 Farnesyltranstransferase
"Farnesyltranstransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the synthesis of geranylgeranyl diphosphate from trans, trans-farnesyl diphosphate and isopentenyl diphosphate.
| Descriptor ID |
D051231
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| MeSH Number(s) |
D08.811.913.225.437
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| Concept/Terms |
Farnesyltranstransferase- Farnesyltranstransferase
- Farnesyltransferase
- Geranylgeranyl Pyrophosphatase
- Pyrophosphatase, Geranylgeranyl
- GGDP Synthase
- Synthase, GGDP
- GGPP Synthase
- Synthase, GGPP
- Farnesyl Diphosphate-Geranylgeranyl Diphosphate Synthase
- Farnesyl Diphosphate Geranylgeranyl Diphosphate Synthase
- Geranylgeranyl-Diphosphate Synthase
- Geranylgeranyl Diphosphate Synthase
- Synthase, Geranylgeranyl-Diphosphate
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Below are MeSH descriptors whose meaning is more general than "Farnesyltranstransferase".
Below are MeSH descriptors whose meaning is more specific than "Farnesyltranstransferase".
This graph shows the total number of publications written about "Farnesyltranstransferase" by people in this website by year, and whether "Farnesyltranstransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 3 | 3 | | 1997 | 0 | 3 | 3 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 3 | 3 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2007 | 3 | 0 | 3 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Farnesyltranstransferase" by people in Profiles.
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Liesveld JL, Rosell KE, Bechelli J, Lu C, Messina P, Mulford D, Ifthikharuddin JJ, Jordan CT, Phillips Ii GL. Proteasome inhibition in myelodysplastic syndromes and acute myelogenous leukemia cell lines. Cancer Invest. 2011 Aug; 29(7):439-50.
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Draznin B. Mitogenic action of insulin: friend, foe or 'frenemy'? Diabetologia. 2010 Feb; 53(2):229-33.
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Chow LQ, Eckhardt SG, O'Bryant CL, Schultz MK, Morrow M, Grolnic S, Basche M, Gore L. A phase I safety, pharmacological, and biological study of the farnesyl protein transferase inhibitor, lonafarnib (SCH 663366), in combination with cisplatin and gemcitabine in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2008 Sep; 62(4):631-46.
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Medeiros BC, Landau HJ, Morrow M, Lockerbie RO, Pitts T, Eckhardt SG. The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines. Leukemia. 2007 Apr; 21(4):739-46.
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Veluthakal R, Kaur H, Goalstone M, Kowluru A. Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells. Diabetes. 2007 Jan; 56(1):204-10.
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Solomon CS, Leitner JW, Goalstone ML. Dominant negative alpha-subunit of farnesyl- and geranylgeranyl-transferase I inhibits insulin-induced differentiation of 3T3-L1 pre-adipocytes. Int J Obes Relat Metab Disord. 2003 Jan; 27(1):40-7.
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Hirsch FR, Franklin WA, Bunn PA. Expression of target molecules in lung cancer: challenge for a new treatment paradigm. Semin Oncol. 2002 Jun; 29(3 Suppl 9):2-8.
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Stephens E, Thureen PJ, Goalstone ML, Anderson MS, Leitner JW, Hay WW, Draznin B. Fetal hyperinsulinemia increases farnesylation of p21 Ras in fetal tissues. Am J Physiol Endocrinol Metab. 2001 Aug; 281(2):E217-23.
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Solomon CS, Goalstone ML. Dominant negative farnesyltransferase alpha-subunit inhibits insulin mitogenic effects. Biochem Biophys Res Commun. 2001 Jul 13; 285(2):161-6.
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Goalstone ML, Leitner JW, Berhanu P, Sharma PM, Olefsky JM, Draznin B. Insulin signals to prenyltransferases via the Shc branch of intracellular signaling. J Biol Chem. 2001 Apr 20; 276(16):12805-12.
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