Kristyn Simcha Masters
Title | Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | CEDC-Bioengineering |
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Title | Chair |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | CEDC-Bioengineering |
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Title | Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | CEDC-Bioengineering |
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Research R01HL172046 (MASTERS, KRISTYN S)Jan 1, 2024 - Dec 31, 2027 NIH Engineered models of age-related biochemical, biophysical, and hormonal changes to elucidate mechanisms of aortic valve disease onset Role: Principal Investigator |
| R01GM143795 (KREEGER, PAMELA K)Sep 1, 2022 - Aug 31, 2026 NIH Deciphering mechanisms that drive collective cell migration Role: Co-Principal Investigator |
| R01HL141181 (LIU, BO)Jan 1, 2019 - Dec 31, 2023 NIH Engineered Models of Diseased Heart Valves to Study Sex Bias in Disease Progression Role: Co-Principal Investigator |
| R01CA232517 (CAMPAGNOLA, PAUL J;KREEGER, PAMELA K ;MASTERS, KRISTYN S)Sep 1, 2018 - Aug 31, 2023 NIH Engineered ECM platforms to analyze progression in high grade serous ovarian cancer Role: Co-Principal Investigator |
| R21EY026222 (MASTERS, KRISTYN S)Aug 1, 2016 - Jul 31, 2019 NIH Identification of novel therapeutic targets for age-related macular degeneration via a combined tissue engineering and systems biology approach Role: Principal Investigator |
| R21CA202040 (KREEGER, PAMELA K)Dec 1, 2015 - Nov 30, 2018 NIH Impact of soluble and physical stimuli on tumor angiogenesis and drug sensitivity Role: Co-Principal Investigator |
| R21EB019508 (MASTERS, KRISTYN S)Sep 1, 2015 - Jun 30, 2019 NIH Development of Complex Culture Systems to Study Valvular Dysfunction Role: Principal Investigator |
| R01GM099031 (MASTERS, KRISTYN S)Sep 1, 2011 - Dec 31, 2016 NIH Combinatorial analysis of migration stimuli for enhanced wound healing Role: Principal Investigator |
| R21EB013259 (MASTERS, KRISTYN S)Apr 1, 2011 - Sep 30, 2013 NIH Nylon-3 Copolymers as Synthetic Cell-Adhesive Moieties for Tissue Engineering Role: Principal Investigator |
| R01HL093281 (MASTERS, KRISTYN S)Apr 1, 2009 - Apr 30, 2016 NIH Creating Engineered Models of Valvular Disease to Study Anti-Calcific Therapies Role: Principal Investigator |
| R21EB005440 (MASTERS, KRISTYN S)Aug 16, 2006 - Jul 31, 2010 NIH Micropatterned EGF of Accelerated Wound Healing Role: Principal Investigator |
Bibliographic
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Adler FR, Anderson ARA, Bhushan A, Bogdan P, Bravo-Cordero JJ, Brock A, Chen Y, Cukierman E, DelGiorno KE, Denis GV, Ferrall-Fairbanks MC, Gartner ZJ, Germain RN, Gordon DM, Hunter G, Jolly MK, Karacosta LG, Mythreye K, Katira P, Kulkarni RP, Kutys ML, Lander AD, Laughney AM, Levine H, Lou E, Lowenstein PR, Masters KS, Pe'er D, Peyton SR, Platt MO, Purvis JE, Quon G, Richer JK, Riddle NC, Rodriguez A, Snyder JC, Lee Szeto G, Tomlin CJ, Yanai I, Zervantonakis IK, Dueck H. Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. Cell Syst. 2023 04 19; 14(4):252-257. PMID: 37080161.
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Floy ME, Shabnam F, Givens SE, Patil VA, Ding Y, Li G, Roy S, Raval AN, Schmuck EG, Masters KS, Ogle BM, Palecek SP. Identifying molecular and functional similarities and differences between human primary cardiac valve interstitial cells and ventricular fibroblasts. Front Bioeng Biotechnol. 2023; 11:1102487. PMID: 37051268.
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Simon LR, Scott AJ, Figueroa Rios L, Zembles J, Masters KS. Cellular-scale sex differences in extracellular matrix remodeling by valvular interstitial cells. Heart Vessels. 2023 Jan; 38(1):122-130. PMID: 36070095.
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Renner CM, Visetsouk MR, Kreeger PK, Masters KS. Multispectral Staining and Analysis of Extracellular Matrix. Methods Mol Biol. 2022; 2424:105-119. PMID: 34918289.
