 Cromakalim
"Cromakalim" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)
| Descriptor ID |
D019806
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| MeSH Number(s) |
D03.383.129.578.150 D03.383.663.283.455 D03.633.100.150.455
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cromakalim".
Below are MeSH descriptors whose meaning is more specific than "Cromakalim".
This graph shows the total number of publications written about "Cromakalim" by people in this website by year, and whether "Cromakalim" was a major or minor topic of these publications.
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Below are the most recent publications written about "Cromakalim" by people in Profiles.
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Bajgar R, Seetharaman S, Kowaltowski AJ, Garlid KD, Paucek P. Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain. J Biol Chem. 2001 Sep 07; 276(36):33369-74.
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Grover GJ, D'Alonzo AJ, Garlid KD, Bajgar R, Lodge NJ, Sleph PG, Darbenzio RB, Hess TA, Smith MA, Paucek P, Atwal KS. Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity. J Pharmacol Exp Ther. 2001 Jun; 297(3):1184-92.
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Garlid KD, Paucek P, Yarov-Yarovoy V, Murray HN, Darbenzio RB, D'Alonzo AJ, Lodge NJ, Smith MA, Grover GJ. Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection. Circ Res. 1997 Dec; 81(6):1072-82.
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Sheridan BC, McIntyre RC, Meldrum DR, Fullerton DA. KATP channels contribute to beta- and adenosine receptor-mediated pulmonary vasorelaxation. Am J Physiol. 1997 11; 273(5):L950-6.
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Paucek P, Yarov-Yarovoy V, Sun X, Garlid KD. Inhibition of the mitochondrial KATP channel by long-chain acyl-CoA esters and activation by guanine nucleotides. J Biol Chem. 1996 Dec 13; 271(50):32084-8.
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Garlid KD, Paucek P, Yarov-Yarovoy V, Sun X, Schindler PA. The mitochondrial KATP channel as a receptor for potassium channel openers. J Biol Chem. 1996 Apr 12; 271(15):8796-9.
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Cornfield DN, McQueston JA, McMurtry IF, Rodman DM, Abman SH. Role of ATP-sensitive potassium channels in ovine fetal pulmonary vascular tone. Am J Physiol. 1992 Nov; 263(5 Pt 2):H1363-8.
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