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Search Results to Charles A Dinarello

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Dinarello, Charles

One or more keywords matched the following items that are connected to Dinarello, Charles

Item Type	Name
Academic Article	Human monocyte-derived soluble product(s) has an accessory function in the generation of histamine- and concanavalin A-induced suppressor T cells.
Academic Article	Fibroblast stimulation in schistosomiasis. V. Egg granuloma macrophages spontaneously secrete a fibroblast-stimulating factor.
Academic Article	Induction of human interleukin-1 by a product of Staphylococcus aureus associated with toxic shock syndrome.
Academic Article	Ability of human leukocytic pyrogen to enhance phytohemagglutinin induced murine thymocyte proliferation.
Academic Article	Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases.
Academic Article	Interleukin-1 receptor antagonist inhibits subcutaneous B16 melanoma growth in vivo.
Academic Article	Effect of endotoxin in IL-1 beta-deficient mice.
Academic Article	[Demonstration of a bacterial structure in two human mediators: a sleep facilitating factor and a monokine].
Academic Article	IL-1 beta mediates leptin induction during inflammation.
Academic Article	Differential effects of interleukin-1 and tumor necrosis factor on ketogenesis.
Academic Article	Leptin deficiency enhances sensitivity to endotoxin-induced lethality.
Academic Article	Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18.
Academic Article	Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia.
Academic Article	Role of interferon regulatory factor-1 in the regulation of IL-18 production and activity.
Academic Article	Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production.
Academic Article	Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways.
Academic Article	Role of interleukin-18 in host defense against disseminated Candida albicans infection.
Academic Article	Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction.
Academic Article	Interleukin-6 as an endogenous pyrogen: induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells.
Academic Article	GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccines.
Academic Article	Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein.
Academic Article	Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis.
Academic Article	Interleukin-18 does not modulate the acute-phase response.
Academic Article	Induction of thymocyte apoptosis by systemic administration of concanavalin A in mice: role of TNF-alpha, IFN-gamma and glucocorticoids.
Academic Article	Melanoma inhibits macrophage activation by suppressing toll-like receptor 4 signaling.
Academic Article	T cell-mediated hepatic inflammation modulates adiponectin levels in mice: role of tumor necrosis factor alpha.
Academic Article	Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney.
Academic Article	Differential role and tissue specificity of interleukin-1alpha gene expression in atherogenesis and lipid metabolism.
Academic Article	The interaction between myocardial depressant factors in endotoxemic cardiac dysfunction: role of TNF-alpha in TLR4-mediated ICAM-1 expression.
Academic Article	Eukaryotic translation initiation factor 5A small interference RNA-liposome complexes reduce inflammation and increase survival in murine models of severe sepsis and acute lung injury.
Academic Article	Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury.
Academic Article	Identification of the most active interleukin-32 isoform.
Academic Article	Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3.
Academic Article	IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis.
Academic Article	Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis.
Academic Article	IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2.
Academic Article	Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1a.
Academic Article	The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet ? cells in vivo and in vitro.
Academic Article	Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages.
Academic Article	Inhibition of IL-32 activation by a-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.
Academic Article	IL-1a and IL-1? recruit different myeloid cells and promote different stages of sterile inflammation.
Academic Article	?2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo.
Academic Article	Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1a.
Academic Article	Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury.
Academic Article	Role of IL-18 in second-hand smoke-induced emphysema.
Academic Article	Cleavage of human interleukin 1: isolation of a peptide fragment from plasma of febrile humans and activated monocytes.
Academic Article	IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease.
Academic Article	Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone.
Academic Article	Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice.
Academic Article	Evidence for two classes of cytokines that stimulate hepatic lipogenesis: relationships among tumor necrosis factor, interleukin-1 and interferon-alpha.
Academic Article	Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock.
Academic Article	Histone hyperacetylation is associated with amelioration of experimental colitis in mice.
Academic Article	Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.
Academic Article	An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis.
Academic Article	Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury.
Academic Article	Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia.
Academic Article	Interleukin-18 binding protein reduces b16 melanoma hepatic metastasis by neutralizing adhesiveness and growth factors of sinusoidal endothelium.
Academic Article	IL-1 is required for tumor invasiveness and angiogenesis.
Academic Article	Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice.
Academic Article	Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice.
Academic Article	Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor.
Academic Article	Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice.
Academic Article	Differential susceptibility to lethal endotoxaemia in mice deficient in IL-1a, IL-1? or IL-1 receptor type I.
Academic Article	Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo.
Academic Article	alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice.
Academic Article	Lack of interleukin-1a or interleukin-1? inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice.
Academic Article	The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis.
Academic Article	Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
Academic Article	Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation.
Academic Article	The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.
Academic Article	The pathogenic Th17 cell response to major schistosome egg antigen is sequentially dependent on IL-23 and IL-1?.
Academic Article	Phorbol myristate acetate-protein complex mimics bioactivity of human IL-1. 1. Direct evidence that PMA temporarily enters and is released from cellular compartment during superinduction protocol.
Academic Article	Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation.
Academic Article	Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Concept	Mice, Inbred C57BL
Academic Article	Anti-inflammatory and immunomodulatory properties of a1-antitrypsin without inhibition of elastase.
Academic Article	Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and ?-cell protection.
Academic Article	Interleukin-18 mediates interleukin-1-induced cardiac dysfunction.
Academic Article	IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans.
Academic Article	Non-redundant properties of IL-1a and IL-1? during acute colon inflammation in mice.
Academic Article	a-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics.
Academic Article	Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells.
Academic Article	Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo.
Academic Article	IL-1a is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity.
Academic Article	IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis.
Academic Article	Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1? and by the induction of endogenous IL-1Ra.
Academic Article	Novel strategies for targeting innate immune responses to influenza.
Academic Article	Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation.
Academic Article	Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice.
Academic Article	Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice.
Academic Article	Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance.
Academic Article	Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.
Academic Article	IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia.
Academic Article	IL-32? promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis.
Academic Article	Ethanol-mediated suppression of IL-37 licenses alcoholic liver disease.
Academic Article	OLT1177, a ?-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Academic Article	NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis.
Academic Article	IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake.
Academic Article	TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization.
Academic Article	Blocking IL-1? reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation.
Academic Article	Role for nuclear interleukin-37 in the suppression of innate immunity.
Academic Article	IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease.
Academic Article	OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis.
Academic Article	Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis.
Academic Article	Alpha-1 antitrypsin governs alcohol-related liver disease in mice and humans.
Academic Article	IL-37 Expression Is Downregulated in Lesional Psoriasis Skin.
Academic Article	Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease.
Academic Article	Interleukin-37 improves T-cell-mediated immunity and chimeric antigen receptor T-cell therapy in aged backgrounds.
Academic Article	IL-38 prevents induction of trained immunity by inhibition of mTOR signaling.
Academic Article	The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity.
Academic Article	Tumor NLRP3-Derived IL-1? Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression.
Academic Article	Interleukin-1 Receptor Antagonism Abrogates Acute Pressure Overload-Induced Murine Heart Failure.
Academic Article	The NLRP3 inflammasome inhibitor, OLT1177? , ameliorates experimental allergic asthma in mice.
Academic Article	IL-38 Gene Deletion Worsens Murine Colitis.
Academic Article	Pharmacologic inhibition of NLRP3 reduces the levels of a-synuclein and protects dopaminergic neurons in a model of Parkinson's disease.

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Mice Inbred C57BL