Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
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Sabrina Leigh Spencer

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentBiochemistry

    Collapse Research 
    Collapse research activities and funding
    R01GM152642     (SPENCER, SABRINA LEIGH)Sep 1, 2024 - Aug 31, 2028
    NIH
    Molecular basis of cell-cycle plasticity and robustness
    Role: Principal Investigator
    R01AG082942     (SPENCER, SABRINA LEIGH)Sep 30, 2023 - May 31, 2028
    NIH
    Progressive states of cell-cycle withdrawal
    Role: Principal Investigator
    DP2CA238330     (SPENCER, SABRINA LEIGH)Sep 30, 2018 - May 31, 2023
    NIH
    PROLIFERATION-QUIESCENCE CONTROL IN SINGLE CELLS: INTEGRATION OF MITOGEN, NUTRIENT, AND STRESS SIGNALING
    Role: Principal Investigator
    K22CA188144     (SPENCER, SABRINA LEIGH)Sep 15, 2014 - Aug 31, 2017
    NIH
    Proliferation-quiescence control by integration of stress and mitogen signaling
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fernandez B, Passanisi V, Ashraf HM, Spencer SL. Single-cell RNA sequencing reveals distinct senotypes and a quiescence-senescence continuum at the transcriptome level following chemotherapy. bioRxiv. 2025 May 14. PMID: 40463227.
      View in: PubMed
    2. Jones T, Feng J, Luyties O, Cozzolino K, Sanford L, Rimel JK, Ebmeier CC, Shelby GS, Watts LP, Rodino J, Rajagopal N, Hu S, Brennan F, Maas ZL, Alnemy S, Richter WF, Koh AF, Cronin NB, Madduri A, Das J, Cooper E, Hamman KB, Carulli JP, Allen MA, Spencer S, Kotecha A, Marineau JJ, Greber BJ, Dowell RD, Taatjes DJ. TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network. Sci Adv. 2025 Feb 28; 11(9):eadr9660. PMID: 40020069.
      View in: PubMed
    3. Sama GR, Arguien MN, Hoffman TE, Fairbanks BD, Trujilo-Lemon M, Keyser S, Anseth KS, Spencer SL, Bowman CN. Design and Synthesis of Hydrolytically Degradable PEG Carbamate, Carbonate, and Ester Derivatives to Induce Reversible Biostasis. Biomacromolecules. 2025 Mar 10; 26(3):1850-1859. PMID: 39999569.
      View in: PubMed
    4. Sine C, Watts L, Fernandez B, Wang J, Knudsen E, Witkiewicz A, Spencer SL. p16 expression confers sensitivity to CDK2 inhibitors. bioRxiv. 2025 Feb 15. PMID: 39990340.
      View in: PubMed
    5. Hoffman TE, Tian C, Nangia V, Yang C, Regot S, Gerosa L, Spencer SL. CDK2 activity crosstalk on the ERK kinase translocation reporter can be resolved computationally. Cell Syst. 2025 Jan 15; 16(1):101162. PMID: 39818199.
      View in: PubMed
    6. Luyties O, Sanford L, Rodino J, Nagel M, Jones T, Rimel JK, Ebmeier CC, Shelby GS, Cozzolino K, Brennan F, Hartzog A, Saucedo MB, Watts LP, Spencer S, Kugel JF, Dowell RD, Taatjes DJ. Multi-omics and biochemical reconstitution reveal CDK7-dependent mechanisms controlling RNA polymerase II function at gene 5'- and 3'-ends. bioRxiv. 2025 Jan 08. PMID: 39829884.
      View in: PubMed
    7. Ill CR, Marikar NC, Nguyen V, Nangia V, Darnell AM, Vander Heiden MG, Reigan P, Spencer SL. BRAFV600 and ErbB inhibitors directly activate GCN2 in an off-target manner to limit cancer cell proliferation. bioRxiv. 2024 Dec 20. PMID: 39763857.
