 Connection
Joseph Falke to Signal Transduction
This is a "connection" page, showing publications Joseph Falke has written about Signal Transduction.
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Connection Strength |
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3.476 |
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Gordon MT, Ziemba BP, Falke JJ. Single-molecule studies reveal regulatory interactions between master kinases PDK1, AKT1, and PKC. Biophys J. 2021 12 21; 120(24):5657-5673.
Score: 0.315
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Ziemba BP, Falke JJ. A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages. PLoS One. 2018; 13(5):e0196678.
Score: 0.247
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Buckles TC, Ziemba BP, Masson GR, Williams RL, Falke JJ. Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Ka and PIP3 Signaling. Biophys J. 2017 Dec 05; 113(11):2396-2405.
Score: 0.241
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Ziemba BP, Swisher GH, Masson G, Burke JE, Williams RL, Falke JJ. Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module. Biochemistry. 2016 Nov 22; 55(46):6395-6405.
Score: 0.223
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Ziemba BP, Burke JE, Masson G, Williams RL, Falke JJ. Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway. Biophys J. 2016 04 26; 110(8):1811-1825.
Score: 0.215
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Parkinson JS, Hazelbauer GL, Falke JJ. Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update. Trends Microbiol. 2015 May; 23(5):257-66.
Score: 0.200
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Falke JJ, Piasta KN. Architecture and signal transduction mechanism of the bacterial chemosensory array: progress, controversies, and challenges. Curr Opin Struct Biol. 2014 Dec; 29:85-94.
Score: 0.194
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Swain KE, Gonzalez MA, Falke JJ. Engineered socket study of signaling through a four-helix bundle: evidence for a yin-yang mechanism in the kinase control module of the aspartate receptor. Biochemistry. 2009 Oct 06; 48(39):9266-77.
Score: 0.137
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Erbse AH, Falke JJ. The core signaling proteins of bacterial chemotaxis assemble to form an ultrastable complex. Biochemistry. 2009 Jul 28; 48(29):6975-87.
Score: 0.135
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Miller AS, Kohout SC, Gilman KA, Falke JJ. CheA Kinase of bacterial chemotaxis: chemical mapping of four essential docking sites. Biochemistry. 2006 Jul 25; 45(29):8699-711.
Score: 0.109
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Coleman MD, Bass RB, Mehan RS, Falke JJ. Conserved glycine residues in the cytoplasmic domain of the aspartate receptor play essential roles in kinase coupling and on-off switching. Biochemistry. 2005 May 31; 44(21):7687-95.
Score: 0.101
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Miller AS, Falke JJ. Side chains at the membrane-water interface modulate the signaling state of a transmembrane receptor. Biochemistry. 2004 Feb 24; 43(7):1763-70.
Score: 0.093
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Miller AF, Falke JJ. Chemotaxis receptors and signaling. Adv Protein Chem. 2004; 68:393-444.
Score: 0.092
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Bornhorst JA, Falke JJ. Quantitative analysis of aspartate receptor signaling complex reveals that the homogeneous two-state model is inadequate: development of a heterogeneous two-state model. J Mol Biol. 2003 Mar 07; 326(5):1597-614.
Score: 0.087
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Gordon MT, Ziemba BP, Falke JJ. PDK1:PKCa heterodimer association-dissociation dynamics in single-molecule diffusion tracks on a target membrane. Biophys J. 2023 06 06; 122(11):2301-2310.
Score: 0.086
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Falke JJ, Hazelbauer GL. Transmembrane signaling in bacterial chemoreceptors. Trends Biochem Sci. 2001 Apr; 26(4):257-65.
Score: 0.076
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Bass RB, Coleman MD, Falke JJ. Signaling domain of the aspartate receptor is a helical hairpin with a localized kinase docking surface: cysteine and disulfide scanning studies. Biochemistry. 1999 Jul 20; 38(29):9317-27.
Score: 0.067
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Bass RB, Falke JJ. Detection of a conserved alpha-helix in the kinase-docking region of the aspartate receptor by cysteine and disulfide scanning. J Biol Chem. 1998 Sep 25; 273(39):25006-14.
Score: 0.064
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Nalefski EA, Slazas MM, Falke JJ. Ca2+-signaling cycle of a membrane-docking C2 domain. Biochemistry. 1997 Oct 07; 36(40):12011-8.
Score: 0.059
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Falke JJ, Bass RB, Butler SL, Chervitz SA, Danielson MA. The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors, kinases, and adaptation enzymes. Annu Rev Cell Dev Biol. 1997; 13:457-512.
Score: 0.056
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Chervitz SA, Falke JJ. Molecular mechanism of transmembrane signaling by the aspartate receptor: a model. Proc Natl Acad Sci U S A. 1996 Mar 19; 93(6):2545-50.