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Renner C, Gomez C, Visetsouk MR, Taha I, Khan A, McGregor SM, Weisman P, Naba A, Masters KS, Kreeger PK. Multi-modal Profiling of the Extracellular Matrix of Human Fallopian Tubes and Serous Tubal Intraepithelial Carcinomas. J Histochem Cytochem. 2022 02; 70(2):151-168. PMID: 34866441.
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Nelson V, Patil V, Simon LR, Schmidt K, McCoy CM, Masters KS. Angiogenic Secretion Profile of Valvular Interstitial Cells Varies With Cellular Sex and Phenotype. Front Cardiovasc Med. 2021; 8:736303. PMID: 34527715.
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Scott AJ, Simon LR, Hutson HN, Porras AM, Masters KS. Engineering the aortic valve extracellular matrix through stages of development, aging, and disease. J Mol Cell Cardiol. 2021 12; 161:1-8. PMID: 34339757.
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Wang Y, Gloss B, Tang B, Dervish S, Santner-Nanan B, Whitehead C, Masters K, Skarratt K, Teoh S, Schibeci S, Fewings N, Brignone C, Triebel F, Booth D, McLean A, Nalos M. Immunophenotyping of Peripheral Blood Mononuclear Cells in Septic Shock Patients With High-Dimensional Flow Cytometry Analysis Reveals Two Subgroups With Differential Responses to Immunostimulant Drugs. Front Immunol. 2021; 12:634127. PMID: 33828550.
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Stevens KR, Masters KS, Imoukhuede PI, Haynes KA, Setton LA, Cosgriff-Hernandez E, Lediju Bell MA, Rangamani P, Sakiyama-Elbert SE, Finley SD, Willits RK, Koppes AN, Chesler NC, Christman KL, Allen JB, Wong JY, El-Samad H, Desai TA, Eniola-Adefeso O. Fund Black scientists. Cell. 2021 02 04; 184(3):561-565. PMID: 33503447.
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Patil VA, Masters KS. Engineered Collagen Matrices. Bioengineering (Basel). 2020 Dec 16; 7(4). PMID: 33339157.
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Kreeger PK, Brock A, Gibbs HC, Grande-Allen KJ, Huang AH, Masters KS, Rangamani P, Reagan MR, Servoss SL. Ten simple rules for women principal investigators during a pandemic. PLoS Comput Biol. 2020 10; 16(10):e1008370. PMID: 33119585.
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Micek HM, Visetsouk MR, Masters KS, Kreeger PK. Engineering the Extracellular Matrix to Model the Evolving Tumor Microenvironment. iScience. 2020 Nov 20; 23(11):101742. PMID: 33225247.
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Bilger A, King RE, Schroeder JP, Piette JT, Hinshaw LA, Kurth AD, AlRamahi RW, Barthel MV, Ward-Shaw ET, Buehler D, Masters KS, Thibeault SL, Lambert PF. A Mouse Model of Oropharyngeal Papillomavirus-Induced Neoplasia Using Novel Tools for Infection and Nasal Anesthesia. Viruses. 2020 04 16; 12(4). PMID: 32316091.
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Simon LR, Masters KS. Disease-inspired tissue engineering: Investigation of cardiovascular pathologies. ACS Biomater Sci Eng. 2020 05 11; 6(5):2518-2532. PMID: 32974421.
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Berger AJ, Renner CM, Hale I, Yang X, Ponik SM, Weisman PS, Masters KS, Kreeger PK. Scaffold stiffness influences breast cancer cell invasion via EGFR-linked Mena upregulation and matrix remodeling. Matrix Biol. 2020 01; 85-86:80-93. PMID: 31323325.
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Kim CS, Yang X, Jacobsen S, Masters KS, Kreeger PK. Leader cell PLC?1 activation during keratinocyte collective migration is induced by EGFR localization and clustering. Bioeng Transl Med. 2019 Sep; 4(3):e10138. PMID: 31572796.
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Kreeger PK, Strong LE, Masters KS. Engineering Approaches to Study Cellular Decision Making. Annu Rev Biomed Eng. 2018 06 04; 20:49-72. PMID: 29328778.
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Porras AM, Westlund JA, Evans AD, Masters KS. Creation of disease-inspired biomaterial environments to mimic pathological events in early calcific aortic valve disease. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E363-E371. PMID: 29282325.
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Masters KS, Kreeger PK. Ten simple rules for developing a mentor-mentee expectations document. PLoS Comput Biol. 2017 09; 13(9):e1005709. PMID: 28934208.
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Berger AJ, Linsmeier KM, Kreeger PK, Masters KS. Decoupling the effects of stiffness and fiber density on cellular behaviors via an interpenetrating network of gelatin-methacrylate and collagen. Biomaterials. 2017 Oct; 141:125-135. PMID: 28683337.
