKnight C, Fu R. Deuteron off-resonance rotating frame relaxation for the characterization of slow motions in rotating and static solid-state proteins. J Magn Reson. 2023 07; 352:107493. PMID: 37271094.
      View in: PubMed
    6. Rodgers A, Sawaged M, Ostrovsky D, Vugmeyster L. Effect of Cross-Seeding of Wild-Type Amyloid-?1-40 Peptides with Post-translationally Modified Fibrils on Internal Dynamics of the Fibrils Using Deuterium Solid-State NMR. J Phys Chem B. 2023 04 06; 127(13):2887-2899. PMID: 36952330.
      View in: PubMed
    7. Vugmeyster L, Nichols PJ, Ostrovsky D, McKnight CJ, V?geli B. Slow methyl axes motions in perdeuterated villin headpiece subdomain probed by cross-correlated NMR relaxation measurements. Magnetochemistry. 2023 Jan; 9(1). PMID: 36776538.
      View in: PubMed
    8. Vugmeyster L, Ostrovsky D, Greenwood A, Fu R. Deuteron rotating frame relaxation for the detection of slow motions in rotating solids. J Magn Reson. 2022 04; 337:107171. PMID: 35219160.
      View in: PubMed
    9. Vugmeyster L, Fai Au D, Smith MC, Ostrovsky D. Comparative Hydrophobic Core Dynamics Between Wild-Type Amyloid-? Fibrils, Glutamate-3 Truncation, and Serine-8 Phosphorylation. Chemphyschem. 2022 02 04; 23(3):e202100709. PMID: 34837296.
      View in: PubMed
    10. Vugmeyster L, Ostrovsky D, Greenwood A, Fu R. Deuteron Chemical Exchange Saturation Transfer for the Detection of Slow Motions in Rotating Solids. Front Mol Biosci. 2021; 8:705572. PMID: 34386521.
      View in: PubMed
    11. Vugmeyster L. Recent developments in deuterium solid-state NMR for the detection of slow motions in proteins. Solid State Nucl Magn Reson. 2021 02; 111:101710. PMID: 33450712.
      View in: PubMed
    12. Vugmeyster L, Ostrovsky D. Deuterium solid-state NMR quadrupolar order rotating frame relaxation with applications to amyloid-? fibrils. Magn Reson Chem. 2021 Sep; 59(9-10):853-863. PMID: 33161607.
      View in: PubMed
    13. Hu ZW, Au DF, Cruceta L, Vugmeyster L, Qiang W. N-Terminal Modified A? Variants Enable Modulations to the Structures and Cytotoxicity Levels of Wild-Type A? Fibrils through Cross-Seeding. ACS Chem Neurosci. 2020 07 15; 11(14):2058-2065. PMID: 32603584.
      View in: PubMed
    14. Vugmeyster L, Au DF, Ostrovsky D, Rickertsen DRL, Reed SM. Dynamics of Serine-8 Side-Chain in Amyloid-? Fibrils and Fluorenylmethyloxycarbonyl Serine Amino Acid, Investigated by Solid-State Deuteron NMR. J Phys Chem B. 2020 06 11; 124(23):4723-4731. PMID: 32396356.
      View in: PubMed
    15. Nichols PJ, Falconer I, Griffin A, Mant C, Hodges R, McKnight CJ, V?geli B, Vugmeyster L. Deuteration of nonexchangeable protons on proteins affects their thermal stability, side-chain dynamics, and hydrophobicity. Protein Sci. 2020 07; 29(7):1641-1654. PMID: 32356390.
      View in: PubMed
    16. Vugmeyster L, Ostrovsky D, Fu R. Deuteron Quadrupolar Chemical Exchange Saturation Transfer (Q-CEST) Solid-State NMR for Static Powder Samples: Approach and Applications to Amyloid-? Fibrils. Chemphyschem. 2020 02 04; 21(3):220-231. PMID: 31805217.
