 Heparin
"Heparin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
| Descriptor ID |
D006493
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| MeSH Number(s) |
D09.698.373.400
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| Concept/Terms |
Heparin- Heparin
- Unfractionated Heparin
- Heparin, Unfractionated
- Heparinic Acid
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Below are MeSH descriptors whose meaning is more general than "Heparin".
Below are MeSH descriptors whose meaning is more specific than "Heparin".
This graph shows the total number of publications written about "Heparin" by people in this website by year, and whether "Heparin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 0 | 2 | | 1996 | 0 | 1 | 1 | | 1997 | 1 | 6 | 7 | | 1998 | 3 | 3 | 6 | | 2000 | 2 | 3 | 5 | | 2001 | 3 | 3 | 6 | | 2002 | 4 | 2 | 6 | | 2003 | 3 | 2 | 5 | | 2004 | 1 | 3 | 4 | | 2005 | 5 | 3 | 8 | | 2006 | 1 | 3 | 4 | | 2007 | 1 | 1 | 2 | | 2008 | 2 | 3 | 5 | | 2009 | 0 | 2 | 2 | | 2010 | 5 | 2 | 7 | | 2011 | 6 | 1 | 7 | | 2012 | 3 | 0 | 3 | | 2013 | 1 | 4 | 5 | | 2014 | 4 | 5 | 9 | | 2015 | 2 | 3 | 5 | | 2016 | 1 | 2 | 3 | | 2017 | 1 | 1 | 2 | | 2018 | 1 | 2 | 3 | | 2019 | 3 | 4 | 7 | | 2020 | 6 | 1 | 7 | | 2021 | 2 | 3 | 5 | | 2022 | 1 | 8 | 9 | | 2023 | 2 | 7 | 9 | | 2024 | 2 | 1 | 3 |
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Below are the most recent publications written about "Heparin" by people in Profiles.
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Credille C, Eason CR, Evans LL, Bothwell S, Gien J, Vaughn AE, Kinsella JP, Varma P, Liechty KW, Derderian SC. Bleeding Complications between Bivalirudin and Heparin for Extracorporeal Membrane Oxygenation in Neonates with Congenital Diaphragmatic Hernia. Fetal Diagn Ther. 2025; 52(2):133-138.
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Giles JB, Martinez KL, Steiner HE, Klein A, Ooi A, Pryor J, Sweitzer N, Fuchs D, Karnes JH. Association of Metal Cations with the Anti-PF4/Heparin Antibody Response in Heparin-Induced Thrombocytopenia. Cardiovasc Toxicol. 2024 Sep; 24(9):968-981.
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Chan ED, King PT, Bai X, Schoffstall AM, Sandhaus RA, Buckle AM. The Inhibition of Serine Proteases by Serpins Is Augmented by Negatively Charged Heparin: A Concise Review of Some Clinically Relevant Interactions. Int J Mol Sci. 2024 Feb 02; 25(3).
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Barrett CD, Moore HB, Moore EE, Chandler J, Sauaia A. Combination of aspirin and rosuvastatin for reduction of venous thromboembolism in severely injured patients: a double-blind, placebo-controlled, pragmatic randomized phase II clinical trial (The STAT Trial). Blood Coagul Fibrinolysis. 2023 Dec 01; 34(8):499-507.
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Vaughn AE, Hall JK, Harrison ML, Klein G, Diaz-Miron J, Yi JA, Acker SN. Practice patterns in the management of pediatric iliofemoral arterial thrombosis. Surgery. 2023 10; 174(4):940-945.
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Giles JB, Rollin J, Martinez KL, Selleng K, Thiele T, Pouplard C, Sheppard JI, Heddle NM, Phillips EJ, Roden DM, Gruel Y, Warkentin TE, Greinacher A, Karnes JH. Laboratory and demographic predictors of functional assay positive status in suspected heparin-induced thrombocytopenia: A multicenter retrospective cohort study. Thromb Res. 2023 09; 229:198-208.
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Hess CN, Hsia J, Carroll IA, Nehler MR, Ruf W, Morrow DA, Nicolau JC, Berwanger O, Szarek M, Capell WH, Johri S, Pursley MS, Gupta R, Meehan PS, Franchi F, Effron MB, Marshall D, Graybill CA, Huebler SP, Keuer T, Bristow MR, Bonaca MP. Novel Tissue Factor Inhibition for Thromboprophylaxis in COVID-19: Primary Results of the ASPEN-COVID-19 Trial. Arterioscler Thromb Vasc Biol. 2023 08; 43(8):1572-1582.
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Bai X, Schountz T, Buckle AM, Talbert JL, Sandhaus RA, Chan ED. Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence. Biochem Soc Trans. 2023 06 28; 51(3):1361-1375.
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Buckley MS, Benanti GE, Gilbert B, Meckel J, Dzierba AL, MacLaren R. Correlation between heparin anti-Xa activity and thromboelastography in adult critically ill COVID-19 patients. Pharmacotherapy. 2023 08; 43(8):795-803.
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Buckley MS, Benanti GE, Meckel J, Tekle LA, Gilbert B, Puebla Neira D, McNierney DA, Korkames G, Yerondopoulos M, Park A, O'Hea JA, MacLaren R. Correlation between partial thromboplastin time and thromboelastography in adult critically ill patients requiring bivalirudin for extracorporeal membrane oxygenation. Pharmacotherapy. 2023 03; 43(3):196-204.
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