Plicamycin
"Plicamycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
| Descriptor ID |
D008926
|
| MeSH Number(s) |
D02.455.426.559.847.562.050.650 D04.615.562.050.650 D09.408.051.059.650
|
| Concept/Terms |
Plicamycin- Plicamycin
- Mitramycin
- Aureolic Acid
- Acid, Aureolic
- Mithramycin
|
Below are MeSH descriptors whose meaning is more general than "Plicamycin".
Below are MeSH descriptors whose meaning is more specific than "Plicamycin".
This graph shows the total number of publications written about "Plicamycin" by people in this website by year, and whether "Plicamycin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "Plicamycin" by people in Profiles.
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Voisine C, Varma H, Walker N, Bates EA, Stockwell BR, Hart AC. Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans. PLoS One. 2007 Jun 06; 2(6):e504.
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Holmes KW, Hales R, Chu S, Maxwell MJ, Mogayzel PJ, Zeitlin PL. Modulation of Sp1 and Sp3 in lung epithelial cells regulates ClC-2 chloride channel expression. Am J Respir Cell Mol Biol. 2003 Oct; 29(4):499-505.
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Crissman HA, Stevenson AP, Orlicky DJ, Kissane RJ. Detailed studies on the application of three fluorescent antibiotics for DNA staining in flow cytometry. Stain Technol. 1978 Nov; 53(6):321-30.