 Solute Carrier Family 22 Member 5
"Solute Carrier Family 22 Member 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A high-affinity, ATP-binding, co-transporter for CARNITINE that is highly expressed in kidney, skeletal muscle, heart, and placental tissues. It transports one sodium ion with one carnitine molecule. It has a lower affinity for other organic cations and transports them independently of sodium. Mutations in the SLC22A5 gene are associated with systemic carnitine deficiency.
| Descriptor ID |
D000074058
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| MeSH Number(s) |
D12.776.157.530.450.250.812.750 D12.776.157.530.937.612.750 D12.776.543.585.450.250.812.750 D12.776.543.585.937.701.750
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| Concept/Terms |
Solute Carrier Family 22 Member 5- Solute Carrier Family 22 Member 5
- High-Affinity Carnitine Transporter
- Carnitine Transporter, High-Affinity
- High Affinity Carnitine Transporter
- Transporter, High-Affinity Carnitine
- OCTN2 Protein
- Sodium-Dependent Carnitine Cotransporter
- Carnitine Cotransporter, Sodium-Dependent
- Sodium Dependent Carnitine Cotransporter
- Organic Cation-Carnitine Transporter 2
- Organic Cation Carnitine Transporter 2
- SLC22A5 Protein
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Below are MeSH descriptors whose meaning is more general than "Solute Carrier Family 22 Member 5".
Below are MeSH descriptors whose meaning is more specific than "Solute Carrier Family 22 Member 5".
This graph shows the total number of publications written about "Solute Carrier Family 22 Member 5" by people in this website by year, and whether "Solute Carrier Family 22 Member 5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Solute Carrier Family 22 Member 5" by people in Profiles.
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Xu P, Chen C, Zhang Y, Dzieciatkowska M, Brown BC, Zhang W, Xie T, Abdulmalik O, Song A, Tong C, Qi H, Roach R, Kellems RE, D'Alessandro A, Xia Y. Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis. Cell Metab. 2022 02 01; 34(2):299-316.e6.
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Mazzini M, Tadros T, Siwik D, Joseph L, Bristow M, Qin F, Cohen R, Monahan K, Klein M, Colucci W. Primary carnitine deficiency and sudden death: in vivo evidence of myocardial lipid peroxidation and sulfonylation of sarcoendoplasmic reticulum calcium ATPase 2. Cardiology. 2011; 120(1):52-8.
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Amat di San Filippo C, Taylor MR, Mestroni L, Botto LD, Longo N. Cardiomyopathy and carnitine deficiency. Mol Genet Metab. 2008 Jun; 94(2):162-6.
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Enomoto A, Wempe MF, Tsuchida H, Shin HJ, Cha SH, Anzai N, Goto A, Sakamoto A, Niwa T, Kanai Y, Anders MW, Endou H. Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. J Biol Chem. 2002 Sep 27; 277(39):36262-71.
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