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Sara Lea Sawyer

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction

    Collapse Research 
    Collapse research activities and funding
    R01GM093086     (SAWYER, SARA)Apr 1, 2010 - Oct 31, 2016
    Rapid evolution of genes critical for genome integrity
    Role: Principal Investigator

    R01AI137011     (SAWYER, SARA)Jan 10, 2018 - Dec 31, 2022
    Host genetic barriers to virus spillover
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Meyerson NR, Warren CJ, Vieira DASA, Diaz-Griferro F, Sawyer SL. Species-specific vulnerability of RanBP2 shaped the evolution of SIV as it transmitted in African apes. PLoS Pathog. 2018 Mar; 14(3):e1006906. PMID: 29518153.
      View in: PubMed
    2. Hamilton A, Smith E, Hamon J, Tomiak E, Bassal M, Sawyer SL. Using family history forms in pediatric oncology to identify patients for genetic assessment. Curr Oncol. 2017 Dec; 24(6):e441-e445. PMID: 29270053.
      View in: PubMed
    3. Nahabedian J, Sharma A, Kaczmarek ME, Wilkerson GK, Sawyer SL, Overbaugh J. Owl monkey CCR5 reveals synergism between CD4 and CCR5 in HIV-1 entry. Virology. 2017 12; 512:180-186. PMID: 28972927.
      View in: PubMed
    4. Balci TB, Davila J, Lewis D, Boafo A, Sell E, Richer J, Nikkel SM, Armour CM, Tomiak E, Lines MA, Sawyer SL. Broad spectrum of neuropsychiatric phenotypes associated with white matter disease in PTEN hamartoma tumor syndrome. Am J Med Genet B Neuropsychiatr Genet. 2018 Jan; 177(1):101-109. PMID: 29152901.
      View in: PubMed
    5. Meyerson NR, Zhou L, Guo YR, Zhao C, Tao YJ, Krug RM, Sawyer SL. Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation. Cell Host Microbe. 2017 Nov 08; 22(5):627-638.e7. PMID: 29107643.
      View in: PubMed
    6. Ylikallio E, Woldegebriel R, Tumiati M, Isohanni P, Ryan MM, Stark Z, Walsh M, Sawyer SL, Bell KM, Oshlack A, Lockhart PJ, Shcherbii M, Estrada-Cuzcano A, Atkinson D, Hartley T, Tetreault M, Cuppen I, van der Pol WL, Candayan A, Battaloglu E, Parman Y, van Gassen KLI, van den Boogaard MH, Boycott KM, Kauppi L, Jordanova A, Lönnqvist T, Tyynismaa H. MCM3AP in recessive Charcot-Marie-Tooth neuropathy and mild intellectual disability. Brain. 2017 Aug 01; 140(8):2093-2103. PMID: 28633435.
      View in: PubMed
    7. Kernohan KD, Grynspan D, Ramphal R, Bareke E, Wang YC, Nizalik E, Ragoussis J, Jabado N, Boycott KM, Majewski J, Sawyer SL. H3.1 K36M mutation in a congenital-onset soft tissue neoplasm. Pediatr Blood Cancer. 2017 Dec; 64(12). PMID: 28509377.
      View in: PubMed
    8. Malam F, Hartley T, Gillespie MK, Armour CM, Bariciak E, Graham GE, Nikkel SM, Richer J, Sawyer SL, Boycott KM, Dyment DA. Benchmarking outcomes in the Neonatal Intensive Care Unit: Cytogenetic and molecular diagnostic rates in a retrospective cohort. Am J Med Genet A. 2017 May 09. PMID: 28488422.
      View in: PubMed
    9. Stabell AC, Hawkins J, Li M, Gao X, David M, Press WH, Sawyer SL. Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins. PLoS Pathog. 2016 Dec; 12(12):e1006066. PMID: 28027315.
      View in: PubMed
    10. White TE, Brandariz-Nuñez A, Han K, Sawyer SL, Kim B, Diaz-Griffero F. Modulation of LINE-1 Retrotransposition by a Human SAMHD1 Polymorphism. Virol Rep. 2016 Dec; 6:53-60. PMID: 27482511.
      View in: PubMed
    11. Rowley PA, Ho B, Bushong S, Johnson A, Sawyer SL. XRN1 Is a Species-Specific Virus Restriction Factor in Yeasts. PLoS Pathog. 2016 Oct; 12(10):e1005890. PMID: 27711183.