      View in: PubMed
    17. Vugmeyster L, Au DF, Ostrovsky D, Kierl B, Fu R, Hu ZW, Qiang W. Effect of Post-Translational Modifications and Mutations on Amyloid-? Fibrils Dynamics at N?Terminus. Biophys J. 2019 10 15; 117(8):1524-1535. PMID: 31570231.
      View in: PubMed
    18. Vugmeyster L, Au DF, Ostrovsky D, Fu R. Deuteron Solid-State NMR Relaxation Measurements Reveal Two Distinct Conformational Exchange Processes in the Disordered N-Terminal Domain of Amyloid-? Fibrils. Chemphyschem. 2019 07 02; 20(13):1680-1689. PMID: 31087613.
      View in: PubMed
    19. Hu ZW, Vugmeyster L, Au DF, Ostrovsky D, Sun Y, Qiang W. Molecular structure of an N-terminal phosphorylated ?-amyloid fibril. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11253-11258. PMID: 31097588.
      View in: PubMed
    20. Au DF, Ostrovsky D, Fu R, Vugmeyster L. Solid-state NMR reveals a comprehensive view of the dynamics of the flexible, disordered N-terminal domain of amyloid-? fibrils. J Biol Chem. 2019 04 12; 294(15):5840-5853. PMID: 30737281.
      View in: PubMed
    21. V?geli B, Vugmeyster L. Distance-independent Cross-correlated Relaxation and Isotropic Chemical Shift Modulation in Protein Dynamics Studies. Chemphyschem. 2019 01 21; 20(2):178-196. PMID: 30110510.
      View in: PubMed
    22. Vugmeyster L, Ostrovsky D. Deuterium Rotating Frame NMR Relaxation Measurements in the Solid State under Static Conditions for Quantification of Dynamics. Chemphyschem. 2019 01 21; 20(2):333-342. PMID: 30079456.
      View in: PubMed
    23. Vugmeyster L, Griffin A, Ostrovsky D, Bhattacharya S, Nichols PJ, McKnight CJ, V?geli B. Correlated motions of C'-N and Ca-C? pairs in protonated and per-deuterated GB3. J Biomol NMR. 2018 Oct; 72(1-2):39-54. PMID: 30121872.
      View in: PubMed
    24. Vugmeyster L, Ostrovsky D. Basic experiments in 2H static NMR for the characterization of protein side-chain dynamics. Methods. 2018 09 15; 148:136-145. PMID: 29705208.
      View in: PubMed
    25. Miears HL, Gruber DR, Horvath NM, Antos JM, Young J, Sigurjonsson JP, Klem ML, Rosenkranz EA, Okon M, McKnight CJ, Vugmeyster L, Smirnov SL. Plant Villin Headpiece Domain Demonstrates a Novel Surface Charge Pattern and High Affinity for F-Actin. Biochemistry. 2018 03 20; 57(11):1690-1701. PMID: 29444403.
      View in: PubMed
    26. Falconer IB, Mant CT, McKnight CJ, Vugmeyster L, Hodges R. Optimized purification of a fusion protein by reversed-phase high performance liquid chromatography informed by the linear solvent strength model. J Chromatogr A. 2017 Oct 27; 1521:44-52. PMID: 28942999.
      View in: PubMed
    27. Vugmeyster L, Ostrovsky D, Hoatson GL, Qiang W, Falconer IB. Solvent-Driven Dynamical Crossover in the Phenylalanine Side-Chain from the Hydrophobic Core of Amyloid Fibrils Detected by 2H NMR Relaxation. J Phys Chem B. 2017 08 03; 121(30):7267-7275. PMID: 28699757.
      View in: PubMed
    28. Vugmeyster L, Ostrovsky D. Static solid-state 2H NMR methods in studies of protein side-chain dynamics. Prog Nucl Magn Reson Spectrosc. 2017 08; 101:1-17. PMID: 28844219.
      View in: PubMed
    29. Vugmeyster L, Ostrovsky D. Comparative Dynamics of Methionine Side-Chain in FMOC-Methionine and in Amyloid Fibrils. Chem Phys Lett. 2017 Apr; 673:108-112. PMID: 28959059.