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Arzani A, Masters KS, Mofrad MRK. Multiscale Systems Biology Model of Calcific Aortic Valve Disease Progression. ACS Biomater Sci Eng. 2017 Nov 13; 3(11):2922-2933. PMID: 33418713.
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Porras AM, van Engeland NC, Marchbanks E, McCormack A, Bouten CV, Yacoub MH, Latif N, Masters KS. Robust Generation of Quiescent Porcine Valvular Interstitial Cell Cultures. J Am Heart Assoc. 2017 Mar 14; 6(3). PMID: 28292746.
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Porras AM, McCoy CM, Masters KS. Calcific Aortic Valve Disease: A Battle of the Sexes. Circ Res. 2017 02 17; 120(4):604-606. PMID: 28209788.
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Hutson HN, Marohl T, Anderson M, Eliceiri K, Campagnola P, Masters KS. Calcific Aortic Valve Disease Is Associated with Layer-Specific Alterations in Collagen Architecture. PLoS One. 2016; 11(9):e0163858. PMID: 27685946.
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Kim CS, Mitchell IP, Desotell AW, Kreeger PK, Masters KS. Immobilized epidermal growth factor stimulates persistent, directed keratinocyte migration via activation of PLC?1. FASEB J. 2016 07; 30(7):2580-90. PMID: 27025961.
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Porras AM, Hutson HN, Berger AJ, Masters KS. Engineering approaches to study fibrosis in 3-D in vitro systems. Curr Opin Biotechnol. 2016 08; 40:24-30. PMID: 26926460.
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Wickert LE, Pomerenke S, Mitchell I, Masters KS, Kreeger PK. Hierarchy of cellular decisions in collective behavior: Implications for wound healing. Sci Rep. 2016 Feb 02; 6:20139. PMID: 26832302.
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Porras AM, Shanmuganayagam D, Meudt JJ, Krueger CG, Hacker TA, Rahko PS, Reed JD, Masters KS. Development of Aortic Valve Disease in Familial Hypercholesterolemic Swine: Implications for Elucidating Disease Etiology. J Am Heart Assoc. 2015 Oct 27; 4(10):e002254. PMID: 26508741.
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Porras AM, Masters KS. Wave mice: a new tool in the quest to characterize aortic valvular disease etiologies. J Thorac Dis. 2015 Sep; 7(9):E332-4. PMID: 26543623.
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Laperle A, Hsiao C, Lampe M, Mortier J, Saha K, Palecek SP, Masters KS. a-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal. Stem Cell Reports. 2015 Aug 11; 5(2):195-206. PMID: 26235893.
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Liu R, Chen X, Falk SP, Masters KS, Weisblum B, Gellman SH. Nylon-3 polymers active against drug-resistant Candida albicans biofilms. J Am Chem Soc. 2015 Feb 18; 137(6):2183-6. PMID: 25650957.
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Nadithe V, Liu R, Killinger BA, Movassaghian S, Kim NH, Moszczynska AB, Masters KS, Gellman SH, Merkel OM. Screening nylon-3 polymers, a new class of cationic amphiphiles, for siRNA delivery. Mol Pharm. 2015 Feb 02; 12(2):362-74. PMID: 25437915.
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Porras AM, Shanmuganayagam D, Meudt JJ, Krueger CG, Reed JD, Masters KS. Gene Expression Profiling of Valvular Interstitial Cells in Rapacz Familial Hypercholesterolemic Swine. Genom Data. 2014 Dec 01; 2:261-263. PMID: 25229013.
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Laperle A, Masters KS, Palecek SP. Influence of substrate composition on human embryonic stem cell differentiation and extracellular matrix production in embryoid bodies. Biotechnol Prog. 2015 Jan-Feb; 31(1):212-9. PMID: 25311359.
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Chakraborty S, Liu R, Hayouka Z, Chen X, Ehrhardt J, Lu Q, Burke E, Yang Y, Weisblum B, Wong GC, Masters KS, Gellman SH. Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits. J Am Chem Soc. 2014 Oct 15; 136(41):14530-5. PMID: 25269798.
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Moftakhar R, Xu F, Aagaard-Kienitz B, Consigny DW, Grinde JR, Hart K, Flanagan CE, Crone WC, Masters KS. Preliminary in vivo evaluation of a novel intrasaccular cerebral aneurysm occlusion device. J Neurointerv Surg. 2015 Aug; 7(8):584-90. PMID: 24891454.