      View in: PubMed
    8. Dreyer J, Ricci G, van den Berg J, Bhardwaj V, Funk J, Armstrong C, van Batenburg V, Sine C, VanInsberghe MA, Tjeerdsma RB, Marsman R, Mandemaker IK, di Sanzo S, Costantini J, Manzo SG, Biran A, Burny C, van Vugt MATM, V?lker-Albert M, Groth A, Spencer SL, van Oudenaarden A, Mattiroli F. Acute multi-level response to defective de novo chromatin assembly in S-phase. Mol Cell. 2024 Dec 19; 84(24):4945. PMID: 39626659.
      View in: PubMed
    9. Dreyer J, Ricci G, van den Berg J, Bhardwaj V, Funk J, Armstrong C, van Batenburg V, Sine C, VanInsberghe MA, Tjeerdsma RB, Marsman R, Mandemaker IK, di Sanzo S, Costantini J, Manzo SG, Biran A, Burny C, van Vugt MATM, V?lker-Albert M, Groth A, Spencer SL, van Oudenaarden A, Mattiroli F. Acute multi-level response to defective de novo chromatin assembly in S-phase. Mol Cell. 2024 Dec 19; 84(24):4711-4728.e10. PMID: 39536749.
      View in: PubMed
    10. Dreyer J, Ricci G, van den Berg J, Bhardwaj V, Funk J, Armstrong C, van Batenburg V, Sine C, VanInsberghe MA, Marsman R, Mandemaker IK, di Sanzo S, Costantini J, Manzo SG, Biran A, Burny C, V?lker-Albert M, Groth A, Spencer SL, van Oudenaarden A, Mattiroli F. Acute multi-level response to defective de novo chromatin assembly in S-phase. bioRxiv. 2024 Mar 27. PMID: 38585916.
      View in: PubMed
    11. Watts LP, Spencer SL. A Highly Anticipated Selective Therapeutic Agent against CDK2: INX-315. Cancer Discov. 2024 Mar 01; 14(3):386-388. PMID: 38426558.
      View in: PubMed
    12. Jacobson KR, Saleh AM, Lipp SN, Tian C, Watson AR, Luetkemeyer CM, Ocken AR, Spencer SL, Kinzer-Ursem TL, Calve S. Extracellular matrix protein composition dynamically changes during murine forelimb development. iScience. 2024 Feb 16; 27(2):108838. PMID: 38303699.
      View in: PubMed
    13. McNally DL, Macdougall LJ, Kirkpatrick BE, Maduka CV, Hoffman TE, Fairbanks BD, Bowman CN, Spencer SL, Anseth KS. Reversible Intracellular Gelation of MCF10A Cells Enables Programmable Control Over 3D Spheroid Growth. Adv Healthc Mater. 2024 03; 13(7):e2302528. PMID: 38142299.
      View in: PubMed
    14. Rong Y, Darnell AM, Sapp KM, Vander Heiden MG, Spencer SL. Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids. Cell Rep. 2023 12 26; 42(12):113539. PMID: 38070134.
      View in: PubMed
    15. Hoffman TE, Nangia V, Ill CR, Passanisi VJ, Armstrong C, Yang C, Spencer SL. Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles. Sci Signal. 2023 08; 16(796):eade8744. PMID: 37527351.
      View in: PubMed
    16. Ashraf HM, Fernandez B, Spencer SL. The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal. Nat Commun. 2023 07 27; 14(1):4527. PMID: 37500655.
      View in: PubMed
    17. Armstrong C, Passanisi VJ, Ashraf HM, Spencer SL. Cyclin E/CDK2 and feedback from soluble histone protein regulate the S phase burst of histone biosynthesis. Cell Rep. 2023 07 25; 42(7):112768. PMID: 37428633.
      View in: PubMed
    18. Lammer NC, Ashraf HM, Ugay DA, Spencer SL, Allen MA, Batey RT, Wuttke DS. RNA binding by the glucocorticoid receptor attenuates dexamethasone-induced gene activation. Sci Rep. 2023 06 09; 13(1):9385. PMID: 37296231.
      View in: PubMed
    19. Arora M, Moser J, Hoffman TE, Watts LP, Min M, Musteanu M, Rong Y, Ill CR, Nangia V, Schneider J, Sanclemente M, Lapek J, Nguyen L, Niessen S, Dann S, VanArsdale T, Barbacid M, Miller N, Spencer SL. Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity. Cell. 2023 06 08; 186(12):2628-2643.e21. PMID: 37267950.
