 beta-Lactams
"beta-Lactams" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
| Descriptor ID |
D047090
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| MeSH Number(s) |
D02.065.589.099 D02.886.108 D03.633.100.300
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "beta-Lactams".
Below are MeSH descriptors whose meaning is more specific than "beta-Lactams".
This graph shows the total number of publications written about "beta-Lactams" by people in this website by year, and whether "beta-Lactams" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2012 | 3 | 1 | 4 | | 2013 | 0 | 2 | 2 | | 2015 | 3 | 1 | 4 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 1 | 2 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 2 | 3 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 | | 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "beta-Lactams" by people in Profiles.
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Alosaimy S, Lagnf AM, Hobbs ALV, Mubarez M, Kufel WD, Morrisette T, Polisetty RS, Li D, Veve MP, Simon SP, Truong J, Finch N, Venugopalan V, Rico M, Amaya L, Yost C, Cubillos A, Chandler E, Patch M, Smith IMK, Biagi M, Wrin J, Moore WJ, Molina KC, Rebold N, Holger D, Kunz Coyne AJ, Jorgensen SCJ, Witucki P, Tran NN, Davis SL, Sakoulas G, Rybak MJ. Nephrotoxicity of Vancomycin in Combination With Beta-Lactam Agents: Ceftolozane-Tazobactam vs Piperacillin-Tazobactam. Clin Infect Dis. 2023 02 08; 76(3):e1444-e1455.
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Hahn A, Burrell A, Chaney H, Sami I, Koumbourlis AC, Freishtat RJ, Crandall KA, Zemanick ET. Therapeutic beta-lactam dosages and broad-spectrum antibiotics are associated with reductions in microbial richness and diversity in persons with cystic fibrosis. Sci Rep. 2023 01 21; 13(1):1217.
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Dousa KM, Nguyen DC, Kurz SG, Taracila MA, Bethel CR, Schinabeck W, Kreiswirth BN, Brown ST, Boom WH, Hotchkiss RS, Remy KE, Jacono FJ, Daley CL, Holland SM, Miller AA, Bonomo RA. Inhibiting Mycobacterium abscessus Cell Wall Synthesis: Using a Novel Diazabicyclooctane ?-Lactamase Inhibitor To Augment ?-Lactam Action. mBio. 2022 02 22; 13(1):e0352921.
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Hahn A, Burrell A, Chaney H, Sami I, Koumbourlis AC, Freishtat RJ, Zemanick ET, Louie S, Crandall KA. Importance of beta-lactam pharmacokinetics and pharmacodynamics on the recovery of microbial diversity in the airway of persons with cystic fibrosis. J Investig Med. 2021 10; 69(7):1350-1359.
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Molina KC, Morrisette T, Miller MA, Huang V, Fish DN. The Emerging Role of ?-Lactams in the Treatment of Methicillin-Resistant Staphylococcus aureus Bloodstream Infections. Antimicrob Agents Chemother. 2020 06 23; 64(7).
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Shaker M, McWilliams S, Greenhawt M. Update on penicillin allergy delabeling. Curr Opin Pediatr. 2020 04; 32(2):321-327.
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Dhawan S, Awolade P, Kisten P, Cele N, Pillay AS, Saha S, Kaur M, Jonnalagadda SB, Singh P. Synthesis, Cytotoxicity and Antimicrobial Evaluation of New Coumarin-Tagged ?-Lactam Triazole Hybrid. Chem Biodivers. 2020 Jan; 17(1):e1900462.
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Hahn A, Fanous H, Jensen C, Chaney H, Sami I, Perez GF, Koumbourlis AC, Louie S, Bost JE, van den Anker JN, Freishtat RJ, Zemanick ET, Crandall KA. Changes in microbiome diversity following beta-lactam antibiotic treatment are associated with therapeutic versus subtherapeutic antibiotic exposure in cystic fibrosis. Sci Rep. 2019 02 22; 9(1):2534.
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Wlodarchak N, Teachout N, Beczkiewicz J, Procknow R, Schaenzer AJ, Satyshur K, Pavelka M, Zuercher W, Drewry D, Sauer JD, Striker R. In Silico Screen and Structural Analysis Identifies Bacterial Kinase Inhibitors which Act with ?-Lactams To Inhibit Mycobacterial Growth. Mol Pharm. 2018 11 05; 15(11):5410-5426.
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Jeffres MN, Hall-Lipsy EA, King ST, Cleary JD. Systematic review of professional liability when prescribing ?-lactams for patients with a known penicillin allergy. Ann Allergy Asthma Immunol. 2018 11; 121(5):530-536.
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