 Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
"Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.
| Descriptor ID |
D020875
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| MeSH Number(s) |
D12.644.400.575.281.075 D12.776.631.650.575.281.075
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| Concept/Terms |
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
- 2-Ala-4-MePhe-5-Gly-Enkephalin
- 2 Ala 4 MePhe 5 Gly Enkephalin
- Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin
- DAGO
- DAMGE
- D-Ala2-NMe-Phe4-Gly-ol Enkephalin
- D Ala2 NMe Phe4 Gly ol Enkephalin
- Enkephalin, D-Ala2-NMe-Phe4-Gly-ol
- DAGOL
- Tyr-Ala-Gly-(NMe)Phe-Gly-ol
- Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-
- D-Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin
- DAMGO
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Below are MeSH descriptors whose meaning is more general than "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-".
Below are MeSH descriptors whose meaning is more specific than "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-".
This graph shows the total number of publications written about "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" by people in this website by year, and whether "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 2 | 2 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" by people in Profiles.
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Sanchez GA, Jutkiewicz EM, Ingram S, Smrcka AV. Coincident Regulation of PLC? Signaling by Gq-Coupled and ?-Opioid Receptors Opposes Opioid-Mediated Antinociception. Mol Pharmacol. 2022 Dec; 102(6):269-279.
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Roncon CM, Yamashita PSM, Frias AT, Audi EA, Graeff FG, Coimbra NC, Zangrossi H. ?-Opioid and 5-HT1A receptors in the dorsomedial hypothalamus interact for the regulation of panic-related defensive responses. J Psychopharmacol. 2017 06; 31(6):715-721.
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Mamaligas AA, Cai Y, Ford CP. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission. Sci Rep. 2016 11 25; 6:37834.
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Bobeck EN, Ingram SL, Hermes SM, Aicher SA, Morgan MM. Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance. Behav Brain Res. 2016 Feb 01; 298(Pt B):17-24.
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Li MH, Suchland KL, Ingram SL. GABAergic transmission and enhanced modulation by opioids and endocannabinoids in adult rat rostral ventromedial medulla. J Physiol. 2015 Jan 01; 593(1):217-30.
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Zwicker JD, Zhang Y, Ren J, Hutchinson MR, Rice KC, Watkins LR, Greer JJ, Funk GD. Glial TLR4 signaling does not contribute to opioid-induced depression of respiration. J Appl Physiol (1985). 2014 Oct 15; 117(8):857-68.
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Lamberts JT, Smith CE, Li MH, Ingram SL, Neubig RR, Traynor JR. Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gao protein. J Neurosci. 2013 Mar 06; 33(10):4369-77.
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Fyfe LW, Cleary DR, Macey TA, Morgan MM, Ingram SL. Tolerance to the antinociceptive effect of morphine in the absence of short-term presynaptic desensitization in rat periaqueductal gray neurons. J Pharmacol Exp Ther. 2010 Dec; 335(3):674-80.
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Arttamangkul S, Quillinan N, Low MJ, von Zastrow M, Pintar J, Williams JT. Differential activation and trafficking of micro-opioid receptors in brain slices. Mol Pharmacol. 2008 Oct; 74(4):972-9.
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Meyer PJ, Fossum EN, Ingram SL, Morgan MM. Analgesic tolerance to microinjection of the micro-opioid agonist DAMGO into the ventrolateral periaqueductal gray. Neuropharmacology. 2007 Jun; 52(8):1580-5.
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