 APOBEC-3G Deaminase
"APOBEC-3G Deaminase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An APOBEC deaminase that functions as an inhibitor of RETROVIRIDAE replication and inhibits the mobility of RETROTRANSPOSONS via deaminase-dependent and independent mechanisms. It is selective for SINGLE-STRANDED DNA and does not deaminate double-stranded DNA or single or DOUBLE-STRANDED RNA. It exhibits potent antiviral activity against VIF PROTEIN deficient HIV-1 through the creation of hypermutations in the VIRAL DNA. It also has anti-viral activity against SIMIAN IMMUNODEFICIENCY VIRUSES and HEPATITIS B VIRUS.
| Descriptor ID |
D000071480
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| MeSH Number(s) |
D08.811.277.151.486.250.500.750
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| Concept/Terms |
APOBEC-3G Deaminase- APOBEC-3G Deaminase
- APOBEC 3G Deaminase
- Deaminase, APOBEC-3G
- APOBEC-Related Cytidine Deaminase
- APOBEC Related Cytidine Deaminase
- Cytidine Deaminase, APOBEC-Related
- APOBEC3G Protein
- CEM15 Protein
- APOBEC3G Deaminase
- Deaminase, APOBEC3G
- APOBEC-3G Protein
- APOBEC 3G Protein
- APOBEC-Related Protein
- APOBEC Related Protein
- APOBEC-3G dC-dU Editing Enzyme
- APOBEC 3G dC dU Editing Enzyme
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Below are MeSH descriptors whose meaning is more general than "APOBEC-3G Deaminase".
Below are MeSH descriptors whose meaning is more specific than "APOBEC-3G Deaminase".
This graph shows the total number of publications written about "APOBEC-3G Deaminase" by people in this website by year, and whether "APOBEC-3G Deaminase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2010 | 0 | 2 | 2 | | 2014 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "APOBEC-3G Deaminase" by people in Profiles.
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Lavender KJ, Gibbert K, Peterson KE, Van Dis E, Francois S, Woods T, Messer RJ, Gawanbacht A, M?ller JA, M?nch J, Phillips K, Race B, Harper MS, Guo K, Lee EJ, Trilling M, Hengel H, Piehler J, Verheyen J, Wilson CC, Santiago ML, Hasenkrug KJ, Dittmer U. Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo. J Virol. 2016 07 01; 90(13):6001-6013.
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Wang Y, Kinlock BL, Shao Q, Turner TM, Liu B. HIV-1 Vif inhibits G to A hypermutations catalyzed by virus-encapsidated APOBEC3G to maintain HIV-1 infectivity. Retrovirology. 2014 Oct 11; 11:89.
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Hu C, Saenz DT, Fadel HJ, Walker W, Peretz M, Poeschla EM. The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F. J Virol. 2010 Nov; 84(22):11981-93.
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Sanville B, Dolan MA, Wollenberg K, Yan Y, Martin C, Yeung ML, Strebel K, Buckler-White A, Kozak CA. Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove. PLoS Pathog. 2010 Jul 01; 6:e1000974.
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Sawyer SL, Emerman M, Malik HS. Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G. PLoS Biol. 2004 Sep; 2(9):E275.
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