 Sphingosine
"Sphingosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)
| Descriptor ID |
D013110
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| MeSH Number(s) |
D02.033.100.700 D02.033.455.843 D02.092.063.700
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Sphingosine".
Below are MeSH descriptors whose meaning is more specific than "Sphingosine".
This graph shows the total number of publications written about "Sphingosine" by people in this website by year, and whether "Sphingosine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 1 | 1 | 2 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 1 | 2 | | 2015 | 2 | 2 | 4 | | 2016 | 1 | 2 | 3 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 1 | 2 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 | | 2024 | 2 | 0 | 2 | | 2025 | 2 | 0 | 2 | | 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sphingosine" by people in Profiles.
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Basu SK, Mabry S, Nsiah P, Nicholas SE, Lenchik N, Altawil M, Chiu CY, Stephenson DJ, Chalfant CE, Karamichos D, Mandal N. Sphingolipid Expression During Corneal Wound Healing in a Sphingosine Kinase 1 Knockout Model. Cells. 2026 Apr 21; 15(8).
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Skovsted GF, Aupetit A, Björling K, Haanes KA, Syberg S, Jørgensen NR, Aldana BI, Tsuchimochi H, Waddingham MT, Freude K, Pearson JT, Jensen LJ. Role of S1P- and Rho-kinase signalling in age-related myogenic tone deficiency in murine resistance arteries. Exp Physiol. 2026 Mar; 111(3):1524-1542.
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Iguidbashian J, Zakrzewski J, Lu L, Garcia AM, Khailova L, Deng X, Plenter R, La Rosa FG, Nakano S, Lynch K, Jaggers J, Davidson J, Stone ML. Targeted immunotherapy with sphingosine-1-phosphate improves myocardial contractility and mitochondrial function in a novel murine ex vivo perfusion and transplantation model. J Thorac Cardiovasc Surg. 2025 09; 170(3):764-771.
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Mondal K, Del Mar NA, Gary AA, Grambergs RC, Yousuf M, Tahia F, Stephenson B, Stephenson DJ, Chalfant CE, Reiner A, Mandal N. Sphingolipid changes in mouse brain and plasma after mild traumatic brain injury at the acute phases. Lipids Health Dis. 2024 Jun 27; 23(1):200.
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Danielson SM, Lefferts AR, Norman E, Regner EH, Schulz HM, Sansone-Poe D, Orlicky DJ, Kuhn KA. Myeloid Cells and Sphingosine-1-Phosphate Are Required for TCRaß Intraepithelial Lymphocyte Recruitment to the Colon Epithelium. J Immunol. 2024 Jun 01; 212(11):1843-1854.
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Hay A, Nemkov T, Gamboni F, Dzieciatkowska M, Key A, Galbraith M, Bartsch K, Sun K, Xia Y, Stone M, Busch MP, Norris PJ, Zimring JC, D'Alessandro A. Sphingosine 1-phosphate has a negative effect on RBC storage quality. Blood Adv. 2023 04 25; 7(8):1379-1393.
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Tanaka S, Zheng S, Kharel Y, Fritzemeier RG, Huang T, Foster D, Poudel N, Goggins E, Yamaoka Y, Rudnicka KP, Lipsey JE, Radel HV, Ryuh SM, Inoue T, Yao J, Rosin DL, Schwab SR, Santos WL, Lynch KR, Okusa MD. Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney. Sci Transl Med. 2022 08 17; 14(658):eabj2681.
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Zehra Okus F, Busra Azizoglu Z, Canatan H, Eken A. S1P analogues SEW2871, BAF312 and FTY720 affect human Th17 and Treg generation ex vivo. Int Immunopharmacol. 2022 Jun; 107:108665.
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Karuppuchamy T, Tyler CJ, Lundborg LR, Pérez-Jeldres T, Kimball AK, Clambey ET, Jedlicka P, Rivera-Nieves J. Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn's-Like Ileitis by Suppressing Thymocyte Maturation. Inflamm Bowel Dis. 2020 01 06; 26(2):216-228.
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Ebenezer DL, Berdyshev EV, Bronova IA, Liu Y, Tiruppathi C, Komarova Y, Benevolenskaya EV, Suryadevara V, Ha AW, Harijith A, Tuder RM, Natarajan V, Fu P. Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury. Thorax. 2019 06; 74(6):579-591.
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