 Glutarates
"Glutarates" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Derivatives of glutaric acid (the structural formula (COO-)2C3H6), including its salts and esters.
| Descriptor ID |
D005977
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| MeSH Number(s) |
D02.241.081.337.351
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Glutarates".
Below are MeSH descriptors whose meaning is more specific than "Glutarates".
This graph shows the total number of publications written about "Glutarates" by people in this website by year, and whether "Glutarates" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glutarates" by people in Profiles.
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Houten S, Coughlin CR. Is it time to start to consider treating the liver in glutaric aciduria type 1? J Inherit Metab Dis. 2023 07; 46(4):539-540.
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Goodman SI, Woontner M. An explanation for metabolite excretion in high- and low-excretor patients with glutaric acidemia type 1. Mol Genet Metab. 2019 08; 127(4):325-326.
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Han J, Jackson D, Holm J, Turner K, Ashcraft P, Wang X, Cook B, Arning E, Genta RM, Venuprasad K, Souza RF, Sweetman L, Theiss AL. Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):1057-1062.
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Schillaci LA, Greene CL, Strovel E, Rispoli-Joines J, Spector E, Woontner M, Scharer G, Enns GM, Gallagher R, Zinn AB, McCandless SE, Hoppel CL, Goodman SI, Bedoyan JK. The M405V allele of the glutaryl-CoA dehydrogenase gene is an important marker for glutaric aciduria type I (GA-I) low excretors. Mol Genet Metab. 2016 09; 119(1-2):50-6.
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Li L, Paz AC, Wilky BA, Johnson B, Galoian K, Rosenberg A, Hu G, Tinoco G, Bodamer O, Trent JC. Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells. PLoS One. 2015; 10(9):e0133813.
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Busanello EN, Fernandes CG, Martell RV, Lobato VG, Goodman S, Woontner M, de Souza DO, Wajner M. Disturbance of the glutamatergic system by glutaric acid in striatum and cerebral cortex of glutaryl-CoA dehydrogenase-deficient knockout mice: possible implications for the neuropathology of glutaric acidemia type I. J Neurol Sci. 2014 Nov 15; 346(1-2):260-7.
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Pollyea DA, Kohrt HE, Zhang B, Zehnder J, Schenkein D, Fantin V, Straley K, Vasanthakumar A, Abdel-Wahab O, Levine R, Godley LA, Medeiros BC. 2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels. Leuk Lymphoma. 2013 Feb; 54(2):408-10.
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Al-Dirbashi OY, K?lker S, Ng D, Fisher L, Rupar T, Lepage N, Rashed MS, Santa T, Goodman SI, Geraghty MT, Zschocke J, Christensen E, Hoffmann GF, Chakraborty P. Diagnosis of glutaric aciduria type 1 by measuring 3-hydroxyglutaric acid in dried urine spots by liquid chromatography tandem mass spectrometry. J Inherit Metab Dis. 2011 Feb; 34(1):173-80.
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Crombez EA, Cederbaum SD, Spector E, Chan E, Salazar D, Neidich J, Goodman S. Maternal glutaric acidemia, type I identified by newborn screening. Mol Genet Metab. 2008 May; 94(1):132-4.
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Keyser B, Glatzel M, Stellmer F, Kortmann B, Lukacs Z, K?lker S, Sauer SW, Muschol N, Herdering W, Thiem J, Goodman SI, Koeller DM, Ullrich K, Braulke T, M?hlhausen C. Transport and distribution of 3-hydroxyglutaric acid before and during induced encephalopathic crises in a mouse model of glutaric aciduria type 1. Biochim Biophys Acta. 2008 Jun; 1782(6):385-90.
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