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Christopher Jon Phiel

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Denver Campus
DepartmentCLAS-Biology
Phone303/315-7678

    Collapse Research 
    Collapse research activities and funding
    R15GM119103     (PHIEL, CHRISTOPHER J)May 1, 2016 - Jun 30, 2022
    NIH
    The Regulation of mRNA Methylation by Glycogen Synthase Kinase-3
    Role: Principal Investigator
    R01AG031883     (PHIEL, CHRISTOPHER J)Aug 1, 2008 - May 31, 2014
    NIH
    Effects of Conditional GSK3 Knockout on the Pathogenesis of Alzheimers Disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Brandt G, Sedivy LJ, Mitchell M, Phiel CJ. Vitamin C and Transferrin Reduce RNA Methylation in Mouse Embryonic Stem Cells. bioRxiv. 2023 Feb 24. PMID: 36865322.
      View in: PubMed
    2. Sedivy LJ, Brandt G, Martin AL, Abroe HM, Phiel CJ. Mouse Embryonic Stem Cell Pluripotency Factors Regulate RNA Methylation. bioRxiv. 2023 Feb 24. PMID: 36865332.
      View in: PubMed
    3. Jungers CF, Elliff JM, Masson-Meyers DS, Phiel CJ, Origanti S. Regulation of eukaryotic translation initiation factor 6 dynamics through multisite phosphorylation by GSK3. J Biol Chem. 2020 09 04; 295(36):12796-12813. PMID: 32703900.
      View in: PubMed
    4. Asherin RM, Everhart KD, Stophaeros SL, Vogeli JM, Fowler J, Phiel CJ, Kaplan PS. Associations between maternal depression and mother and infant oxytocin receptor gene (OXTR_rs53576) polymorphisms. Dev Psychobiol. 2020 05; 62(4):496-504. PMID: 31755553.
      View in: PubMed
    5. Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, Li H, Sadoshima J. Glycogen Synthase Kinase-3a Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell Metab. 2019 05 07; 29(5):1119-1134.e12. PMID: 30745182.
      View in: PubMed
    6. Fowler JJ, Braley KL, Farero RD, Russell ET, Phiel CJ, Kisley MA, Albeck DS. The late positive potential and subjective arousal ratings evoked by negative images vary as a function of oxytocin receptor genotype SNP rs53576. Neuroreport. 2018 09 26; 29(14):1145-1150. PMID: 29958244.
      View in: PubMed
    7. Bhattacharjee R, Goswami S, Dey S, Gangoda M, Brothag C, Eisa A, Woodgett J, Phiel C, Kline D, Vijayaraghavan S. Isoform-specific requirement for GSK3a in sperm for male fertility. Biol Reprod. 2018 08 01; 99(2):384-394. PMID: 29385396.
      View in: PubMed
    8. Tatavosian R, Duc HN, Huynh TN, Fang D, Schmitt B, Shi X, Deng Y, Phiel C, Yao T, Zhang Z, Wang H, Ren X. Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation. Nat Commun. 2018 05 25; 9(1):2080. PMID: 29802243.
      View in: PubMed
    9. Faulds KJ, Egelston JN, Sedivy LJ, Mitchell MK, Garimella S, Kozlowski H, D'Alessandro A, Hansen KC, Balsbaugh JL, Phiel CJ. Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells. J Biol Chem. 2018 07 06; 293(27):10731-10743. PMID: 29777057.
      View in: PubMed
    10. Gonzalez Malagon SG, Lopez Mu?oz AM, Doro D, Bolger TG, Poon E, Tucker ER, Adel Al-Lami H, Krause M, Phiel CJ, Chesler L, Liu KJ. Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus. Nat Commun. 2018 03 19; 9(1):1126. PMID: 29555900.
      View in: PubMed
    11. Meredith GD, D'Ippolito A, Dudas M, Zeidner LC, Hostetter L, Faulds K, Arnold TH, Popkie AP, Doble BW, Marnellos G, Adams C, Wang Y, Phiel CJ. Glycogen synthase kinase-3 (Gsk-3) plays a fundamental role in maintaining DNA methylation at imprinted loci in mouse embryonic stem cells. Mol Biol Cell. 2015 Jun 01; 26(11):2139-50. PMID: 25833708.
      View in: PubMed
    12. Bhattacharjee R, Goswami S, Dudiki T, Popkie AP, Phiel CJ, Kline D, Vijayaraghavan S. Targeted disruption of glycogen synthase kinase 3A (GSK3A) in mice affects sperm motility resulting in male infertility. Biol Reprod. 2015 Mar; 92(3):65. PMID: 25568307.
      View in: PubMed
    13. Zhen CY, Duc HN, Kokotovic M, Phiel CJ, Ren X. Cbx2 stably associates with mitotic chromosomes via a PRC2- or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes. Mol Biol Cell. 2014 Nov 15; 25(23):3726-39. PMID: 25232004.