      View in: PubMed
    12. Lou DI, Kim ET, Meyerson NR, Pancholi NJ, Mohni KN, Enard D, Petrov DA, Weller SK, Weitzman MD, Sawyer SL. An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates. Cell Host Microbe. 2016 Aug 10; 20(2):178-88. PMID: 27512903; PMCID: PMC4982468 [Available on 08/10/17].
    13. Wilke CO, Sawyer SL. At the mercy of viruses. Elife. 2016 May 17; 5. PMID: 27187565; PMCID: PMC4869909.
    14. Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, De Jay N, Papillon-Cavanagh S, Andrulis IL, Sawyer SL, Grynspan D, Turcotte RE, Nadaf J, Fahiminiyah S, Muir TW, Majewski J, Thompson CB, Chi P, Garcia BA, Allis CD, Jabado N, Lewis PW. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016 May 13; 352(6287):844-9. PMID: 27174990; PMCID: PMC4928577.
    15. Armour CM, Smith A, Hartley T, Chardon JW, Sawyer S, Schwartzentruber J, Hennekam R, Majewski J, Bulman DE, Suri M, Boycott KM. Syndrome disintegration: Exome sequencing reveals that Fitzsimmons syndrome is a co-occurrence of multiple events. Am J Med Genet A. 2016 Jul; 170(7):1820-5. PMID: 27133561.
      View in: PubMed
    16. Nepveu-Traversy MÉ, Demogines A, Fricke T, Plourde MB, Riopel K, Veillette M, Diaz-Griffero F, Sawyer SL, Berthoux L. A putative SUMO interacting motif in the B30.2/SPRY domain of rhesus macaque TRIM5a important for NF-?B/AP-1 signaling and HIV-1 restriction. Heliyon. 2016 Jan; 2(1):e00056. PMID: 27441239; PMCID: PMC4945854.
    17. Ng M, Ndungo E, Kaczmarek ME, Herbert AS, Binger T, Kuehne AI, Jangra RK, Hawkins JA, Gifford RJ, Biswas R, Demogines A, James RM, Yu M, Brummelkamp TR, Drosten C, Wang LF, Kuhn JH, Müller MA, Dye JM, Sawyer SL, Chandran K. Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats. Elife. 2015 Dec 23; 4. PMID: 26698106; PMCID: PMC4709267.
    18. Ferreira P, Luco SM, Sawyer SL, Davila J, Boycott KM, Dyment DA. Late diagnosis of cerebral folate deficiency: Fewer seizures with folinic acid in adult siblings. Neurol Genet. 2016 Feb; 2(1):e38. PMID: 27066576; PMCID: PMC4817904.
    19. Hussmann JA, Patchett S, Johnson A, Sawyer S, Press WH. Understanding Biases in Ribosome Profiling Experiments Reveals Signatures of Translation Dynamics in Yeast. PLoS Genet. 2015 Dec; 11(12):e1005732. PMID: 26656907; PMCID: PMC4684354.
    20. Avila M, Dyment DA, Sagen JV, St-Onge J, Moog U, Chung BH, Mansour S, Albanese A, Garcia S, Ortiz Martin D, Lopez AA, Claudi T, König R, White SM, Sawyer SL, Bernstein JA, Slattery L, Jobling RK, Yoon G, Curry CJ, Le Merrer M, Le Luyer B, Héron D, Mathieu-Dramard M, Bitoun P, Odent S, Amiel J, Kuentz P, Thevenon J, Laville M, Reznik Y, Fagour C, Nunes ML, Delesalle D, Manouvrier S, Lascols O, Huet F, Binquet C, Faivre L, Rivière JB, Vigouroux C, Njølstad PR, Innes AM, Thauvin-Robinet C. Clinical reappraisal of SHORT syndrome with PIK3R1 mutations: towards recommendation for molecular testing and management. Clin Genet. 2015 Oct 24. PMID: 26497935.
