 Glucose-6-Phosphate Isomerase
"Glucose-6-Phosphate Isomerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
| Descriptor ID |
D005956
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| MeSH Number(s) |
D08.811.399.475.200.350
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| Concept/Terms |
Glucose-6-Phosphate Isomerase- Glucose-6-Phosphate Isomerase
- Glucose 6 Phosphate Isomerase
- Isomerase, Glucose-6-Phosphate
- Isomerase, Glucose 6 Phosphate
- Phosphohexose Isomerase
- Isomerase, Phosphohexose
- Glucosephosphate Isomerase
- Isomerase, Glucosephosphate
- Phosphoglucose Isomerase
- Isomerase, Phosphoglucose
Autocrine Motility Factor- Autocrine Motility Factor
- Motility Factor, Autocrine
- Tumor Autocrine Motility Factor
- Tumor-Cell Autocrine Motility Factor
- Tumor Cell Autocrine Motility Factor
- Neuroleukin
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This graph shows the total number of publications written about "Glucose-6-Phosphate Isomerase" by people in this website by year, and whether "Glucose-6-Phosphate Isomerase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1997 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Glucose-6-Phosphate Isomerase" by people in Profiles.
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Wheat CW, Watt WB, Pollock DD, Schulte PM. From DNA to fitness differences: sequences and structures of adaptive variants of Colias phosphoglucose isomerase (PGI). Mol Biol Evol. 2006 Mar; 23(3):499-512.
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Fox MA, Colello RJ, Macklin WB, Fuss B. Phosphodiesterase-Ialpha/autotaxin: a counteradhesive protein expressed by oligodendrocytes during onset of myelination. Mol Cell Neurosci. 2003 Jul; 23(3):507-19.
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Beutler E, West C, Britton HA, Harris J, Forman L. Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA). Blood Cells Mol Dis. 1997 Dec; 23(3):402-9.
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