IL-12-secreting CAR-T cells reprogram the tumor microenvironment and improve efficacy against heterogeneous models of glioblastoma.
Shen S, Mohan AA, Hotchkiss KM, Cook S, Patel K, Moelker E, Puviindran B, Gonzalez AT, Zaidi S, Spellicy S, Schwartz A, Suryadevara C, Wilkinson D, Ayasoufi K, Fecci PE, Sanchez-Perez L, Sampson J, Patel A. IL-12-secreting CAR-T cells reprogram the tumor microenvironment and improve efficacy against heterogeneous models of glioblastoma. J Immunother Cancer. 2026 Mar 24; 14(3).