 Trinucleotide Repeat Expansion
"Trinucleotide Repeat Expansion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.
| Descriptor ID |
D019680
|
| MeSH Number(s) |
G02.111.570.080.708.800.140.865 G02.111.570.080.708.800.500.850.200 G05.360.080.708.800.074.865 G05.360.080.708.800.500.850.200 G05.360.340.024.189.220.865 G05.360.340.024.850.500.850.200 G05.365.590.220.865 G05.558.220.865
|
| Concept/Terms |
Trinucleotide Repeat Expansion- Trinucleotide Repeat Expansion
- Expansion, Trinucleotide Repeat
- Expansions, Trinucleotide Repeat
- Repeat Expansion, Trinucleotide
- Repeat Expansions, Trinucleotide
- Trinucleotide Repeat Expansions
- Expanded Trinucleotide Repeat
- Expanded Trinucleotide Repeats
- Repeat, Expanded Trinucleotide
- Repeats, Expanded Trinucleotide
- Trinucleotide Repeat, Expanded
- Trinucleotide Repeats, Expanded
|
Below are MeSH descriptors whose meaning is more general than "Trinucleotide Repeat Expansion".
Below are MeSH descriptors whose meaning is more specific than "Trinucleotide Repeat Expansion".
This graph shows the total number of publications written about "Trinucleotide Repeat Expansion" by people in this website by year, and whether "Trinucleotide Repeat Expansion" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2007 | 0 | 2 | 2 | | 2008 | 1 | 2 | 3 | | 2009 | 1 | 1 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 2 | 3 | | 2014 | 0 | 1 | 1 | | 2015 | 2 | 0 | 2 | | 2016 | 2 | 0 | 2 | | 2017 | 1 | 1 | 2 | | 2019 | 0 | 1 | 1 | | 2023 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Trinucleotide Repeat Expansion" by people in Profiles.
-
Dias CM, Issac B, Sun L, Lukowicz A, Talukdar M, Akula SK, Miller MB, Walsh K, Rockowitz S, Walsh CA. Glial dysregulation in the human brain in fragile X-associated tremor/ataxia syndrome. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2300052120.
-
Rodden LN, Rummey C, Kessler S, Wilson RB, Lynch DR. A Novel Metric for Predicting Severity of Disease Features in Friedreich's Ataxia. Mov Disord. 2023 06; 38(6):970-977.
-
Heft IE, Mostovoy Y, Levy-Sakin M, Ma W, Stevens AJ, Pastor S, McCaffrey J, Boffelli D, Martin DI, Xiao M, Kennedy MA, Kwok PY, Sikela JM. The Driver of Extreme Human-Specific Olduvai Repeat Expansion Remains Highly Active in the Human Genome. Genetics. 2020 01; 214(1):179-191.
-
Marty B, Naeije G, Bourguignon M, Wens V, Jousm?ki V, Lynch DR, Gaetz W, Goldman S, Hari R, Pandolfo M, De Ti?ge X. Evidence for genetically determined degeneration of proprioceptive tracts in Friedreich ataxia. Neurology. 2019 07 09; 93(2):e116-e124.
-
Shickman R, Famula J, Tassone F, Leehey M, Ferrer E, Rivera SM, Hessl D. Age- and CGG repeat-related slowing of manual movement in fragile X carriers: A prodrome of fragile X-associated tremor ataxia syndrome? Mov Disord. 2018 04; 33(4):628-636.
-
Long A, Napierala JS, Polak U, Hauser L, Koeppen AH, Lynch DR, Napierala M. Somatic instability of the expanded GAA repeats in Friedreich's ataxia. PLoS One. 2017; 12(12):e0189990.
-
Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Nagpal A, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, McCullagh EA, Gamache K, Nader K, Lacaille JC, Gkogkas CG, Sonenberg N. Metformin ameliorates core deficits in a mouse model of fragile X syndrome. Nat Med. 2017 Jun; 23(6):674-677.
-
McCormick A, Shinnick J, Schadt K, Rodriguez R, Addonizio L, Hirano M, Perlman S, Lin KY, Lynch DR. Cardiac transplantation in Friedreich Ataxia: Extended follow-up. J Neurol Sci. 2017 Apr 15; 375:471-473.
-
Debrey SM, Leehey MA, Klepitskaya O, Filley CM, Shah RC, Kluger B, Berry-Kravis E, Spector E, Tassone F, Hall DA. Clinical Phenotype of Adult Fragile X Gray Zone Allele Carriers: a Case Series. Cerebellum. 2016 10; 15(5):623-31.
-
Isaacs CJ, Brigatti KW, Kucheruk O, Ratcliffe S, Sciascia T, McCormack SE, Willi SM, Lynch DR. Effects of genetic severity on glucose homeostasis in Friedreich ataxia. Muscle Nerve. 2016 11; 54(5):887-894.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|