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Leland Shapiro

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone720/723-3099

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kung VM, Ferraz C, Kennis M, Franco-Paredes C, Tuells J, Vargas Barahona L, Shapiro L, Thompson GR, Chastain DB, Henao-Mart?nez AF. Diabetes Mellitus Type 2 as a Risk Factor and Outcome Modifier for Cryptococcosis in HIV Negative, Non-transplant Patients, a Propensity Score Match Analysis. Curr Microbiol. 2023 Oct 31; 80(12):396. PMID: 37907808.
      View in: PubMed
    2. Shapiro L, Scherger S, Franco-Paredes C, Gharamti A, Henao-Martinez AF. Anakinra authorized to treat severe coronavirus disease 2019; Sepsis breakthrough or time to reflect? Front Microbiol. 2023; 14:1250483. PMID: 37928695.
      View in: PubMed
    3. Vargas Barahona L, Molina KC, Pedraza-Ar?valo LC, Sillau S, Tagawa A, Scherger S, Chastain DB, Shapiro L, Tuells J, Franco-Paredes C, Hawkins KL, Maloney JP, Thompson GR, Henao-Mart?nez AF. Previous corticosteroid exposure associates with an increased Pneumocystis jirovecii pneumonia mortality among HIV-negative patients: a global research network with a follow-up multicenter case-control study. Ther Adv Infect Dis. 2023 Jan-Dec; 10:20499361231159481. PMID: 36938147.
      View in: PubMed
    4. Kennis M, Tagawa A, Kung VM, Montalbano G, Narvaez I, Franco-Paredes C, Vargas Barahona L, Madinger N, Shapiro L, Chastain DB, Henao-Mart?nez AF. Seasonal variations and risk factors of Streptococcus pyogenes infection: a multicenter research network study. Ther Adv Infect Dis. 2022 Jan-Dec; 9:20499361221132101. PMID: 36277299.
      View in: PubMed
    5. Shapiro L, Scherger S, Franco-Paredes C, Gharamti AA, Fraulino D, Henao-Martinez AF. Chasing the Ghost: Hyperinflammation Does Not Cause Sepsis. Front Pharmacol. 2022; 13:910516. PMID: 35814227.
      View in: PubMed
    6. Gharamti A, Samara O, Monzon A, Scherger S, DeSanto K, Sillau S, Franco-Paredes C, Henao-Mart?nez A, Shapiro L. Association between cytokine levels, sepsis severity and clinical outcomes in sepsis: a quantitative systematic review protocol. BMJ Open. 2021 08 09; 11(8):e048476. PMID: 34373304.
      View in: PubMed
    7. Gharamti AA, Mundo W, Chastain DB, Franco-Paredes C, Henao-Mart?nez AF, Shapiro L. Pneumocystis jirovecii pneumonia: a proposed novel model of corticosteroid benefit. Ther Adv Infect Dis. 2021 Jan-Dec; 8:20499361211032034. PMID: 34349985.
      View in: PubMed
    8. Archuleta S, Gharamti AA, Sillau S, Castellanos P, Chadalawada S, Mundo W, Bandali M, O?ate J, Mart?nez E, Chastain DB, DeSanto K, Shapiro L, Schwartz IS, Franco-Paredes C, Henao-Mart?nez AF. Increased mortality associated with uncontrolled diabetes mellitus in patients with pulmonary cryptococcosis: a single US cohort study. Ther Adv Infect Dis. 2021 Jan-Dec; 8:20499361211004367. PMID: 33815790.
      View in: PubMed
    9. Gharamti AA, Mei F, Jankousky KC, Huang J, Hyson P, Chastain DB, Fan J, Osae S, Zhang WW, Montoya JG, Erlandson KM, Scherger SJ, Franco-Paredes C, Henao-Mart?nez AF, Shapiro L. Diagnostic Utility of a Ferritin-to-Procalcitonin Ratio to Differentiate Patients With COVID-19 From Those With Bacterial Pneumonia: A Multicenter Study. Open Forum Infect Dis. 2021 Jun; 8(6):ofab124. PMID: 34183978.
