 Valproic Acid
"Valproic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.
| Descriptor ID |
D014635
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| MeSH Number(s) |
D02.241.081.944.509.900 D10.251.400.895.593.900
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| Concept/Terms |
Valproic Acid- Valproic Acid
- Propylisopropylacetic Acid
- 2-Propylpentanoic Acid
- 2 Propylpentanoic Acid
- Divalproex
Divalproex Sodium- Divalproex Sodium
- Semisodium Valproate
- Valproic Acid, Sodium Salt (2:1)
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Below are MeSH descriptors whose meaning is more general than "Valproic Acid".
Below are MeSH descriptors whose meaning is more specific than "Valproic Acid".
This graph shows the total number of publications written about "Valproic Acid" by people in this website by year, and whether "Valproic Acid" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 2005 | 1 | 2 | 3 | | 2006 | 2 | 2 | 4 | | 2009 | 2 | 0 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 2 | 0 | 2 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 1 | 2 | | 2018 | 1 | 1 | 2 | | 2019 | 1 | 1 | 2 | | 2020 | 1 | 2 | 3 | | 2021 | 0 | 1 | 1 | | 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Valproic Acid" by people in Profiles.
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Beresford T, Ronan PJ, Hipp D, Schmidt B, Thumm EB, Temple B, Wortzel H, Weitzenkamp D, Emrick C, Kelly J, Arciniegas DB. A Double-Blind Placebo-Controlled, Randomized Trial of Divalproex Sodium for Posttraumatic Irritability Greater Than 1 Year After Mild to Moderate Traumatic Brain Injury. J Neuropsychiatry Clin Neurosci. 2022; 34(3):224-232.
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Comstock G, Kilgallon K, Wang GS, Bourne D, Blanchette E, Stenson E. Management and Associated Toxicokinetics of Massive Valproic Acid Ingestion with High Flow Continuous Venovenous Hemodiafiltration. J Med Toxicol. 2022 07; 18(3):239-242.
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Smith EG, Austin KL, Kim HM, Miller DR, Sauer BC, Valenstein M. Suicide death over the first year of lithium versus valproate treatment in cohorts with and without bipolar disorder. J Psychiatr Res. 2022 03; 147:349-356.
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Nickels K, Kossoff EH, Eschbach K, Joshi C. Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort. Epilepsia. 2021 01; 62(1):120-127.
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Cortese S, Novins DK. Editorial: Why JAACAP Published an "Inconclusive" Trial: Optimize, Optimize, Optimize Psychostimulant Treatment. J Am Acad Child Adolesc Psychiatry. 2021 02; 60(2):213-215.
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Chavez A, Quesenberry CP, Darbinian J, Asgari MM. Association of Valproic Acid Use, a Potent Histone Deacetylase Inhibitor, and Melanoma Risk. J Invest Dermatol. 2020 12; 140(12):2353-2358.
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Glatstein M, Bonifacio Rino P, de Pinho S, Scolnik D, Pivko-Levi D, Hoyte C. Levocarnitine for the Treatment of Valproic Acid-Induced Hyperammonemic Encephalopathy in Children: The Experience of a Large, Tertiary Care Pediatric Hospital and a Poison Center. Am J Ther. 2019 May/Jun; 26(3):e344-e349.
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Fontes-Dutra M, Della-Flora Nunes G, Santos-Terra J, Souza-Nunes W, Bauer-Negrini G, Hirsch MM, Green L, Riesgo R, Gottfried C, Bambini-Junior V. Abnormal empathy-like pro-social behaviour in the valproic acid model of autism spectrum disorder. Behav Brain Res. 2019 05 17; 364:11-18.
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Baronio D, Bauer-Negrini G, Castro K, Della-Flora Nunes G, Riesgo R, Mendes-da-Cruz DA, Savino W, Gottfried C, Bambini-Junior V. Reduced CD4 T Lymphocytes in Lymph Nodes of the Mouse Model of Autism Induced by Valproic Acid. Neuroimmunomodulation. 2018; 25(5-6):280-284.
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Hirsch MM, Deckmann I, Fontes-Dutra M, Bauer-Negrini G, Della-Flora Nunes G, Nunes W, Rabelo B, Riesgo R, Margis R, Bambini-Junior V, Gottfried C. Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA. Food Chem Toxicol. 2018 May; 115:336-343.
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