      View in: PubMed
    30. Vugmeyster L, Ostrovsky D, Clark MA, Falconer IB, Hoatson GL, Qiang W. Fast Motions of Key Methyl Groups in Amyloid-? Fibrils. Biophys J. 2016 Nov 15; 111(10):2135-2148. PMID: 27851938.
      View in: PubMed
    31. Vugmeyster L, Clark MA, Falconer IB, Ostrovsky D, Gantz D, Qiang W, Hoatson GL. Flexibility and Solvation of Amyloid-? Hydrophobic Core. J Biol Chem. 2016 08 26; 291(35):18484-95. PMID: 27402826.
      View in: PubMed
    32. Vugmeyster L, Ostrovsky D, Villafranca T, Sharp J, Xu W, Lipton AS, Hoatson GL, Vold RL. Dynamics of Hydrophobic Core Phenylalanine Residues Probed by Solid-State Deuteron NMR. J Phys Chem B. 2015 Nov 25; 119(47):14892-904. PMID: 26529128.
      View in: PubMed
    33. Harpole KW, O'Brien ES, Clark MA, McKnight CJ, Vugmeyster L, Wand AJ. The unusual internal motion of the villin headpiece subdomain. Protein Sci. 2016 Feb; 25(2):423-32. PMID: 26473993.
      View in: PubMed
    34. Vugmeyster L, Ostrovsky D, Fu R. (15)N CSA tensors and (15)N-(1)H dipolar couplings of protein hydrophobic core residues investigated by static solid-state NMR. J Magn Reson. 2015 Oct; 259:225-31. PMID: 26367322.
      View in: PubMed
    35. Vugmeyster L, Ostrovsky D. Restricted diffusion of methyl groups in proteins revealed by deuteron NMR: manifestation of intra-well dynamics. J Chem Phys. 2014 Feb 21; 140(7):075101. PMID: 24559369.
      View in: PubMed
    36. Vugmeyster L, Do T, Ostrovsky D, Fu R. Effect of subdomain interactions on methyl group dynamics in the hydrophobic core of villin headpiece protein. Protein Sci. 2014 Feb; 23(2):145-56. PMID: 24243806.
      View in: PubMed
    37. Vugmeyster L, Ostrovsky D, Lipton AS. Origin of abrupt rise in deuteron NMR longitudinal relaxation times of protein methyl groups below 90 K. J Phys Chem B. 2013 May 23; 117(20):6129-37. PMID: 23627365.
      View in: PubMed
    38. Vugmeyster L, Ostrovsky D, Penland K, Hoatson GL, Vold RL. Glassy dynamics of protein methyl groups revealed by deuteron NMR. J Phys Chem B. 2013 Jan 31; 117(4):1051-61. PMID: 23301823.
      View in: PubMed
    39. Vugmeyster L, Do T, Ostrovsky D, Fu R, Hagedorn B. Characterization of water dynamics in frozen soils by solid-state deuteron NMR. Solid State Nucl Magn Reson. 2012 Jul-Sep; 45-46:11-5. PMID: 22578873.
      View in: PubMed
    40. Vugmeyster L, Ostrovsky D, Khadjinova A, Ellden J, Hoatson GL, Vold RL. Slow motions in the hydrophobic core of chicken villin headpiece subdomain and their contributions to configurational entropy and heat capacity from solid-state deuteron NMR measurements. Biochemistry. 2011 Dec 13; 50(49):10637-46. PMID: 22085262.
      View in: PubMed
    41. Vugmeyster L, Ostrovsky D. Temperature dependence of fast carbonyl backbone dynamics in chicken villin headpiece subdomain. J Biomol NMR. 2011 Jun; 50(2):119-27. PMID: 21416162.
      View in: PubMed
    42. Vugmeyster L, Ostrovsky D, Moses M, Ford JJ, Lipton AS, Hoatson GL, Vold RL. Comparative dynamics of leucine methyl groups in FMOC-leucine and in a protein hydrophobic core probed by solid-state deuteron nuclear magnetic resonance over 7-324 K temperature range. J Phys Chem B. 2010 Dec 09; 114(48):15799-807. PMID: 21077644.
