Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension.
Hu CJ, Poth JM, Zhang H, Flockton A, Laux A, Kumar S, McKeon B, Mouradian G, Li M, Riddle S, Pugliese SC, Brown RD, Wallace EM, Graham BB, Frid MG, Stenmark KR. Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension. Eur Respir J. 2019 12; 54(6).
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Animals
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Basic Helix-Loop-Helix Transcription Factors
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Cell Proliferation
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Cells, Cultured
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Disease Models, Animal
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Endothelial Cells
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Female
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Gene Expression Regulation
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Hypertension, Pulmonary
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Hypertrophy, Right Ventricular
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Hypoxia
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Muscle, Smooth, Vascular
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Myocytes, Smooth Muscle
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Pulmonary Artery
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Rats
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Rats, Sprague-Dawley
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Signal Transduction
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Vascular Remodeling