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																		 Rats, Zucker
 
																		 
																		
																	 
																		 
																		
																	 
																			
																					
	"Rats, Zucker" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, 
	MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, 
	which enables searching at various levels of specificity.
 
	
	
		
			
			
				Two populations of Zucker rats have been cited in research--the "fatty" or obese and the lean. The "fatty" rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene.
    
			 
				
				
					
						| Descriptor ID | D011924 |  
						| MeSH Number(s) | B01.050.150.900.649.313.992.635.505.700.550.700 |  
						| Concept/Terms |  |  
				Below are MeSH descriptors whose meaning is more general than "Rats, Zucker". 
				Below are MeSH descriptors whose meaning is more specific than "Rats, Zucker". 
	
	
		
			
			
					
				This graph shows the total number of publications written about "Rats, Zucker" by people in this website by year, and whether "Rats, Zucker" was a major or minor topic of these publications.  
					  To see the data from this visualization as text, click here. 
		            | Year | Major Topic | Minor Topic | Total | 
|---|
 | 1999 | 0 | 1 | 1 |  | 2004 | 0 | 1 | 1 |  | 2005 | 0 | 3 | 3 |  | 2006 | 0 | 4 | 4 |  | 2007 | 0 | 3 | 3 |  | 2008 | 0 | 2 | 2 |  | 2009 | 0 | 1 | 1 |  | 2010 | 0 | 1 | 1 |  | 2011 | 0 | 2 | 2 |  | 2012 | 0 | 1 | 1 |  | 2016 | 0 | 2 | 2 |  | 2017 | 0 | 2 | 2 |  | 2019 | 0 | 1 | 1 |  | 2022 | 0 | 1 | 1 | 
 
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				Below are the most recent publications written about "Rats, Zucker" by people in Profiles. 		
					
								
								Rachubik P, Szrejder M, Rogacka D, Typiak M, Audzeyenka I, Kasztan M, Pollock DM, Angielski S, Piwkowska A. Insulin controls cytoskeleton reorganization and filtration barrier permeability via the PKGIa-Rac1-RhoA crosstalk in cultured rat podocytes. Biochim Biophys Acta Mol Cell Res. 2022 09; 1869(9):119301.
								Rochester E, Wickman BE, Bell A, Simecka C, Clayton ZS, Hakkak R, Hooshmand S. A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model. Food Funct. 2019 Oct 16; 10(10):6851-6857.
								Nam SM, Yoo DY, Kwon HJ, Kim JW, Jung HY, Kim DW, Han HJ, Won MH, Seong JK, Hwang IK, Yoon YS. Proteomic approach to detect changes in hippocampal protein levels in an animal model of type 2 diabetes. Neurochem Int. 2017 Sep; 108:246-253.
								Mason McClatchey P, Wu F, Olfert IM, Ellis CG, Goldman D, Reusch JEB, Frisbee JC. Impaired Tissue Oxygenation in Metabolic Syndrome Requires Increased Microvascular Perfusion Heterogeneity. J Cardiovasc Transl Res. 2017 Feb; 10(1):69-81.
								Nam SM, Kim JW, Yoo DY, Jung HY, Choi JH, Hwang IK, Seong JK, Yoon YS. Reduction of adult hippocampal neurogenesis is amplified by aluminum exposure in a model of type 2 diabetes. J Vet Sci. 2016 Mar; 17(1):13-20.
								Yoo DY, Yim HS, Jung HY, Nam SM, Kim JW, Choi JH, Seong JK, Yoon YS, Kim DW, Hwang IK. Chronic type 2 diabetes reduces the integrity of the blood-brain barrier by reducing tight junction proteins in the hippocampus. J Vet Med Sci. 2016 Jul 01; 78(6):957-62.
								Qin L, Chong T, Rodriguez R, Pugazhenthi S. Glucagon-Like Peptide-1-Mediated Modulation of Inflammatory Pathways in the Diabetic Brain: Relevance to Alzheimer's Disease. Curr Alzheimer Res. 2016; 13(12):1346-1355.
								Koh GY, Derscheid R, Fuller KNZ, Valentine RJ, Leow SE, Reed L, Wisecup E, Schalinske KL, Rowling MJ. Circulating adiponectin concentrations are increased by dietary resistant starch and correlate with serum 25-hydroxycholecalciferol concentrations and kidney function in Zucker diabetic fatty rats. Nutr Res. 2016 Apr; 36(4):311-319.
								Pugazhenthi S, Qin L, Bouchard R. Dipeptidyl peptidase-4 inhibition in diabetic rats leads to activation of the transcription factor CREB in ?-cells. Eur J Pharmacol. 2015 May 15; 755:42-9.
								Tiriveedhi V, Conzen KD, Liaw-Conlin J, Upadhya G, Malone J, Townsend RR, Kerns R, Jia J, Csontos K, Ramachandran S, Mohanakumar T, Anderson CD, Chapman WC. The role of molecular chaperonins in warm ischemia and reperfusion injury in the steatotic liver: a proteomic study. BMC Biochem. 2012 Sep 10; 13:17. | 
																	
																		
																			
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