 Clioquinol
"Clioquinol" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
| Descriptor ID |
D007464
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| MeSH Number(s) |
D03.633.100.810.350.625.400
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| Concept/Terms |
Clioquinol- Clioquinol
- 5-Chloro-7-iodo-8-quinolinol
- 5 Chloro 7 iodo 8 quinolinol
- Iodochloroxyquinoline
- Chloroiodoquine
- Iodochlorhydroxyquin
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Below are MeSH descriptors whose meaning is more general than "Clioquinol".
Below are MeSH descriptors whose meaning is more specific than "Clioquinol".
This graph shows the total number of publications written about "Clioquinol" by people in this website by year, and whether "Clioquinol" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 1 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Clioquinol" by people in Profiles.
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McColl G, Roberts BR, Pukala TL, Kenche VB, Roberts CM, Link CD, Ryan TM, Masters CL, Barnham KJ, Bush AI, Cherny RA. Utility of an improved model of amyloid-beta (A?1?42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease. Mol Neurodegener. 2012 Nov 21; 7:57.
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Jiang H, Taggart JE, Zhang X, Benbrook DM, Lind SE, Ding WQ. Nitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline). Cancer Lett. 2011 Dec 15; 312(1):11-7.
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Ding WQ, Lind SE. Metal ionophores - an emerging class of anticancer drugs. IUBMB Life. 2009 Nov; 61(11):1013-8.
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Yu H, Zhou Y, Lind SE, Ding WQ. Clioquinol targets zinc to lysosomes in human cancer cells. Biochem J. 2009 Jan 01; 417(1):133-9.
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Ding WQ, Yu HJ, Lind SE. Zinc-binding compounds induce cancer cell death via distinct modes of action. Cancer Lett. 2008 Nov 28; 271(2):251-9.
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Ding WQ, Liu B, Vaught JL, Palmiter RD, Lind SE. Clioquinol and docosahexaenoic acid act synergistically to kill tumor cells. Mol Cancer Ther. 2006 Jul; 5(7):1864-72.
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Ding WQ, Liu B, Vaught JL, Yamauchi H, Lind SE. Anticancer activity of the antibiotic clioquinol. Cancer Res. 2005 Apr 15; 65(8):3389-95.
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Kantner A. [The treatment of eczema in children with flumethasone privalate and vioform]. Dermatol Wochenschr. 1968 Apr 20; 154(16):361-4.
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Kantner A. [Advantages of modern antimycotic therapy]. Dermatol Wochenschr. 1967 Jul 15; 153(28):779-82.
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