Score: 0.053
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Chervitz SA, Falke JJ. Lock on/off disulfides identify the transmembrane signaling helix of the aspartate receptor. J Biol Chem. 1995 Oct 13; 270(41):24043-53.
Score: 0.052
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Chervitz SA, Lin CM, Falke JJ. Transmembrane signaling by the aspartate receptor: engineered disulfides reveal static regions of the subunit interface. Biochemistry. 1995 Aug 01; 34(30):9722-33.
Score: 0.051
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Falke JJ, Blair DF, Silhavy TJ, Schmitt R. BLAST 1995: international conference on bacterial locomotion and signal transduction. Mol Microbiol. 1995 Jun; 16(6):1037-50.
Score: 0.051
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Piasta KN, Falke JJ. Increasing and decreasing the ultrastability of bacterial chemotaxis core signaling complexes by modifying protein-protein contacts. Biochemistry. 2014 Sep 09; 53(35):5592-600.
Score: 0.048
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Falke JJ, Drake SK, Hazard AL, Peersen OB. Molecular tuning of ion binding to calcium signaling proteins. Q Rev Biophys. 1994 Aug; 27(3):219-90.
Score: 0.048
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Natale AM, Duplantis JL, Piasta KN, Falke JJ. Structure, function, and on-off switching of a core unit contact between CheA kinase and CheW adaptor protein in the bacterial chemosensory array: A disulfide mapping and mutagenesis study. Biochemistry. 2013 Nov 05; 52(44):7753-65.
Score: 0.045
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Renner M, Danielson MA, Falke JJ. Kinetic control of Ca(II) signaling: tuning the ion dissociation rates of EF-hand Ca(II) binding sites. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6493-7.
Score: 0.044
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Piasta KN, Ulliman CJ, Slivka PF, Crane BR, Falke JJ. Defining a key receptor-CheA kinase contact and elucidating its function in the membrane-bound bacterial chemosensory array: a disulfide mapping and TAM-IDS Study. Biochemistry. 2013 Jun 04; 52(22):3866-80.
Score: 0.044
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Slivka PF, Falke JJ. Isolated bacterial chemosensory array possesses quasi- and ultrastable components: functional links between array stability, cooperativity, and order. Biochemistry. 2012 Dec 21; 51(51):10218-28.
Score: 0.043
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Falke JJ, Erbse AH. The piston rises again. Structure. 2009 Sep 09; 17(9):1149-51.
Score: 0.034
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Endres RG, Falke JJ, Wingreen NS. Chemotaxis receptor complexes: from signaling to assembly. PLoS Comput Biol. 2007 Jul; 3(7):e150.
Score: 0.029
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Bass RB, Miller AS, Gloor SL, Falke JJ. The PICM chemical scanning method for identifying domain-domain and protein-protein interfaces: applications to the core signaling complex of E. coli chemotaxis. Methods Enzymol. 2007; 423:3-24.
Score: 0.028
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Bornhorst JA, Falke JJ. Evidence that both ligand binding and covalent adaptation drive a two-state equilibrium in the aspartate receptor signaling complex. J Gen Physiol. 2001 Dec; 118(6):693-710.
Score: 0.020
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Bornhorst JA, Falke JJ. Attractant regulation of the aspartate receptor-kinase complex: limited cooperative interactions between receptors and effects of the receptor modification state. Biochemistry. 2000 Aug 08; 39(31):9486-93.
Score: 0.018
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Falke JJ, Kim SH. Structure of a conserved receptor domain that regulates kinase activity: the cytoplasmic domain of bacterial taxis receptors. Curr Opin Struct Biol. 2000 Aug; 10(4):462-9.
Score: 0.018
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Butler SL, Falke JJ. Cysteine and disulfide scanning reveals two amphiphilic helices in the linker region of the aspartate chemoreceptor. Biochemistry. 1998 Jul 28; 37(30):10746-56.
Score: 0.016
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Drake SK, Zimmer MA, Kundrot C, Falke JJ. Molecular tuning of an EF-hand-like calcium binding loop. Contributions of the coordinating side chain at loop position 3. J Gen Physiol. 1997 Aug; 110(2):173-84.
Score: 0.015
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Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, Phipps S, Foster PS, Landgraf K, Falke JJ, Rice KC, Maier SF, Yin H, Watkins LR. Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience. 2010 Jun 30; 168(2):551-63.
Score: 0.009
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Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, Falke JJ, Leinwand LA, Maier SF, Yin H, Rice KC, Watkins LR. Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun. 2010 Jan; 24(1):83-95.
Score: 0.008
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Hazelbauer GL, Falke JJ, Parkinson JS. Bacterial chemoreceptors: high-performance signaling in networked arrays. Trends Biochem Sci. 2008 Jan; 33(1):9-19.
Score: 0.008
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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