TNF-a downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-a antagonists to improve skin barrier.
Kim BE, Howell MD, Guttman-Yassky E, Guttman E, Gilleaudeau PM, Cardinale IR, Boguniewicz M, Krueger JG, Leung DY. TNF-a downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-a antagonists to improve skin barrier. J Invest Dermatol. 2011 Jun; 131(6):1272-9.