 Gene Products, nef
"Gene Products, nef" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.
| Descriptor ID |
D015693
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| MeSH Number(s) |
D12.776.964.775.362 D12.776.964.925.500
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| Concept/Terms |
Gene Products, nef- Gene Products, nef
- Gene Product, nef
- nef Gene Product
- nef Protein
- 3'-orf Protein
- 3' orf Protein
- nef Gene Products
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Below are MeSH descriptors whose meaning is more general than "Gene Products, nef".
Below are MeSH descriptors whose meaning is more specific than "Gene Products, nef".
This graph shows the total number of publications written about "Gene Products, nef" by people in this website by year, and whether "Gene Products, nef" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2006 | 2 | 0 | 2 | | 2007 | 0 | 1 | 1 | | 2009 | 2 | 0 | 2 |
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Below are the most recent publications written about "Gene Products, nef" by people in Profiles.
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Sharma D, Bastard K, Guethlein LA, Norman PJ, Yawata N, Yawata M, Pando M, Thananchai H, Dong T, Rowland-Jones S, Brodsky FM, Parham P. Dimorphic motifs in D0 and D1+D2 domains of killer cell Ig-like receptor 3DL1 combine to form receptors with high, moderate, and no avidity for the complex of a peptide derived from HIV and HLA-A*2402. J Immunol. 2009 Oct 01; 183(7):4569-82.
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Sehgal PB, Mukhopadhyay S, Patel K, Xu F, Almod?var S, Tuder RM, Flores SC. Golgi dysfunction is a common feature in idiopathic human pulmonary hypertension and vascular lesions in SHIV-nef-infected macaques. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L729-37.
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Tuder RM, Marecki JC, Richter A, Fijalkowska I, Flores S. Pathology of pulmonary hypertension. Clin Chest Med. 2007 Mar; 28(1):23-42, vii.
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Schindler M, M?nch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, M?ller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Silvestri G, Sharp PM, Hahn BH, Kirchhoff F. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell. 2006 Jun 16; 125(6):1055-67.
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Marecki JC, Cool CD, Parr JE, Beckey VE, Luciw PA, Tarantal AF, Carville A, Shannon RP, Cota-Gomez A, Tuder RM, Voelkel NF, Flores SC. HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques. Am J Respir Crit Care Med. 2006 Aug 15; 174(4):437-45.
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Kirchhoff F, Schindler M, Bailer N, Renkema GH, Saksela K, Knoop V, M?ller-Trutwin MC, Santiago ML, Bibollet-Ruche F, Dittmar MT, Heeney JL, Hahn BH, M?nch J. Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors. J Virol. 2004 Jul; 78(13):6864-74.
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Friedman RS, Frankel FR, Xu Z, Lieberman J. Induction of human immunodeficiency virus (HIV)-specific CD8 T-cell responses by Listeria monocytogenes and a hyperattenuated Listeria strain engineered to express HIV antigens. J Virol. 2000 Nov; 74(21):9987-93.
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Swingler S, Mann A, Jacqu? J, Brichacek B, Sasseville VG, Williams K, Lackner AA, Janoff EN, Wang R, Fisher D, Stevenson M. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Nat Med. 1999 Sep; 5(9):997-103.
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