 Apolipoprotein A-II
"Apolipoprotein A-II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The second most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. It has a high lipid affinity and is known to displace APOLIPOPROTEIN A-I from HDL particles and generates a stable HDL complex. ApoA-II can modulate the activation of LECITHIN CHOLESTEROL ACYLTRANSFERASE in the presence of APOLIPOPROTEIN A-I, thus affecting HDL metabolism.
| Descriptor ID |
D016633
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| MeSH Number(s) |
D10.532.091.200.150 D12.776.070.400.200.150 D12.776.521.120.200.150
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| Concept/Terms |
Apolipoprotein A-II- Apolipoprotein A-II
- Apolipoprotein A II
- Apo A-II
- Apo A2
- Apo AII
- ApoA-II
- Apolipoprotein A-2
- Apolipoprotein A 2
- Apolipoprotein A2
- Apolipoprotein AII
- Apo A-2
- ApoA-2
Pro-Apolipoprotein A-II- Pro-Apolipoprotein A-II
- Pro Apolipoprotein A II
- Proapolipoprotein A-II
- Proapolipoprotein A II
- Pro-Apo A-II
- Pro Apo A II
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Below are MeSH descriptors whose meaning is more general than "Apolipoprotein A-II".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein A-II".
This graph shows the total number of publications written about "Apolipoprotein A-II" by people in this website by year, and whether "Apolipoprotein A-II" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apolipoprotein A-II" by people in Profiles.
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Sarkar S, Morris J, You Y, Sexmith H, Street SE, Thibert SM, Attah IK, Hutchinson Bunch CM, Novikova IV, Evans JE, Shah AS, Gordon SM, Segrest JP, Bornfeldt KE, Vaisar T, Heinecke JW, Davidson WS, Melchior JT. APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1. J Lipid Res. 2024 12; 65(12):100686.
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Melchior JT, Street SE, Vaisar T, Hart R, Jerome J, Kuklenyik Z, Clouet-Foraison N, Thornock C, Bedi S, Shah AS, Segrest JP, Heinecke JW, Davidson WS. Apolipoprotein A-I modulates HDL particle size in the absence of apolipoprotein A-II. J Lipid Res. 2021; 62:100099.
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Melchior JT, Street SE, Andraski AB, Furtado JD, Sacks FM, Shute RL, Greve EI, Swertfeger DK, Li H, Shah AS, Lu LJ, Davidson WS. Apolipoprotein A-II alters the proteome of human lipoproteins and enhances cholesterol efflux from ABCA1. J Lipid Res. 2017 07; 58(7):1374-1385.
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Gordon SM, Li H, Zhu X, Tso P, Reardon CA, Shah AS, Lu LJ, Davidson WS. Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome. J Proteomics. 2016 09 02; 146:184-94.
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Gordon JI, Sims HF, Edelstein C, Scanu AM, Strauss AW. Extracellular processing of proapolipoprotein A-II in Hep G2 cell cultures is mediated by a 54-kDa protease immunologically related to cathepsin B. J Biol Chem. 1985 Nov 25; 260(27):14824-31.
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Eckel RH, Albers JJ, Cheung MC, Wahl PW, Lindgren FT, Bierman EL. High density lipoprotein composition in insulin-dependent diabetes mellitus. Diabetes. 1981 Feb; 30(2):132-8.
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