      View in: PubMed
    21. Sawyer SL, Hartley T, Dyment DA, Beaulieu CL, Schwartzentruber J, Smith A, Bedford HM, Bernard G, Bernier FP, Brais B, Bulman DE, Warman Chardon J, Chitayat D, Deladoëy J, Fernandez BA, Frosk P, Geraghty MT, Gerull B, Gibson W, Gow RM, Graham GE, Green JS, Heon E, Horvath G, Innes AM, Jabado N, Kim RH, Koenekoop RK, Khan A, Lehmann OJ, Mendoza-Londono R, Michaud JL, Nikkel SM, Penney LS, Polychronakos C, Richer J, Rouleau GA, Samuels ME, Siu VM, Suchowersky O, Tarnopolsky MA, Yoon G, Zahir FR, Majewski J, Boycott KM. Utility of whole-exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care. Clin Genet. 2016 Mar; 89(3):275-84. PMID: 26283276.
      View in: PubMed
    22. Kerr SA, Jackson EL, Lungu OI, Meyer AG, Demogines A, Ellington AD, Georgiou G, Wilke CO, Sawyer SL. Computational and Functional Analysis of the Virus-Receptor Interface Reveals Host Range Trade-Offs in New World Arenaviruses. J Virol. 2015 Nov; 89(22):11643-53. PMID: 26355089; PMCID: PMC4645654.
    23. McDonell LM, Kernohan KD, Boycott KM, Sawyer SL. Receptor tyrosine kinase mutations in developmental syndromes and cancer: two sides of the same coin. Hum Mol Genet. 2015 Oct 15; 24(R1):R60-6. PMID: 26152202; PMCID: PMC4572000 [Available on 10/15/16].
    24. Sawyer SL, Cheuk-Him Ng A, Innes AM, Wagner JD, Dyment DA, Tetreault M, Majewski J, Boycott KM, Screaton RA, Nicholson G. Homozygous mutations in MFN2 cause multiple symmetric lipomatosis associated with neuropathy. Hum Mol Genet. 2015 Sep 15; 24(18):5109-14. PMID: 26085578.
      View in: PubMed
    25. Meyerson NR, Sharma A, Wilkerson GK, Overbaugh J, Sawyer SL. Identification of Owl Monkey CD4 Receptors Broadly Compatible with Early-Stage HIV-1 Isolates. J Virol. 2015 Aug; 89(16):8611-22. PMID: 26063421; PMCID: PMC4524261.
    26. James PA, Sawyer S, Boyle S, Young MA, Kovalenko S, Doherty R, McKinley J, Alsop K, Beshay V, Harris M, Fox S, Lindeman GJ, Mitchell G. Large genomic rearrangements in the familial breast and ovarian cancer gene BRCA1 are associated with an increased frequency of high risk features. Fam Cancer. 2015 Jun; 14(2):287-95. PMID: 25678442.
      View in: PubMed
    27. Balci TB, Sawyer SL, Davila J, Humphreys P, Dyment DA. Brain malformations in a patient with deletion 2p16.1: A refinement of the phenotype to BCL11A. Eur J Med Genet. 2015 Jun-Jul; 58(6-7):351-4. PMID: 25979662.
      View in: PubMed
    28. Liu H, Sawyer SL, Gos M, Grynspan D, Issa K, Ramphal R, Rotaru C, Majewski J, Boycott KM, Graham G, Bromwich M. Atypical fibrodysplasia ossificans progressiva diagnosed by whole-exome sequencing. Am J Med Genet A. 2015 Jun; 167(6):1337-41. PMID: 25899773.
      View in: PubMed
    29. McBee RM, Rozmiarek SA, Meyerson NR, Rowley PA, Sawyer SL. The effect of species representation on the detection of positive selection in primate gene data sets. Mol Biol Evol. 2015 Apr; 32(4):1091-6. PMID: 25556235; PMCID: PMC4379402.
    30. Sawyer SL, Tian L, Kähkönen M, Schwartzentruber J, Kircher M, Majewski J, Dyment DA, Innes AM, Boycott KM, Moreau LA, Moilanen JS, Greenberg RA. Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype. Cancer Discov. 2015 Feb; 5(2):135-42. PMID: 25472942; PMCID: PMC4320660.
    31. Dyment DA, Tétreault M, Beaulieu CL, Hartley T, Ferreira P, Chardon JW, Marcadier J, Sawyer SL, Mosca SJ, Innes AM, Parboosingh JS, Bulman DE, Schwartzentruber J, Majewski J, Tarnopolsky M, Boycott KM. Whole-exome sequencing broadens the phenotypic spectrum of rare pediatric epilepsy: a retrospective study. Clin Genet. 2015 Jul; 88(1):34-40. PMID: 25046240.
