Debrisoquin
"Debrisoquin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Descriptor ID |
D003647
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| MeSH Number(s) |
D03.633.100.531.205
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Debrisoquin".
Below are MeSH descriptors whose meaning is more specific than "Debrisoquin".
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Below are the most recent publications written about "Debrisoquin" by people in Profiles.
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Henthorn TK, Avram MJ, Krejcie TC. Alfentanil clearance is independent of the polymorphic debrisoquin hydroxylase. Anesthesiology. 1989 Nov; 71(5):635-9.
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Bertilsson L, Henthorn TK, Sanz E, Tybring G, S?we J, Vill?n T. Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype. Clin Pharmacol Ther. 1989 Apr; 45(4):348-55.
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Henthorn TK, Benitez J, Avram MJ, Martinez C, Llerena A, Cobaleda J, Krejcie TC, Gibbons RD. Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis. Clin Pharmacol Ther. 1989 Mar; 45(3):328-33.