 Amphetamine
"Amphetamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
| Descriptor ID |
D000661
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| MeSH Number(s) |
D02.092.471.683.152.110
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| Concept/Terms |
Amphetamine- Amphetamine
- Amfetamine
- Phenopromin
- Desoxynorephedrin
- Phenamine
l-Amphetamine- l-Amphetamine
- l Amphetamine
- levo-Amphetamine
- levo Amphetamine
- Levoamphetamine
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Below are MeSH descriptors whose meaning is more general than "Amphetamine".
Below are MeSH descriptors whose meaning is more specific than "Amphetamine".
This graph shows the total number of publications written about "Amphetamine" by people in this website by year, and whether "Amphetamine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 1 | 2 | | 1999 | 2 | 0 | 2 | | 2001 | 3 | 0 | 3 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 1 | 2 | | 2005 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2012 | 2 | 1 | 3 | | 2013 | 1 | 2 | 3 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 1 | 2 | | 2016 | 2 | 1 | 3 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Amphetamine" by people in Profiles.
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Rockhill KM, Olson R, Dart RC, Iwanicki JL, Black JC. Differing Behaviors Around Adult Nonmedical Use of Prescription Stimulants and Opioids: Latent Class Analysis. J Med Internet Res. 2023 09 20; 25:e46742.
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Lloyd JT, Yee AG, Kalligappa PK, Jabed A, Cheung PY, Todd KL, Karunasinghe RN, Vlajkovic SM, Freestone PS, Lipski J. Dopamine Dysregulation and Altered Responses to Drugs Affecting Dopaminergic Transmission in a New Dopamine Transporter Knockout (DAT-KO) Rat Model. Neuroscience. 2022 05 21; 491:43-64.
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Black JC, Bau GE, Iwanicki JL, Dart RC. Association of Medical Stimulants With Mortality in the US From 2010 to 2017. JAMA Intern Med. 2021 05 01; 181(5):707-709.
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Underhill SM, Hullihen PD, Chen J, Fenollar-Ferrer C, Rizzo MA, Ingram SL, Amara SG. Amphetamines signal through intracellular TAAR1 receptors coupled to Ga13 and GaS in discrete subcellular domains. Mol Psychiatry. 2021 04; 26(4):1208-1223.
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Bortz DM, Grace AA. Medial septum differentially regulates dopamine neuron activity in the rat ventral tegmental area and substantia nigra via distinct pathways. Neuropsychopharmacology. 2018 09; 43(10):2093-2100.
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Wang X, Gallegos DA, Pogorelov VM, O'Hare JK, Calakos N, Wetsel WC, West AE. Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference. Neuropsychopharmacology. 2018 04; 43(5):953-963.
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Li MH, Underhill SM, Reed C, Phillips TJ, Amara SG, Ingram SL. Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons. Neuropsychopharmacology. 2017 Jun; 42(7):1539-1547.
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Stamenic TT, Poe MM, Rehman S, Santrac A, Divovic B, Scholze P, Ernst M, Cook JM, Savic MM. Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the a5 subunit. Eur J Pharmacol. 2016 Nov 15; 791:433-443.
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Bui QM, Allen LA, Monte AA, Page RL, McIlvennan CK. Amphetamine-positive urine drug screens in the setting of mexiletine use: A case series. J Heart Lung Transplant. 2016 08; 35(8):1045-8.
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Batinic B, Santrac A, Divovic B, Timic T, Stankovic T, Obradovic ALj, Joksimovic S, Savic MM. Lipopolysaccharide exposure during late embryogenesis results in diminished locomotor activity and amphetamine response in females and spatial cognition impairment in males in adult, but not adolescent rat offspring. Behav Brain Res. 2016 Feb 15; 299:72-80.
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