      View in: PubMed
    32. Lou DI, McBee RM, Le UQ, Stone AC, Wilkerson GK, Demogines AM, Sawyer SL. Rapid evolution of BRCA1 and BRCA2 in humans and other primates. BMC Evol Biol. 2014 Jul 11; 14:155. PMID: 25011685; PMCID: PMC4106182.
    33. Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong M. Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. PLoS Pathog. 2014 Jul; 10(7):e1004177. PMID: 25010769; PMCID: PMC4092145.
    34. White TE, Brandariz-Nuñez A, Valle-Casuso JC, Knowlton C, Kim B, Sawyer SL, Diaz-Griffero F. Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility. Virology. 2014 Jul; 460-461:34-44. PMID: 25010268; PMCID: PMC4101048.
    35. Hussmann JA, Lou DI, Sawyer SL, Press WH. Reply to Schmitt et al.: Data-filtering schemes for avoiding double-counting in circle sequencing. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):E1561. PMID: 24877228; PMCID: PMC4000828.
    36. Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, DeChene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, McCallie D, Szolovits P, Willard HF, Mendelsohn NJ, Temme R, Finkel RS, Yum SW, Medne L, Sunyaev SR, Adzhubey I, Cassa CA, de Bakker PI, Duzkale H, Dworzynski P, Fairbrother W, Francioli L, Funke BH, Giovanni MA, Handsaker RE, Lage K, Lebo MS, Lek M, Leshchiner I, MacArthur DG, McLaughlin HM, Murray MF, Pers TH, Polak PP, Raychaudhuri S, Rehm HL, Soemedi R, Stitziel NO, Vestecka S, Supper J, Gugenmus C, Klocke B, Hahn A, Schubach M, Menzel M, Biskup S, Freisinger P, Deng M, Braun M, Perner S, Smith RJ, Andorf JL, Huang J, Ryckman K, Sheffield VC, Stone EM, Bair T, Black-Ziegelbein EA, Braun TA, Darbro B, DeLuca AP, Kolbe DL, Scheetz TE, Shearer AE, Sompallae R, Wang K, Bassuk AG, Edens E, Mathews K, Moore SA, Shchelochkov OA, Trapane P, Bossler A, Campbell CA, Heusel JW, Kwitek A, Maga T, Panzer K, Wassink T, Van Daele D, Azaiez H, Booth K, Meyer N, Segal MM, Williams MS, Tromp G, White P, Corsmeier D, Fitzgerald-Butt S, Herman G, Lamb-Thrush D, McBride KL, Newsom D, Pierson CR, Rakowsky AT, Maver A, Lovrecic L, Palandacic A, Peterlin B, Torkamani A, Wedell A, Huss M, Alexeyenko A, Lindvall JM, Magnusson M, Nilsson D, Stranneheim H, Taylan F, Gilissen C, Hoischen A, van Bon B, Yntema H, Nelen M, Zhang W, Sager J, Zhang L, Blair K, Kural D, Cariaso M, Lennon GG, Javed A, Agrawal S, Ng PC, Sandhu KS, Krishna S, Veeramachaneni V, Isakov O, Halperin E, Friedman E, Shomron N, Glusman G, Roach JC, Caballero J, Cox HC, Mauldin D, Ament SA, Rowen L, Richards DR, San Lucas FA, Gonzalez-Garay ML, Caskey CT, Bai Y, Huang Y, Fang F, Zhang Y, Wang Z, Barrera J, Garcia-Lobo JM, González-Lamuño D, Llorca J, Rodriguez MC, Varela I, Reese MG, De La Vega FM, Kiruluta E, Cargill M, Hart RK, Sorenson JM, Lyon GJ, Stevenson DA, Bray BE, Moore BM, Eilbeck K, Yandell M, Zhao H, Hou L, Chen X, Yan X, Chen M, Li C, Yang C, Gunel M, Li P, Kong Y, Alexander AC, Albertyn ZI, Boycott KM, Bulman DE, Gordon PM, Innes AM, Knoppers BM, Majewski J, Marshall CR, Parboosingh JS, Sawyer SL, Samuels ME, Schwartzentruber J, Kohane IS, Margulies DM. An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol. 2014 Mar 25; 15(3):R53. PMID: 24667040; PMCID: PMC4073084.
