 Frontotemporal Lobar Degeneration
"Frontotemporal Lobar Degeneration" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.
| Descriptor ID |
D057174
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| MeSH Number(s) |
C10.228.140.380.266 C10.574.950.300 C18.452.845.800.300 F03.615.400.380
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| Concept/Terms |
Frontotemporal Lobar Degeneration- Frontotemporal Lobar Degeneration
- Degeneration, Frontotemporal Lobar
- Degenerations, Frontotemporal Lobar
- Frontotemporal Lobar Degenerations
- Lobar Degeneration, Frontotemporal
- Lobar Degenerations, Frontotemporal
- FTLD
- FTLDs
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Below are MeSH descriptors whose meaning is more general than "Frontotemporal Lobar Degeneration".
Below are MeSH descriptors whose meaning is more specific than "Frontotemporal Lobar Degeneration".
This graph shows the total number of publications written about "Frontotemporal Lobar Degeneration" by people in this website by year, and whether "Frontotemporal Lobar Degeneration" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 | | 2013 | 2 | 0 | 2 | | 2015 | 1 | 0 | 1 | | 2017 | 1 | 1 | 2 | | 2018 | 1 | 1 | 2 | | 2022 | 1 | 0 | 1 | | 2023 | 2 | 0 | 2 | | 2024 | 2 | 0 | 2 | | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Frontotemporal Lobar Degeneration" by people in Profiles.
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Saloner R, Staffaroni AM, Dammer EB, Johnson ECB, Paolillo EW, Wise A, Heuer HW, Forsberg LK, Lario-Lago A, Webb JD, Vogel JW, Santillo AF, Hansson O, Kramer JH, Miller BL, Li J, Loureiro J, Sivasankaran R, Worringer KA, Seyfried NT, Yokoyama JS, Spina S, Grinberg LT, Seeley WW, VandeVrede L, Ljubenkov PA, Bayram E, Bozoki A, Brushaber D, Considine CM, Day GS, Dickerson BC, Domoto-Reilly K, Faber K, Galasko DR, Gendron T, Geschwind DH, Ghoshal N, Graff-Radford N, Hales CM, Honig LS, Hsiung GR, Huey ED, Kornak J, Kremers W, Lapid MI, Lee SE, Litvan I, McMillan CT, Mendez MF, Miyagawa T, Pantelyat A, Pascual B, Masdeu J, Paulson HL, Petrucelli L, Pressman P, Rademakers R, Ramos EM, Rascovsky K, Roberson ED, Savica R, Snyder A, Sullivan AC, Tartaglia MC, Vandebergh M, Boeve BF, Rosen HJ, Rojas JC, Boxer AL, Casaletto KB. Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration. Nat Aging. 2025 Jun; 5(6):1143-1158.
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Hughes LE, Adams NE, Rouse MA, Naessens M, Shaw A, Murley AG, Cope TE, Holland N, Nesbitt D, Street D, Whiteside DJ, Rowe JB. GABAergic modulation of beta power enhances motor adaptation in frontotemporal lobar degeneration. Alzheimers Dement. 2025 May; 21(5):e14531.
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Perry A, Hughes LE, Adams NE, Naessens M, Kloosterman NA, Rouse MA, Murley AG, Street D, Jones PS, Rowe JB. Frontotemporal lobar degeneration changes neuronal beta-frequency dynamics during the mismatch negativity response. Neuroimage Clin. 2024; 44:103671.
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Staffaroni AM, Clark AL, Taylor JC, Heuer HW, Sanderson-Cimino M, Wise AB, Dhanam S, Cobigo Y, Wolf A, Manoochehri M, Forsberg L, Mester C, Rankin KP, Appleby BS, Bayram E, Bozoki A, Clark D, Darby RR, Domoto-Reilly K, Fields JA, Galasko D, Geschwind D, Ghoshal N, Graff-Radford N, Grossman M, Hsiung GY, Huey ED, Jones DT, Lapid MI, Litvan I, Masdeu JC, Massimo L, Mendez MF, Miyagawa T, Pascual B, Pressman P, Ramanan VK, Ramos EM, Rascovsky K, Roberson ED, Tartaglia MC, Wong B, Miller BL, Kornak J, Kremers W, Hassenstab J, Kramer JH, Boeve BF, Rosen HJ, Boxer AL. Reliability and Validity of Smartphone Cognitive Testing for Frontotemporal Lobar Degeneration. JAMA Netw Open. 2024 04 01; 7(4):e244266.
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Greenwood JD, Powell WC, Walczak MA. TMEM106B Fibrils from FTLD Patients and Healthy Controls. ACS Chem Neurosci. 2023 08 16; 14(16):2827-2829.
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Williams RS, Adams NE, Hughes LE, Rouse MA, Murley AG, Naessens M, Street D, Holland N, Rowe JB. Syndromes associated with frontotemporal lobar degeneration change response patterns on visual analogue scales. Sci Rep. 2023 06 02; 13(1):8939.
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Asken BM, Ljubenkov PA, Staffaroni AM, Casaletto KB, Vandevrede L, Cobigo Y, Rojas-Rodriguez JC, Rankin KP, Kornak J, Heuer H, Shigenaga J, Appleby BS, Bozoki AC, Domoto-Reilly K, Ghoshal N, Huey E, Litvan I, Masdeu JC, Mendez MF, Pascual B, Pressman P, Tartaglia MC, Kremers W, Forsberg LK, Boeve BF, Boxer AL, Rosen HJ, Kramer JH. Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration. J Neurol Neurosurg Psychiatry. 2023 07; 94(7):541-549.
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Perry A, Hughes LE, Adams N, Naessens M, Murley AG, Rouse MA, Street D, Jones PS, Cope TE, Kocagoncu E, Rowe JB. The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration. Transl Psychiatry. 2022 08 27; 12(1):348.
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Mao Q, Zheng X, Gefen T, Rogalski E, Spencer CL, Rademakers R, Fought AJ, Kohler M, Weintraub S, Xia H, Mesulam MM, Bigio EH. FTLD-TDP With and Without GRN Mutations Cause Different Patterns of CA1 Pathology. J Neuropathol Exp Neurol. 2019 09 01; 78(9):844-853.
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Sami S, Williams N, Hughes LE, Cope TE, Rittman T, Coyle-Gilchrist ITS, Henson RN, Rowe JB. Neurophysiological signatures of Alzheimer's disease and frontotemporal lobar degeneration: pathology versus phenotype. Brain. 2018 08 01; 141(8):2500-2510.
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