Hybrid insulin peptide isomers spontaneously form in pancreatic beta-cells from an aspartic anhydride intermediate.
Crawford SA, Groegler J, Dang M, Michel C, Powell RL, Hohenstein AC, Reyes K, Haskins K, Wiles TA, Delong T. Hybrid insulin peptide isomers spontaneously form in pancreatic beta-cells from an aspartic anhydride intermediate. J Biol Chem. 2023 11; 299(11):105264.