    37. Meyerson NR, Rowley PA, Swan CH, Le DT, Wilkerson GK, Sawyer SL. Positive selection of primate genes that promote HIV-1 replication. Virology. 2014 Apr; 454-455:291-8. PMID: 24725956; PMCID: PMC4028154.
    38. Meyer AG, Sawyer SL, Ellington AD, Wilke CO. Analyzing machupo virus-receptor binding by molecular dynamics simulations. PeerJ. 2014; 2:e266. PMID: 24624315; PMCID: PMC3940602.
    39. Rosewich H, Ohlenbusch A, Huppke P, Schlotawa L, Baethmann M, Carrilho I, Fiori S, Lourenço CM, Sawyer S, Steinfeld R, Gärtner J, Brockmann K. The expanding clinical and genetic spectrum of ATP1A3-related disorders. Neurology. 2014 Mar 18; 82(11):945-55. PMID: 24523486.
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    40. Sawyer SL, Schwartzentruber J, Beaulieu CL, Dyment D, Smith A, Warman Chardon J, Yoon G, Rouleau GA, Suchowersky O, Siu V, Murphy L, Hegele RA, Marshall CR, Bulman DE, Majewski J, Tarnopolsky M, Boycott KM. Exome sequencing as a diagnostic tool for pediatric-onset ataxia. Hum Mutat. 2014 Jan; 35(1):45-9. PMID: 24108619; PMCID: PMC4255313.
    41. Boycott KM, Dyment DA, Sawyer SL, Vanstone MR, Beaulieu CL. Identification of genes for childhood heritable diseases. Annu Rev Med. 2014; 65:19-31. PMID: 24422568.
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    42. Lou DI, Hussmann JA, McBee RM, Acevedo A, Andino R, Press WH, Sawyer SL. High-throughput DNA sequencing errors are reduced by orders of magnitude using circle sequencing. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19872-7. PMID: 24243955; PMCID: PMC3856802.
    43. Dyment DA, Sawyer SL, Chardon JW, Boycott KM. Recent advances in the genetic etiology of brain malformations. Curr Neurol Neurosci Rep. 2013 Aug; 13(8):364. PMID: 23793931.
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    44. Abrams AJ, Cannatella DC, Hillis DM, Sawyer SL. Recent host-shifts in ranaviruses: signatures of positive selection in the viral genome. J Gen Virol. 2013 Sep; 94(Pt 9):2082-93. PMID: 23784445; PMCID: PMC3749056.
    45. Demogines A, Abraham J, Choe H, Farzan M, Sawyer SL. Dual host-virus arms races shape an essential housekeeping protein. PLoS Biol. 2013; 11(5):e1001571. PMID: 23723737; PMCID: PMC3665890.
    46. McDougle RM, Hultquist JF, Stabell AC, Sawyer SL, Harris RS. D316 is critical for the enzymatic activity and HIV-1 restriction potential of human and rhesus APOBEC3B. Virology. 2013 Jun 20; 441(1):31-9. PMID: 23542011; PMCID: PMC3752335.
    47. Sawyer SL, Dicke F, Kirton A, Rajapkse T, Rebeyka IM, McInnes B, Parboosingh JS, Bernier FP. Longer term survival of a child with autosomal recessive cutis laxa due to a mutation in FBLN4. Am J Med Genet A. 2013 May; 161A(5):1148-53. PMID: 23532871.
      View in: PubMed
    48. Voit RA, McMahon MA, Sawyer SL, Porteus MH. Generation of an HIV resistant T-cell line by targeted "stacking" of restriction factors. Mol Ther. 2013 Apr; 21(4):786-95. PMID: 23358186; PMCID: PMC3616536.
    49. Thompson ER, Rowley SM, Sawyer S, Eccles DM, Trainer AH, Mitchell G, James PA, Campbell IG. Analysis of RAD51D in ovarian cancer patients and families with a history of ovarian or breast cancer. PLoS One. 2013; 8(1):e54772. PMID: 23372765; PMCID: PMC3555982.
