 Patched-1 Receptor
"Patched-1 Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A patched receptor for several HEDGEHOG PROTEINS that associates with the SMOOTHENED RECEPTOR to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN; mutations in the patched-1 gene are associated with BASAL CELL NEVUS SYNDROME; SQUAMOUS CELL CARCNIOMA of the ESOPHAGUS; trichoepitheliomas, and CARCINOMA, TRANSITIONAL CELL of the URINARY BLADDER.
| Descriptor ID |
D000072081
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| MeSH Number(s) |
D12.776.543.750.058.500 D12.776.624.776.633.500
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| Concept/Terms |
Patched-1 Receptor- Patched-1 Receptor
- Patched 1 Receptor
- Receptor, Patched-1
- PTCH1 Protein
- Patched Homolog-1
- Patched Homolog 1
- Patched-1 Protein
- Patched 1 Protein
- Patched Receptor-1
- Patched Receptor 1
- Receptor-1, Patched
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Below are MeSH descriptors whose meaning is more general than "Patched-1 Receptor".
Below are MeSH descriptors whose meaning is more specific than "Patched-1 Receptor".
This graph shows the total number of publications written about "Patched-1 Receptor" by people in this website by year, and whether "Patched-1 Receptor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Patched-1 Receptor" by people in Profiles.
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Paudel S, Raina K, Tiku VR, Maurya A, Orlicky DJ, You Z, Rigby CM, Deep G, Kant R, Raina B, Agarwal C, Agarwal R. Chemopreventive efficacy of silibinin against basal cell carcinoma growth and progression in UVB-irradiated Ptch+/- mice. Carcinogenesis. 2022 06 27; 43(6):557-570.
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Rigby C, Deep G, Jain A, Orlicky DJ, Agarwal C, Agarwal R. Silibinin inhibits ultraviolet B radiation-induced mast cells recruitment and bone morphogenetic protein 2 expression in the skin at early stages in Ptch(+/-) mouse model of basal cell carcinoma. Mol Carcinog. 2019 07; 58(7):1260-1271.
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Lorberbaum DS, Ramos AI, Peterson KA, Carpenter BS, Parker DS, De S, Hillers LE, Blake VM, Nishi Y, McFarlane MR, Chiang AC, Kassis JA, Allen BL, McMahon AP, Barolo S. An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1. Elife. 2016 05 05; 5.
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Kurosaka H, Iulianella A, Williams T, Trainor PA. Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis. J Clin Invest. 2014 Apr; 124(4):1660-71.
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Feng W, Choi I, Clouthier DE, Niswander L, Williams T. The Ptch1(DL) mouse: a new model to study lambdoid craniosynostosis and basal cell nevus syndrome-associated skeletal defects. Genesis. 2013 Oct; 51(10):677-89.
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Dennis JF, Kurosaka H, Iulianella A, Pace J, Thomas N, Beckham S, Williams T, Trainor PA. Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects. PLoS Genet. 2012; 8(10):e1002927.
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Jackman WR, Yoo JJ, Stock DW. Hedgehog signaling is required at multiple stages of zebrafish tooth development. BMC Dev Biol. 2010 Nov 30; 10:119.
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Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003 Nov 06; 426(6962):83-7.
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Hall JM, Hooper JE, Finger TE. Expression of sonic hedgehog, patched, and Gli1 in developing taste papillae of the mouse. J Comp Neurol. 1999 Apr 05; 406(2):143-55.
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