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Search Results to Timothy A McKinsey

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McKinsey, Timothy

One or more keywords matched the following items that are connected to McKinsey, Timothy

Item Type	Name
Academic Article	Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases.
Academic Article	Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation.
Academic Article	Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors.
Academic Article	Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.
Academic Article	Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation.
Academic Article	Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes.
Academic Article	Protein kinase D directly phosphorylates histone deacetylase 5 via a random sequential kinetic mechanism.
Academic Article	Control of cardiac hypertrophy and heart failure by histone acetylation/deacetylation.
Academic Article	Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis.
Academic Article	YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5.
Academic Article	Identification of orally available naphthyridine protein kinase D inhibitors.
Academic Article	Isoform-selective HDAC inhibitors: closing in on translational medicine for the heart.
Academic Article	Targeting inflammation in heart failure with histone deacetylase inhibitors.
Academic Article	Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases.
Academic Article	Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension.
Academic Article	Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5.
Academic Article	Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension.
Academic Article	Therapeutic potential for HDAC inhibitors in the heart.
Academic Article	Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism.
Academic Article	Roles of histone deacetylation and AMP kinase in regulation of cardiomyocyte PGC-1a gene expression in hypoxia.
Academic Article	Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy.
Academic Article	Signaling chromatin to make muscle.
Academic Article	Cardiac histone acetylation--therapeutic opportunities abound.
Academic Article	Dual roles of histone deacetylases in the control of cardiac growth.
Academic Article	Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK.
Academic Article	Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor.
Academic Article	Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5.
Academic Article	The CRM1 nuclear export receptor controls pathological cardiac gene expression.
Academic Article	Toward transcriptional therapies for the failing heart: chemical screens to modulate genes.
Academic Article	Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy.
Academic Article	Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling.
Academic Article	Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.
Academic Article	Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4.
Academic Article	Derepression of pathological cardiac genes by members of the CaM kinase superfamily.
Academic Article	Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1.
Academic Article	A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase.
Academic Article	Protein acetylation in the cardiorenal axis: the promise of histone deacetylase inhibitors.
Academic Article	Targeting histone deacetylases for heart failure.
Academic Article	3,5-diarylazoles as novel and selective inhibitors of protein kinase D.
Academic Article	Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases.
Academic Article	Increased phosphorylation-dependent nuclear export of class II histone deacetylases in failing human heart.
Academic Article	Identification of potent and selective amidobipyridyl inhibitors of protein kinase D.
Academic Article	?-Adrenergic receptor stimulation and activation of protein kinase A protect against a1-adrenergic-mediated phosphorylation of protein kinase D and histone deacetylase 5.
Academic Article	The biology and therapeutic implications of HDACs in the heart.
Academic Article	Response to letter regarding article, ?histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid?.
Academic Article	Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
Concept	Histone Deacetylase 1
Concept	Histone Code
Concept	Histone Deacetylase Inhibitors
Concept	Histone Acetyltransferases
Concept	Jumonji Domain-Containing Histone Demethylases
Concept	Histone Deacetylases
Concept	Histone Deacetylase 2
Concept	Histones
Academic Article	MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts.
Academic Article	Estrogen regulates histone deacetylases to prevent cardiac hypertrophy.
Academic Article	Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes.
Academic Article	Targeting cardiac fibroblasts to treat fibrosis of the heart: focus on HDACs.
Academic Article	HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling.
Academic Article	Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy.
Academic Article	Class I HDAC inhibition stimulates cardiac protein SUMOylation through a post-translational mechanism.
Academic Article	Acetyl-lysine erasers and readers in the control of pulmonary hypertension and right ventricular hypertrophy.
Academic Article	Promiscuous actions of small molecule inhibitors of the protein kinase D-class IIa HDAC axis in striated muscle.
Academic Article	Emerging roles for histone deacetylases in pulmonary hypertension and right ventricular remodeling (2013 Grover Conference series).
Academic Article	Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement.
Academic Article	Non-sirtuin histone deacetylases in the control of cardiac aging.
Academic Article	Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression.
Academic Article	Myofibril growth during cardiac hypertrophy is regulated through dual phosphorylation and acetylation of the actin capping protein CapZ.
Academic Article	Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension.
Academic Article	The potential of targeting epigenetic regulators for the treatment of fibrotic cardiac diseases.
Academic Article	Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes.
Academic Article	Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts.
Grant	Isoform-Selective HDAC Inhibitors for Age-Associated Diastolic Dysfunction
Grant	Regulation of Cardiac Signaling by Class I Histone Deacetylases
Grant	The Role of Histone Deacytelases in Right Ventricular Adaptation in Hypoplastic L
Academic Article	Histone deacetylase adaptation in single ventricle heart disease and a young animal model of right ventricular hypertrophy.
Academic Article	Class I HDACs control a JIP1-dependent pathway for kinesin-microtubule binding in cardiomyocytes.
Academic Article	Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism.
Academic Article	HDAC11 suppresses the thermogenic program of adipose tissue via BRD2.
Academic Article	Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture.
Concept	Histone Deacetylase 6
Academic Article	HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression.
Academic Article	HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction.
Academic Article	The black sheep of class IIa: HDAC7 SIKens the heart.
Academic Article	Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor.
Academic Article	Suppression of canonical TGF-? signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis.
Academic Article	Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition.
Academic Article	HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling.
Academic Article	Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity.
Academic Article	Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling.
Academic Article	HDAC6 modulates myofibril stiffness and diastolic function of the heart.
Academic Article	Histone Deacetylases: Molecular Mechanisms and Therapeutic Implications for Muscular Dystrophies.
Academic Article	HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance.

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Histones