      View in: PubMed
    10. Griffin DO, Brennan-Rieder D, Ngo B, Kory P, Confalonieri M, Shapiro L, Iglesias J, Dube M, Nanda N, In GK, Arkfeld D, Chaudhary P, Campese VM, Hanna DL, Sawcer D, Ehresmann G, Peng D, Smorgorzewski M, Amstrong A, Vinjevoll EH, Dasgupta R, Sattler FR, Mussini C, Mitj? O, Soriano V, Peschanski N, Hayem G, Piccirillo MC, Lobo-Ferreira A, Rivero IB, Hung IFH, Rendell M, Ditmore S, Varon J, Marik P. The Importance of Understanding the Stages of COVID-19 in Treatment and Trials. AIDS Rev. 2021 02 08; 23(1):40-47. PMID: 33556957.
      View in: PubMed
    11. Gharamti AA, Mei F, Jankousky KC, Huang J, Hyson P, Chastain DB, Fan J, Osae S, Zhang WW, Montoya JG, Erlandson KM, Scherger SJ, Franco-Paredes C, Henao-Mart?nez AF, Shapiro L. Diagnostic utility of a Ferritin-to-Procalcitonin Ratio to differentiate patients with COVID-19 from those with Bacterial Pneumonia: A multicenter study. medRxiv. 2020 Oct 22. PMID: 33106821.
      View in: PubMed
    12. Mundo W, Morales-Shnaider L, Tewahade S, Wagner E, Archuleta S, Bandali M, Chadalawada S, Johnson SC, Franco-Paredes C, Shapiro L, Henao-Mart?nez AF. Lower Mortality Associated With Adjuvant Corticosteroid Therapy in Non-HIV-Infected Patients With Pneumocystis jirovecii Pneumonia: A Single-Institution Retrospective US Cohort Study. Open Forum Infect Dis. 2020 Sep; 7(9):ofaa354. PMID: 33005696.
      View in: PubMed
    13. Canfield GS, Schultz JS, Windham S, Scherger S, Henao-Martinez AF, Shapiro L, Franco-Paredes C, Chastain DB, Wand T, Krsak M. Empiric Therapies for COVID-19: Destined to Fail by Ignoring the Lessons of History. J Hosp Med. 2020 07 01; 15(7):434-436. PMID: 32584243.
      View in: PubMed
    14. Jankousky KC, Schultz J, Windham S, Henao-Mart?nez AF, Franco-Paredes C, Shapiro L. Preventing SARS-CoV-2 infection by blocking a tissue serine protease. Ther Adv Infect Dis. 2020 Jan-Dec; 7:2049936120933076. PMID: 32577236.
      View in: PubMed
    15. Kashef Hamadani BH, Franco-Paredes C, McCollister B, Shapiro L, Beckham JD, Henao-Mart?nez AF. Cryptococcosis and cryptococcal meningitis: New predictors and clinical outcomes at a United States academic medical centre. Mycoses. 2018 May; 61(5):314-320. PMID: 29284182.
      View in: PubMed
    16. Henao-Mart?nez AF, Gross L, Mcnair B, McCollister B, DeSanto K, Montoya JG, Shapiro L, Beckham JD. Risk Factors for Cryptococcal Meningitis: A Single United States Center Experience. Mycopathologia. 2016 Dec; 181(11-12):807-814. PMID: 27502502.
      View in: PubMed
    17. Zhou X, Liu Z, Shapiro L, Yang J, Burton GF. Low-density lipoprotein receptor-related protein 1 mediates a1-antitrypsin internalization in CD4+ T lymphocytes. J Leukoc Biol. 2015 Dec; 98(6):1027-35. PMID: 26206901.
      View in: PubMed
    18. Yogo N, Shapiro L, Erlandson KM. Sepedonium intra-abdominal infection: a case report and review of an emerging fungal infection. J Antimicrob Chemother. 2014 Sep; 69(9):2583-5. PMID: 24788660.
      View in: PubMed
    19. Gottlieb PA, Alkanani AK, Michels AW, Lewis EC, Shapiro L, Dinarello CA, Zipris D. a1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1? responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes. J Clin Endocrinol Metab. 2014 Aug; 99(8):E1418-26. PMID: 24527714.
      View in: PubMed
    20. Ferreira TC, Sampaio EP, Arga?araz GA, Gondim MV, Shapiro L, Arga?araz ER. Increased prevalence of the alpha-1-antitrypsin (A1AT) deficiency-related S gene in patients infected with human immunodeficiency virus type 1. J Med Virol. 2014 Jan; 86(1):23-9. PMID: 24122823.
      View in: PubMed
    21. Pott GB, Beard KS, Bryan CL, Merrick DT, Shapiro L. Alpha-1 antitrypsin reduces severity of pseudomonas pneumonia in mice and inhibits epithelial barrier disruption and pseudomonas invasion of respiratory epithelial cells. Front Public Health. 2013; 1:19. PMID: 24350188.