      View in: PubMed
    14. Bartman CM, Egelston J, Kattula S, Zeidner LC, D'Ippolito A, Doble BW, Phiel CJ. Gene Expression Profiling in Mouse Embryonic Stem Cells Reveals Glycogen Synthase Kinase-3-Dependent Targets of Phosphatidylinositol 3-Kinase and Wnt/?-Catenin Signaling Pathways. Front Endocrinol (Lausanne). 2014; 5:133. PMID: 25165462.
      View in: PubMed
    15. Bartman CM, Egelston J, Ren X, Das R, Phiel CJ. A simple and efficient method for transfecting mouse embryonic stem cells using polyethylenimine. Exp Cell Res. 2015 Jan 01; 330(1):178-85. PMID: 25102378.
      View in: PubMed
    16. Fleming JL, Phiel CJ, Toland AE. The role for oxidative stress in aberrant DNA methylation in Alzheimer's disease. Curr Alzheimer Res. 2012 Nov; 9(9):1077-96. PMID: 21605062.
      View in: PubMed
    17. Zeidner LC, Buescher JL, Phiel CJ. A novel interaction between Glycogen Synthase Kinase-3a (GSK-3a) and the scaffold protein Receptor for Activated C-Kinase 1 (RACK1) regulates the circadian clock. Int J Biochem Mol Biol. 2011; 2(4):318-27. PMID: 22187666.
      View in: PubMed
    18. He F, Popkie AP, Xiong W, Li L, Wang Y, Phiel CJ, Chen Y. Gsk3? is required in the epithelium for palatal elevation in mice. Dev Dyn. 2010 Dec; 239(12):3235-46. PMID: 20981831.
      View in: PubMed
    19. Popkie AP, Zeidner LC, Albrecht AM, D'Ippolito A, Eckardt S, Newsom DE, Groden J, Doble BW, Aronow B, McLaughlin KJ, White P, Phiel CJ. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J Biol Chem. 2010 Dec 31; 285(53):41337-47. PMID: 21047779.
      View in: PubMed
    20. Yang J, Phiel C. Functions of B56-containing PP2As in major developmental and cancer signaling pathways. Life Sci. 2010 Dec 18; 87(23-26):659-66. PMID: 20934435.
      View in: PubMed
    21. Buescher JL, Phiel CJ. A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity. J Biol Chem. 2010 Mar 12; 285(11):7957-63. PMID: 20080974.
      View in: PubMed
    22. Rorick AM, Mei W, Liette NL, Phiel C, El-Hodiri HM, Yang J. PP2A:B56epsilon is required for eye induction and eye field separation. Dev Biol. 2007 Feb 15; 302(2):477-93. PMID: 17074314.
      View in: PubMed
    23. Checler F, Fr?d?ric C, Alves da Costa C, Cristine Ada C, Ayral E, Erwan A, Andrau D, David A, Dumanchin C, C?cile D, Farzan M, Michael F, Hernandez JF, Jean-Fran?ois H, Martinez J, Lefranc-Jullien S, Solveig LJ, Marambaud P, Philippe M, Pasini A, Andrea P, Petit A, Agn?s P, Phiel C, Christopher P, Robert P, Philippe R, St George-Hyslop P, Peter SG, Wilk S, Sherwin W. JLK inhibitors: isocoumarin compounds as putative probes to selectively target the gamma-secretase pathway. Curr Alzheimer Res. 2005 Jul; 2(3):327-34. PMID: 15974898.
      View in: PubMed
    24. Petit A, Pasini A, Alves Da Costa C, Ayral E, Hernandez JF, Dumanchin-Njock C, Phiel CJ, Marambaud P, Wilk S, Farzan M, Fulcrand P, Martinez J, Andrau D, Checler F. JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. J Neurosci Res. 2003 Nov 01; 74(3):370-7. PMID: 14598313.
      View in: PubMed
    25. Gabetta V, Trzyna W, Phiel C, McHugh KM. Vesicle-associated protein-A is differentially expressed during intestinal smooth muscle cell differentiation. Dev Dyn. 2003 Sep; 228(1):11-20. PMID: 12950075.
      View in: PubMed
    26. Zhang F, Phiel CJ, Spece L, Gurvich N, Klein PS. Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3. J Biol Chem. 2003 Aug 29; 278(35):33067-77. PMID: 12796505.
      View in: PubMed
    27. Phiel CJ, Wilson CA, Lee VM, Klein PS. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature. 2003 May 22; 423(6938):435-9. PMID: 12761548.
      View in: PubMed
    28. Phiel CJ, Gabbeta V, Parsons LM, Rothblat D, Harvey RP, McHugh KM. Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues. J Biol Chem. 2001 Sep 14; 276(37):34637-50. PMID: 11457859.
      View in: PubMed
    29. Phiel CJ, Klein PS. Molecular targets of lithium action. Annu Rev Pharmacol Toxicol. 2001; 41:789-813. PMID: 11264477.
      View in: PubMed
    30. Brittingham J, Phiel C, Trzyna WC, Gabbeta V, McHugh KM. Identification of distinct molecular phenotypes in cultured gastrointestinal smooth muscle cells. Gastroenterology. 1998 Sep; 115(3):605-17. PMID: 9721158.
      View in: PubMed
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