    50. Malfavon-Borja R, Sawyer SL, Wu LI, Emerman M, Malik HS. An evolutionary screen highlights canonical and noncanonical candidate antiviral genes within the primate TRIM gene family. Genome Biol Evol. 2013; 5(11):2141-54. PMID: 24158625; PMCID: PMC3845644.
    51. Sawyer S, Mitchell G, McKinley J, Chenevix-Trench G, Beesley J, Chen XQ, Bowtell D, Trainer AH, Harris M, Lindeman GJ, James PA. A role for common genomic variants in the assessment of familial breast cancer. J Clin Oncol. 2012 Dec 10; 30(35):4330-6. PMID: 23109704.
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    52. Sawyer SL, Elde NC. A cross-species view on viruses. Curr Opin Virol. 2012 Oct; 2(5):561-8. PMID: 22835485; PMCID: PMC3470745.
    53. Kaelber JT, Demogines A, Harbison CE, Allison AB, Goodman LB, Ortega AN, Sawyer SL, Parrish CR. Evolutionary reconstructions of the transferrin receptor of Caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs. PLoS Pathog. 2012; 8(5):e1002666. PMID: 22570610; PMCID: PMC3342950.
    54. Demogines A, Farzan M, Sawyer SL. Evidence for ACE2-utilizing coronaviruses (CoVs) related to severe acute respiratory syndrome CoV in bats. J Virol. 2012 Jun; 86(11):6350-3. PMID: 22438550; PMCID: PMC3372174.
    55. Lee K, Mulky A, Yuen W, Martin TD, Meyerson NR, Choi L, Yu H, Sawyer SL, Kewalramani VN. HIV-1 capsid-targeting domain of cleavage and polyadenylation specificity factor 6. J Virol. 2012 Apr; 86(7):3851-60. PMID: 22301135; PMCID: PMC3302544.
    56. Han K, Lou DI, Sawyer SL. Identification of a genomic reservoir for new TRIM genes in primate genomes. PLoS Genet. 2011 Dec; 7(12):e1002388. PMID: 22144910; PMCID: PMC3228819.
    57. Thompson ER, Boyle SE, Johnson J, Ryland GL, Sawyer S, Choong DY, Chenevix-Trench G, Trainer AH, Lindeman GJ, Mitchell G, James PA, Campbell IG. Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients. Hum Mutat. 2012 Jan; 33(1):95-9. PMID: 21990120.
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    58. Demogines A, Truong KA, Sawyer SL. Species-specific features of DARC, the primate receptor for Plasmodium vivax and Plasmodium knowlesi. Mol Biol Evol. 2012 Feb; 29(2):445-9. PMID: 21878684; PMCID: PMC3258036.
    59. Meyerson NR, Sawyer SL. Two-stepping through time: mammals and viruses. Trends Microbiol. 2011 Jun; 19(6):286-94. PMID: 21531564; PMCID: PMC3567447.
    60. Callard GV, Tarrant AM, Novillo A, Yacci P, Ciaccia L, Vajda S, Chuang GY, Kozakov D, Greytak SR, Sawyer S, Hoover C, Cotter KA. Evolutionary origins of the estrogen signaling system: insights from amphioxus. J Steroid Biochem Mol Biol. 2011 Nov; 127(3-5):176-88. PMID: 21514383; PMCID: PMC3179578.
    61. Demogines A, East AM, Lee JH, Grossman SR, Sabeti PC, Paull TT, Sawyer SL. Ancient and recent adaptive evolution of primate non-homologous end joining genes. PLoS Genet. 2010 Oct 21; 6(10):e1001169. PMID: 20975951; PMCID: PMC2958818.
    62. Johnson WE, Sawyer SL. Molecular evolution of the antiretroviral TRIM5 gene. Immunogenetics. 2009 Mar; 61(3):163-76. PMID: 19238338.
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    63. Tareen SU, Sawyer SL, Malik HS, Emerman M. An expanded clade of rodent Trim5 genes. Virology. 2009 Mar 15; 385(2):473-83. PMID: 19147168; PMCID: PMC2692226.
    64. Sawyer SL, Emerman M, Malik HS. Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals. PLoS Pathog. 2007 Dec; 3(12):e197. PMID: 18159944; PMCID: PMC2151084.