      View in: PubMed
    22. Kartalija M, Ovrutsky AR, Bryan CL, Pott GB, Fantuzzi G, Thomas J, Strand MJ, Bai X, Ramamoorthy P, Rothman MS, Nagabhushanam V, McDermott M, Levin AR, Frazer-Abel A, Giclas PC, Korner J, Iseman MD, Shapiro L, Chan ED. Patients with nontuberculous mycobacterial lung disease exhibit unique body and immune phenotypes. Am J Respir Crit Care Med. 2013 Jan 15; 187(2):197-205. PMID: 23144328.
      View in: PubMed
    23. Chan ED, Pott GB, Silkoff PE, Ralston AH, Bryan CL, Shapiro L. Alpha-1-antitrypsin inhibits nitric oxide production. J Leukoc Biol. 2012 Dec; 92(6):1251-60. PMID: 22975343.
      View in: PubMed
    24. Lee JH, Hanaoka M, Kitaguchi Y, Kraskauskas D, Shapiro L, Voelkel NF, Taraseviciene-Stewart L. Imbalance of apoptosis and cell proliferation contributes to the development and persistence of emphysema. Lung. 2012 Feb; 190(1):69-82. PMID: 22015802.
      View in: PubMed
    25. Zhou X, Shapiro L, Fellingham G, Willardson BM, Burton GF. HIV replication in CD4+ T lymphocytes in the presence and absence of follicular dendritic cells: inhibition of replication mediated by a-1-antitrypsin through altered I?Ba ubiquitination. J Immunol. 2011 Mar 01; 186(5):3148-55. PMID: 21263074.
      View in: PubMed
    26. Bryan CL, Beard KS, Pott GB, Rahkola J, Gardner EM, Janoff EN, Shapiro L. HIV infection is associated with reduced serum alpha-1-antitrypsin concentrations. Clin Invest Med. 2010 Dec 01; 33(6):E384-9. PMID: 21134340.
      View in: PubMed
    27. Hiremath J, Thanikachalam S, Parikh K, Shanmugasundaram S, Bangera S, Shapiro L, Pott GB, Vnencak-Jones CL, Arneson C, Wade M, White RJ. Exercise improvement and plasma biomarker changes with intravenous treprostinil therapy for pulmonary arterial hypertension: a placebo-controlled trial. J Heart Lung Transplant. 2010 Feb; 29(2):137-49. PMID: 20022264.
      View in: PubMed
    28. Pott GB, Chan ED, Dinarello CA, Shapiro L. Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood. J Leukoc Biol. 2009 May; 85(5):886-95. PMID: 19197072.
      View in: PubMed
    29. Lewis EC, Mizrahi M, Toledano M, Defelice N, Wright JL, Churg A, Shapiro L, Dinarello CA. alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16236-41. PMID: 18852465.
      View in: PubMed
    30. Pott GB, Sailer CA, Porat R, Peskind RL, Fuchs AC, Angel JB, Skolnik PR, Jacobson MA, Giordano MF, Lebeaut A, Grint PC, Dinarello CA, Shapiro L. Effect of a four-week course of interleukin-10 on cytokine production in a placebo-controlled study of HIV-1-infected subjects. Eur Cytokine Netw. 2007 Jun; 18(2):49-58. PMID: 17594937.
      View in: PubMed
    31. Sailer CA, Pott GB, Dinarello CA, Whinney SM, Forster JE, Larson-Duran JK, Landay A, Al-Harthi L, Schooley RT, Benson CA, Judson FN, Thompson M, Palella FJ, Shapiro L. Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels. J Infect Dis. 2007 Mar 01; 195(5):734-8. PMID: 17262717.
      View in: PubMed
    32. Chan ED, Kaminska AM, Gill W, Chmura K, Feldman NE, Bai X, Floyd CM, Fulton KE, Huitt GA, Strand MJ, Iseman MD, Shapiro L. Alpha-1-antitrypsin (AAT) anomalies are associated with lung disease due to rapidly growing mycobacteria and AAT inhibits Mycobacterium abscessus infection of macrophages. Scand J Infect Dis. 2007; 39(8):690-6. PMID: 17654345.
      View in: PubMed
    33. Lewis EC, Shapiro L, Bowers OJ, Dinarello CA. Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12153-8. PMID: 16093309.
      View in: PubMed
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