      View in: PubMed
    43. Vugmeyster L, Ostrovsky D, Li Y. Comparison of fast backbone dynamics at amide nitrogen and carbonyl sites in dematin headpiece C-terminal domain and its S74E mutant. J Biomol NMR. 2010 Jun; 47(2):155-62. PMID: 20396930.
      View in: PubMed
    44. Vugmeyster L, Ostrovsky D, Ford JJ, Lipton AS. Freezing of dynamics of a methyl group in a protein hydrophobic core at cryogenic temperatures by deuteron NMR spectroscopy. J Am Chem Soc. 2010 Mar 31; 132(12):4038-9. PMID: 20201523.
      View in: PubMed
    45. Vugmeyster L, Ostrovsky D, Ford JJ, Burton SD, Lipton AS, Hoatson GL, Vold RL. Probing the dynamics of a protein hydrophobic core by deuteron solid-state nuclear magnetic resonance spectroscopy. J Am Chem Soc. 2009 Sep 30; 131(38):13651-8. PMID: 19772361.
      View in: PubMed
    46. Vugmeyster L. Slow backbone dynamics of chicken villin headpiece subdomain probed by NMR C'-N cross-correlated relaxation. Magn Reson Chem. 2009 Sep; 47(9):746-51. PMID: 19479944.
      View in: PubMed
    47. Vold RL, Hoatson GL, Vugmeyster L, Ostrovsky D, De Castro PJ. Solid state deuteron relaxation time anisotropy measured with multiple echo acquisition. Phys Chem Chem Phys. 2009 Aug 28; 11(32):7008-12. PMID: 19652835.
      View in: PubMed
    48. Vugmeyster L, McKnight CJ. Phosphorylation-induced changes in backbone dynamics of the dematin headpiece C-terminal domain. J Biomol NMR. 2009 Jan; 43(1):39-50. PMID: 19030997.
      View in: PubMed
    49. Vugmeyster L, McKnight CJ. Slow motions in chicken villin headpiece subdomain probed by cross-correlated NMR relaxation of amide NH bonds in successive residues. Biophys J. 2008 Dec 15; 95(12):5941-50. PMID: 18820237.
      View in: PubMed
    50. Vugmeyster L, Perazzolo C, Wist J, Frueh D, Bodenhausen G. Evidence of slow motions by cross-correlated chemical shift modulation in deuterated and protonated proteins. J Biomol NMR. 2004 Feb; 28(2):173-7. PMID: 14755161.
      View in: PubMed
    51. Vugmeyster L, Raleigh DP, Palmer AG, Vugmeister BE. Beyond the decoupling approximation in the model free approach for the interpretation of NMR relaxation of macromolecules in solution. J Am Chem Soc. 2003 Jul 09; 125(27):8400-4. PMID: 12837113.
      View in: PubMed
    52. Wang M, Tang Y, Sato S, Vugmeyster L, McKnight CJ, Raleigh DP. Dynamic NMR line-shape analysis demonstrates that the villin headpiece subdomain folds on the microsecond time scale. J Am Chem Soc. 2003 May 21; 125(20):6032-3. PMID: 12785814.
      View in: PubMed
    53. Vugmeyster L, Trott O, McKnight CJ, Raleigh DP, Palmer AG. Temperature-dependent dynamics of the villin headpiece helical subdomain, an unusually small thermostable protein. J Mol Biol. 2002 Jul 19; 320(4):841-54. PMID: 12095260.
      View in: PubMed
    54. Vugmeyster L, Kuhlman B, Raleigh DP. Amide proton exchange measurements as a probe of the stability and dynamics of the N-terminal domain of the ribosomal protein L9: comparison with the intact protein. Protein Sci. 1998 Sep; 7(9):1994-7. PMID: 9761480.
      View in: PubMed
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