 Alex Christopher Hughes
| Title | Assistant Research Professor |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-MED |
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ORCID
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 Overview Our work focuses on investigating the molecular underpinnings of and developing new treatments for prostate and bladder cancer. I work closely with clinicians who focus on genitourinary cancers who help guide our investigative avenues. Our prostate cancer work focuses on understanding the molecular differences of castrate resistant and high testosterone resistant cell models developed in our lab. Our bladder cancer work focuses on studying how bladder cell models develop resistance to frontline cancer treatments. We also have ongoing collaborations with groups who have developed novel nanotechnologies for bladder cancer treatment.
Bibliographic
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Hughes A.C., Graham, L. S. Treatment Approaches and Future Directions for Neuroendocrine Prostate Cancer and Other Aggressive Variant Prostate Cancers. Advances in Oncology. 2026; 6(1):165-172.
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Ogg MC, Lansdell BJ, Franks HT, Hughes AC, Lee J, Nolen HG, Shirinifard A, Schwarz LA. Locus coeruleus norepinephrine neurons facilitate orbitofrontal cortex remapping and behavioral flexibility. Cell Rep. 2025 Dec 23; 44(12):116687. PMID: 41389209.
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Hughes AC, Pittman BG, Xu B, Gammons JW, Webb CM, Nolen HG, Chapman P, Bikoff JB, Schwarz LA. Author Correction: A single-vector intersectional AAV strategy for interrogating cellular diversity and brain function. Nat Neurosci. 2025 Dec; 28(12):2644. PMID: 41145889.
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Becker LJ, Martin MM, Hughes AC, Mulvey B, Kuo CC, Piantadosi SC, Bruchas MR, Martinowich K, Meye FJ, Schwarz LA, Weinshenker D, McCall JG, Riga D. Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system. Pharmacol Rev. 2025 09; 77(5):100081. PMID: 40749333.
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Lee JG, Petraccione J, Trese KA, Hughes AC, Ausec TR, Salzmann-Sullivan M, Su LJ, Kim MT, Roh S, Goodwin AP, Feng FX, Flaig TW, Shields CW. Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers. Adv Mater. 2025 Sep; 37(38):e2505231. PMID: 40611758.
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Hughes AC, Pittman BG, Xu B, Gammons JW, Webb CM, Nolen HG, Chapman P, Bikoff JB, Schwarz LA. A single-vector intersectional AAV strategy for interrogating cellular diversity and brain function. Nat Neurosci. 2024 Jul; 27(7):1400-1410. PMID: 38802592.
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Hughes AC, Pollard BG, Xu B, Gammons JW, Chapman P, Bikoff JB, Schwarz LA. A Novel Single Vector Intersectional AAV Strategy for Interrogating Cellular Diversity and Brain Function. bioRxiv. 2023 Feb 08. PMID: 36798174.
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Perera YR, Xu JX, Amarasekara DL, Hughes AC, Abbood I, Fitzkee NC. Understanding the Adsorption of Peptides and Proteins onto PEGylated Gold Nanoparticles. Molecules. 2021 Sep 24; 26(19). PMID: 34641335.
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Perera YR, South TM, Hughes AC, Parkhurst AN, Williams OC, Davidson MB, Wilks CA, Mlsna DA, Fitzkee NC. Using NMR Spectroscopy To Measure Protein Binding Capacity on Gold Nanoparticles. J Chem Educ. 2020 Mar 10; 97(3):820-824. PMID: 34045774.
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Rezai S, Hughes AC, Larsen TB, Fuller PN, Henderson CE. Atypical Amniotic Fluid Embolism Managed with a Novel Therapeutic Regimen. Case Rep Obstet Gynecol. 2017; 2017:8458375. PMID: 29430313.
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Martin EW, Holehouse AS, Grace CR, Hughes A, Pappu RV, Mittag T. Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation. J Am Chem Soc. 2016 11 30; 138(47):15323-15335. PMID: 27807972.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2016 | 1 | | 2017 | 1 | | 2020 | 1 | | 2021 | 1 | | 2023 | 1 | | 2024 | 1 | | 2025 | 4 | | 2026 | 1 |
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