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Sabrina Leigh Spencer

TitleAsst Professor
InstitutionUniversity of Colorado Boulder

    Collapse Research 
    Collapse research activities and funding
    K22CA188144     (SPENCER, SABRINA LEIGH)Sep 15, 2014 - Aug 31, 2017
    Proliferation-quiescence control by integration of stress and mitogen signaling
    Role: Principal Investigator

    DP2CA238330     (SPENCER, SABRINA LEIGH)Sep 30, 2018 - Jun 30, 2023
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Min M, Spencer SL. Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways. PLoS Biol. 2019 Mar 13; 17(3):e3000178. PMID: 30865623.
      View in: PubMed
    2. Moser J, Miller I, Carter D, Spencer SL. Control of the Restriction Point by Rb and p21. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):E8219-E8227. PMID: 30111539.
      View in: PubMed
    3. Miller I, Min M, Yang C, Tian C, Gookin S, Carter D, Spencer SL. Ki67 is a Graded Rather than a Binary Marker of Proliferation versus Quiescence. Cell Rep. 2018 Jul 31; 24(5):1105-1112.e5. PMID: 30067968.
      View in: PubMed
    4. Arora M, Spencer SL. A Cell-Cycle "Safe Space" for Surviving Chemotherapy. Cell Syst. 2017 Sep 27; 5(3):161-162. PMID: 28957649.
      View in: PubMed
    5. Gookin S, Min M, Phadke H, Chung M, Moser J, Miller I, Carter D, Spencer SL. A map of protein dynamics during cell-cycle progression and cell-cycle exit. PLoS Biol. 2017 Sep; 15(9):e2003268. PMID: 28892491.
      View in: PubMed
    6. Arora M, Moser J, Phadke H, Basha AA, Spencer SL. Endogenous Replication Stress in Mother Cells Leads to Quiescence of Daughter Cells. Cell Rep. 2017 05 16; 19(7):1351-1364. PMID: 28514656.
      View in: PubMed
    7. Cappell SD, Chung M, Jaimovich A, Spencer SL, Meyer T. Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry. Cell. 2016 Jun 30; 166(1):167-80. PMID: 27368103.
      View in: PubMed
    8. Overton KW, Spencer SL, Noderer WL, Meyer T, Wang CL. Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):E4386-93. PMID: 25267623; PMCID: PMC4205626.
    9. Spencer SL, Cappell SD, Tsai FC, Overton KW, Wang CL, Meyer T. The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell. 2013 Oct 10; 155(2):369-83. PMID: 24075009; PMCID: PMC4001917.
    10. Flusberg DA, Roux J, Spencer SL, Sorger PK. Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes. Mol Biol Cell. 2013 Jul; 24(14):2186-200. PMID: 23699397; PMCID: PMC3708725.
    11. Gaudet S, Spencer SL, Chen WW, Sorger PK. Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis. PLoS Comput Biol. 2012; 8(4):e1002482. PMID: 22570596; PMCID: PMC3343095.
    12. Spencer SL, Sorger PK. Measuring and modeling apoptosis in single cells. Cell. 2011 Mar 18; 144(6):926-39. PMID: 21414484; PMCID: PMC3087303.
    13. Kim KA, Spencer SL, Albeck JG, Burke JM, Sorger PK, Gaudet S, Kim DH. Systematic calibration of a cell signaling network model. BMC Bioinformatics. 2010 Apr 23; 11:202. PMID: 20416044.
      View in: PubMed
    14. Niepel M, Spencer SL, Sorger PK. Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr Opin Chem Biol. 2009 Dec; 13(5-6):556-61. PMID: 19833543; PMCID: PMC2975492.
    15. Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature. 2009 May 21; 459(7245):428-32. PMID: 19363473; PMCID: PMC2858974.
    16. Pepper JW, Scott Findlay C, Kassen R, Spencer SL, Maley CC. Cancer research meets evolutionary biology. Evol Appl. 2009 Feb; 2(1):62-70. PMID: 25567847; PMCID: PMC3352411.
    17. Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol. 2008 Dec 02; 6(12):2831-52. PMID: 19053173.
      View in: PubMed
    18. Spencer SL, Gerety RA, Pienta KJ, Forrest S. Modeling somatic evolution in tumorigenesis. PLoS Comput Biol. 2006 Aug 18; 2(8):e108. PMID: 16933983; PMCID: PMC1550273.
    19. Spencer SL, Berryman MJ, GarcĂ­a JA, Abbott D. An ordinary differential equation model for the multistep transformation to cancer. J Theor Biol. 2004 Dec 21; 231(4):515-24. PMID: 15488528.
      View in: PubMed
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