Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis.

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Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis.

Dhanalakshmi S, Mallikarjuna GU, Singh RP, Agarwal R. Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. Carcinogenesis. 2004 Aug; 25(8):1459-65.

View in: PubMed

subject areas

Animals
Anticarcinogenic Agents
Apoptosis
Cell Division
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Dimerization
DNA Damage
Epidermis
Female
Immunohistochemistry
In Situ Nick-End Labeling
Mice
Mice, Hairless
Models, Biological
Proliferating Cell Nuclear Antigen
Pyrimidine Dimers
Silymarin
Skin
Skin Neoplasms
Time Factors
Tumor Suppressor Protein p53
Ultraviolet Rays
Up-Regulation

authors with profiles

Rajesh Agarwal

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