      View in: PubMed
    20. Hoffman TE, Yang C, Nangia V, Ill CR, Spencer SL. Multiple cancer types rapidly escape from multiple MAPK inhibitors to generate mutagenesis-prone subpopulations. bioRxiv. 2023 Mar 21. PMID: 36993538.
      View in: PubMed
    21. Ashraf HM, Fernandez B, Spencer SL. The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal. bioRxiv. 2023 Mar 21. PMID: 36993379.
      View in: PubMed
    22. Armstrong C, Passanisi VJ, Ashraf HM, Spencer SL. Cyclin E/CDK2 and feedback from soluble histone protein regulate the S phase burst of histone biosynthesis. bioRxiv. 2023 Mar 18. PMID: 36993620.
      View in: PubMed
    23. Chen JY, Hug C, Reyes J, Tian C, Gerosa L, Fr?hlich F, Ponsioen B, Snippert HJG, Spencer SL, Jambhekar A, Sorger PK, Lahav G. Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction. Cell Rep. 2023 03 28; 42(3):112252. PMID: 36920903.
      View in: PubMed
    24. Macdougall LJ, Hoffman TE, Kirkpatrick BE, Fairbanks BD, Bowman CN, Spencer SL, Anseth KS. Intracellular Crowding by Bio-Orthogonal Hydrogel Formation Induces Reversible Molecular Stasis. Adv Mater. 2022 Aug; 34(31):e2202882. PMID: 35671709.
      View in: PubMed
    25. Promislow D, Anderson RM, Scheffer M, Crespi B, DeGregori J, Harris K, Horowitz BN, Levine ME, Riolo MA, Schneider DS, Spencer SL, Valenzano DR, Hochberg ME. Resilience integrates concepts in aging research. iScience. 2022 May 20; 25(5):104199. PMID: 35494229.
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    26. Cable J, Elowitz MB, Domingos AI, Habib N, Itzkovitz S, Hamidzada H, Balzer MS, Yanai I, Liberali P, Whited J, Streets A, Cai L, Stergachis AB, Hong CKY, Keren L, Guilliams M, Alon U, Shalek AK, Hamel R, Pfau SJ, Raj A, Quake SR, Zhang NR, Fan J, Trapnell C, Wang B, Greenwald NF, Vento-Tormo R, Santos SDM, Spencer SL, Garcia HG, Arekatla G, Gaiti F, Arbel-Goren R, Rulands S, Junker JP, Klein AM, Morris SA, Murray JI, Galloway KE, Ratz M, Romeike M. Single cell biology-a Keystone Symposia report. Ann N Y Acad Sci. 2021 12; 1506(1):74-97. PMID: 34605044.
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    27. Armstrong C, Spencer SL. Replication-dependent histone biosynthesis is coupled to cell-cycle commitment. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). PMID: 34326254.
      View in: PubMed
    28. Yang C, Tian C, Hoffman TE, Jacobsen NK, Spencer SL. Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling. Nat Commun. 2021 03 19; 12(1):1747. PMID: 33741929.
      View in: PubMed
    29. Adikes RC, Kohrman AQ, Martinez MAQ, Palmisano NJ, Smith JJ, Medwig-Kinney TN, Min M, Sallee MD, Ahmed OB, Kim N, Liu S, Morabito RD, Weeks N, Zhao Q, Zhang W, Feldman JL, Barkoulas M, Pani AM, Spencer SL, Martin BL, Matus DQ. Visualizing the metazoan proliferation-quiescence decision in vivo. Elife. 2020 12 22; 9. PMID: 33350383.
      View in: PubMed
    30. Tian C, Yang C, Spencer SL. EllipTrack: A Global-Local Cell-Tracking Pipeline for 2D Fluorescence Time-Lapse Microscopy. Cell Rep. 2020 08 04; 32(5):107984. PMID: 32755578.
      View in: PubMed
    31. Min M, Rong Y, Tian C, Spencer SL. Temporal integration of mitogen history in mother cells controls proliferation of daughter cells. Science. 2020 06 12; 368(6496):1261-1265. PMID: 32241885.
