 Ribonucleoside Diphosphate Reductase
"Ribonucleoside Diphosphate Reductase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the oxidoreductase class that catalyzes the formation of 2'-deoxyribonucleotides from the corresponding ribonucleotides using NADPH as the ultimate electron donor. The deoxyribonucleoside diphosphates are used in DNA synthesis. (From Dorland, 27th ed) EC 1.17.4.1.
| Descriptor ID |
D012262
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| MeSH Number(s) |
D08.811.682.810.567
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Ribonucleoside Diphosphate Reductase".
Below are MeSH descriptors whose meaning is more specific than "Ribonucleoside Diphosphate Reductase".
This graph shows the total number of publications written about "Ribonucleoside Diphosphate Reductase" by people in this website by year, and whether "Ribonucleoside Diphosphate Reductase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ribonucleoside Diphosphate Reductase" by people in Profiles.
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Bokhari AA, Lai WY, Le AT, Gabre JL, Chuang TP, Fransson S, Bergman B, Djos A, Chen N, Martinsson T, Van den Eynden J, Doebele RC, Palmer RH, Hallberg B, Umapathy G. Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in NSCLC. Lung Cancer. 2022 09; 171:103-114.
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Ripin N, Boudet J, Duszczyk MM, Hinniger A, Faller M, Krepl M, Gadi A, Schneider RJ, ?poner J, Meisner-Kober NC, Allain FH. Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):2935-2944.
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Wu X, An X, Zhang C, Huang M. Clb6-Cdc28 Promotes Ribonucleotide Reductase Subcellular Redistribution during S Phase. Mol Cell Biol. 2018 03 15; 38(6).
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Sanvisens N, Romero AM, Zhang C, Wu X, An X, Huang M, Puig S. Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Small Subunit Localization in Response to Iron Deficiency. J Biol Chem. 2016 Apr 29; 291(18):9807-17.
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Zhang Y, Li H, Zhang C, An X, Liu L, Stubbe J, Huang M. Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):E1695-704.
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Aird KM, Zhang G, Li H, Tu Z, Bitler BG, Garipov A, Wu H, Wei Z, Wagner SN, Herlyn M, Zhang R. Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. Cell Rep. 2013 Apr 25; 3(4):1252-65.
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Sanvisens N, Ba?? MC, Huang M, Puig S. Regulation of ribonucleotide reductase in response to iron deficiency. Mol Cell. 2011 Dec 09; 44(5):759-69.
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Giovannetti E, Del Tacca M, Mey V, Funel N, Nannizzi S, Ricci S, Orlandini C, Boggi U, Campani D, Del Chiaro M, Iannopollo M, Bevilacqua G, Mosca F, Danesi R. Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine. Cancer Res. 2006 Apr 01; 66(7):3928-35.
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Evans TC, Benner J, Xu MQ. The in vitro ligation of bacterially expressed proteins using an intein from Methanobacterium thermoautotrophicum. J Biol Chem. 1999 Feb 12; 274(7):3923-6.
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