    65. Sawyer SL, Malik HS. Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17614-9. PMID: 17101967; PMCID: PMC1693795.
    66. Fredman D, Sawyer SL, Strömqvist L, Mottagui-Tabar S, Kidd KK, Wahlestedt C, Chanock SJ, Brookes AJ. Nonsynonymous SNPs: validation characteristics, derived allele frequency patterns, and suggestive evidence for natural selection. Hum Mutat. 2006 Feb; 27(2):173-86. PMID: 16429399.
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    67. Sawyer SL, Wu LI, Akey JM, Emerman M, Malik HS. High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans. Curr Biol. 2006 Jan 10; 16(1):95-100. PMID: 16401428.
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    68. Sawyer SL, Mukherjee N, Pakstis AJ, Feuk L, Kidd JR, Brookes AJ, Kidd KK. Linkage disequilibrium patterns vary substantially among populations. Eur J Hum Genet. 2005 May; 13(5):677-86. PMID: 15657612.
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    69. Sawyer SL, Wu LI, Emerman M, Malik HS. Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2832-7. PMID: 15689398; PMCID: PMC549489.
    70. Liu N, Sawyer SL, Mukherjee N, Pakstis AJ, Kidd JR, Kidd KK, Brookes AJ, Zhao H. Haplotype block structures show significant variation among populations. Genet Epidemiol. 2004 Dec; 27(4):385-400. PMID: 15389924.
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    71. Sawyer SL, Emerman M, Malik HS. Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G. PLoS Biol. 2004 Sep; 2(9):E275. PMID: 15269786; PMCID: PMC479043.
    72. Sawyer SL, Cheng IH, Chai W, Tye BK. Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae. J Mol Biol. 2004 Jul 02; 340(2):195-202. PMID: 15201046.
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    73. Sawyer SL, Berglind LC, Brookes AJ. Negligible validation rate for public domain stop-codon SNPs. Hum Mutat. 2003 Sep; 22(3):252-4. PMID: 12938090.
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    74. Sawyer SL, Howell WM, Brookes AJ. Scoring insertion-deletion polymorphisms by dynamic allele-specific hybridization. Biotechniques. 2003 Aug; 35(2):292-6, 298. PMID: 12951770.
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    75. Naidu RA, Sawyer S, Deom CM. Molecular diversity of RNA-2 genome segments in pecluviruses causing peanut clump disease in West Africa and India. Arch Virol. 2003 Jan; 148(1):83-98. PMID: 12536297.
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    76. Emahazion T, Feuk L, Jobs M, Sawyer SL, Fredman D, St Clair D, Prince JA, Brookes AJ. SNP association studies in Alzheimer's disease highlight problems for complex disease analysis. Trends Genet. 2001 Jul; 17(7):407-13. PMID: 11418222.
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    77. Prince JA, Feuk L, Sawyer SL, Gottfries J, Ricksten A, Nägga K, Bogdanovic N, Blennow K, Brookes AJ. Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. Eur J Hum Genet. 2001 Jun; 9(6):437-44. PMID: 11436125.
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    78. Tye BK, Sawyer S. The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts. J Biol Chem. 2000 Nov 10; 275(45):34833-6. PMID: 10980206.
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    79. Homesley L, Lei M, Kawasaki Y, Sawyer S, Christensen T, Tye BK. Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins. Genes Dev. 2000 Apr 15; 14(8):913-26. PMID: 10783164; PMCID: PMC316538.
    80. Padidam M, Sawyer S, Fauquet CM. Possible emergence of new geminiviruses by frequent recombination. Virology. 1999 Dec 20; 265(2):218-25. PMID: 10600594.
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    81. Geiger KD, Nash TC, Sawyer S, Krahl T, Patstone G, Reed JC, Krajewski S, Dalton D, Buchmeier MJ, Sarvetnick N. Interferon-gamma protects against herpes simplex virus type 1-mediated neuronal death. Virology. 1997 Nov 24; 238(2):189-97. PMID: 9400592.
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    82. Ruscetti S, Aurigemma R, Yuan CC, Sawyer S, Blair DG. Induction of erythropoietin responsiveness in murine hematopoietic cells by the gag-myb-ets-containing ME26 virus. J Virol. 1992 Jan; 66(1):20-6. PMID: 1309243; PMCID: PMC238255.
    83. Sawyer S. Statistical tests for detecting gene conversion. Mol Biol Evol. 1989 Sep; 6(5):526-38. PMID: 2677599.
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