      View in: PubMed
    32. Ashraf HM, Moser J, Spencer SL. Senescence Evasion in Chemotherapy: A Sweet Spot for p21. Cell. 2019 07 11; 178(2):267-269. PMID: 31299197.
      View in: PubMed
    33. Min M, Spencer SL. Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways. PLoS Biol. 2019 03; 17(3):e3000178. PMID: 30865623.
      View in: PubMed
    34. Moser J, Miller I, Carter D, Spencer SL. Control of the Restriction Point by Rb and p21. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):E8219-E8227. PMID: 30111539.
      View in: PubMed
    35. Miller I, Min M, Yang C, Tian C, Gookin S, Carter D, Spencer SL. Ki67 is a Graded Rather than a Binary Marker of Proliferation versus Quiescence. Cell Rep. 2018 07 31; 24(5):1105-1112.e5. PMID: 30067968.
      View in: PubMed
    36. Arora M, Spencer SL. A Cell-Cycle "Safe Space" for Surviving Chemotherapy. Cell Syst. 2017 09 27; 5(3):161-162. PMID: 28957649.
      View in: PubMed
    37. Gookin S, Min M, Phadke H, Chung M, Moser J, Miller I, Carter D, Spencer SL. A map of protein dynamics during cell-cycle progression and cell-cycle exit. PLoS Biol. 2017 Sep; 15(9):e2003268. PMID: 28892491.
      View in: PubMed
    38. Arora M, Moser J, Phadke H, Basha AA, Spencer SL. Endogenous Replication Stress in Mother Cells Leads to Quiescence of Daughter Cells. Cell Rep. 2017 05 16; 19(7):1351-1364. PMID: 28514656.
      View in: PubMed
    39. Cappell SD, Chung M, Jaimovich A, Spencer SL, Meyer T. Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry. Cell. 2016 Jun 30; 166(1):167-80. PMID: 27368103.
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    40. Overton KW, Spencer SL, Noderer WL, Meyer T, Wang CL. Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):E4386-93. PMID: 25267623.
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    41. Spencer SL, Cappell SD, Tsai FC, Overton KW, Wang CL, Meyer T. The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell. 2013 Oct 10; 155(2):369-83. PMID: 24075009.
      View in: PubMed
    42. Flusberg DA, Roux J, Spencer SL, Sorger PK. Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes. Mol Biol Cell. 2013 Jul; 24(14):2186-200. PMID: 23699397.
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    43. Gaudet S, Spencer SL, Chen WW, Sorger PK. Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis. PLoS Comput Biol. 2012; 8(4):e1002482. PMID: 22570596.
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    44. Spencer SL, Sorger PK. Measuring and modeling apoptosis in single cells. Cell. 2011 Mar 18; 144(6):926-39. PMID: 21414484.
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    45. Kim KA, Spencer SL, Albeck JG, Burke JM, Sorger PK, Gaudet S, Kim DH. Systematic calibration of a cell signaling network model. BMC Bioinformatics. 2010 Apr 23; 11:202. PMID: 20416044.
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    46. Niepel M, Spencer SL, Sorger PK. Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr Opin Chem Biol. 2009 Dec; 13(5-6):556-61. PMID: 19833543.
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    47. Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature. 2009 May 21; 459(7245):428-32. PMID: 19363473.
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    48. Pepper JW, Scott Findlay C, Kassen R, Spencer SL, Maley CC. Cancer research meets evolutionary biology. Evol Appl. 2009 Feb; 2(1):62-70. PMID: 25567847.
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    49. Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol. 2008 Dec 02; 6(12):2831-52. PMID: 19053173.
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    50. Spencer SL, Gerety RA, Pienta KJ, Forrest S. Modeling somatic evolution in tumorigenesis. PLoS Comput Biol. 2006 Aug 18; 2(8):e108. PMID: 16933983.
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    51. Spencer SL, Berryman MJ, Garc?a JA, Abbott D. An ordinary differential equation model for the multistep transformation to cancer. J Theor Biol. 2004 Dec 21; 231(4):515-24. PMID: 15488528.
      View in: PubMed
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