 Pilocarpine
"Pilocarpine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
| Descriptor ID |
D010862
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| MeSH Number(s) |
D03.132.672
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| Concept/Terms |
Pilocarpine Nitrate- Pilocarpine Nitrate
- Nitrate, Pilocarpine
- Pilocarpine Mononitrate, (3S-cis)-Isomer
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Below are MeSH descriptors whose meaning is more general than "Pilocarpine".
Below are MeSH descriptors whose meaning is more specific than "Pilocarpine".
This graph shows the total number of publications written about "Pilocarpine" by people in this website by year, and whether "Pilocarpine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2024 | 0 | 1 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pilocarpine" by people in Profiles.
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Xia JL, Zaver D, Kim EJ, Patnaik JL, Ertel MK, Capitena CE, SooHoo JR, Kahook MY, Pantcheva MB, Seibold LK. Postoperative Use of Pilocarpine After Kahook Dual Blade Goniotomy in Mild to End-Stage Glaucoma. Curr Eye Res. 2025 May; 50(5):490-495.
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Carrel A, Napoli E, Hixson K, Carlsen J, Cruz Del Angel Y, Strode D, Busquet N, Kumar V, Wempe MF, Russek SJ, Brooks-Kayal AR. Ruxolitinib-dependent reduction of seizure load and duration is accompanied by spatial memory improvement in the rat pilocarpine model of temporal lobe epilepsy. Neurotherapeutics. 2025 Mar; 22(2):e00506.
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Gonz?lez MI. Calpain-dependent cleavage of GABAergic proteins during epileptogenesis. Epilepsy Res. 2019 11; 157:106206.
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Seibold LK, Wagner BD, Lynch AM, Kahook MY. The Diurnal and Nocturnal Effects of Pilocarpine on Intraocular Pressure in Patients Receiving Prostaglandin Analog Monotherapy. J Ocul Pharmacol Ther. 2018 10; 34(8):590-595.
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Smith ZZ, Benison AM, Bercum FM, Dudek FE, Barth DS. Progression of convulsive and nonconvulsive seizures during epileptogenesis after pilocarpine-induced status epilepticus. J Neurophysiol. 2018 05 01; 119(5):1818-1835.
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Pearson-Smith JN, Liang LP, Rowley SD, Day BJ, Patel M. Oxidative Stress Contributes to Status Epilepticus Associated Mortality. Neurochem Res. 2017 Jul; 42(7):2024-2032.
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Lam PM, Carlsen J, Gonz?lez MI. A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy. Neurobiol Dis. 2017 Jun; 102:1-10.
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Thomas AX, Cruz Del Angel Y, Gonzalez MI, Carrel AJ, Carlsen J, Lam PM, Hempstead BL, Russek SJ, Brooks-Kayal AR. Rapid Increases in proBDNF after Pilocarpine-Induced Status Epilepticus in Mice Are Associated with Reduced proBDNF Cleavage Machinery. eNeuro. 2016 Jan-Feb; 3(1).
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Pearson JN, Rowley S, Liang LP, White AM, Day BJ, Patel M. Reactive oxygen species mediate cognitive deficits in experimental temporal lobe epilepsy. Neurobiol Dis. 2015 Oct; 82:289-297.
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Gonz?lez MI, Grabenstatter HL, Cea-Del Rio CA, Cruz Del Angel Y, Carlsen J, Laoprasert RP, White AM, Huntsman MM, Brooks-Kayal A. Seizure-related regulation of GABAA receptors in spontaneously epileptic rats. Neurobiol Dis. 2015 May; 77:246-56.
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