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Liu R, Chen X, Falk SP, Mowery BP, Karlsson AJ, Weisblum B, Palecek SP, Masters KS, Gellman SH. Structure-activity relationships among antifungal nylon-3 polymers: identification of materials active against drug-resistant strains of Candida albicans. J Am Chem Soc. 2014 Mar 19; 136(11):4333-42. PMID: 24606327.
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Liu R, Chen X, Chakraborty S, Lemke JJ, Hayouka Z, Chow C, Welch RA, Weisblum B, Masters KS, Gellman SH. Tuning the biological activity profile of antibacterial polymers via subunit substitution pattern. J Am Chem Soc. 2014 Mar 19; 136(11):4410-8. PMID: 24601599.
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Rodriguez KJ, Piechura LM, Porras AM, Masters KS. Manipulation of valve composition to elucidate the role of collagen in aortic valve calcification. BMC Cardiovasc Disord. 2014 Mar 01; 14:29. PMID: 24581344.
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Ruiz A, Rathnam KR, Masters KS. Effect of hyaluronic acid incorporation method on the stability and biological properties of polyurethane-hyaluronic acid biomaterials. J Mater Sci Mater Med. 2014 Feb; 25(2):487-98. PMID: 24276670.
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Liu R, Chen X, Gellman SH, Masters KS. Nylon-3 polymers that enable selective culture of endothelial cells. J Am Chem Soc. 2013 Nov 06; 135(44):16296-9. PMID: 24156536.
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Chakraborty S, Liu R, Lemke JJ, Hayouka Z, Welch RA, Weisblum B, Masters KS, Gellman SH. Effects of Cyclic vs. Acyclic Hydrophobic Subunits on the Chemical Structure and Biological Properties of Nylon-3 Co-Polymers. ACS Macro Lett. 2013 Aug 20; 2(8). PMID: 24349873.
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Liu R, Chen X, Hayouka Z, Chakraborty S, Falk SP, Weisblum B, Masters KS, Gellman SH. Nylon-3 polymers with selective antifungal activity. J Am Chem Soc. 2013 Apr 10; 135(14):5270-3. PMID: 23547967.
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Ruiz A, Flanagan CE, Masters KS. Differential support of cell adhesion and growth by copolymers of polyurethane with hyaluronic acid. J Biomed Mater Res A. 2013 Oct; 101(10):2870-82. PMID: 23505036.
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Pfund C, House S, Spencer K, Asquith P, Carney P, Masters KS, McGee R, Shanedling J, Vecchiarelli S, Fleming M. A research mentor training curriculum for clinical and translational researchers. Clin Transl Sci. 2013 Feb; 6(1):26-33. PMID: 23399086.
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Monzack EL, Masters KS. A time course investigation of the statin paradox among valvular interstitial cell phenotypes. Am J Physiol Heart Circ Physiol. 2012 Oct 01; 303(7):H903-9. PMID: 22904157.
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McCoy CM, Nicholas DQ, Masters KS. Sex-related differences in gene expression by porcine aortic valvular interstitial cells. PLoS One. 2012; 7(7):e39980. PMID: 22808080.
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Liu R, Vang KZ, Kreeger PK, Gellman SH, Masters KS. Experimental and computational analysis of cellular interactions with nylon-3-bearing substrates. J Biomed Mater Res A. 2012 Oct; 100(10):2750-9. PMID: 22623026.
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Liu R, Masters KS, Gellman SH. Polymer chain length effects on fibroblast attachment on nylon-3-modified surfaces. Biomacromolecules. 2012 Apr 09; 13(4):1100-5. PMID: 22455338.
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Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update. Circulation. 2011 Oct 18; 124(16):1783-91. PMID: 22007101.
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Monzack EL, Masters KS. Can valvular interstitial cells become true osteoblasts? A side-by-side comparison. J Heart Valve Dis. 2011 Jul; 20(4):449-63. PMID: 21863660.
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Masters KS. Covalent growth factor immobilization strategies for tissue repair and regeneration. Macromol Biosci. 2011 Sep 09; 11(9):1149-63. PMID: 21509937.
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Gu X, Masters KS. Role of the Rho pathway in regulating valvular interstitial cell phenotype and nodule formation. Am J Physiol Heart Circ Physiol. 2011 Feb; 300(2):H448-58. PMID: 21131478.
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Xu F, Flanagan CE, Ruiz A, Crone WC, Masters KS. Polyurethane/dermatan sulfate copolymers as hemocompatible, non-biofouling materials. Macromol Biosci. 2011 Feb 11; 11(2):257-66. PMID: 21077227.
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Rodriguez KJ, Piechura LM, Masters KS. Regulation of valvular interstitial cell phenotype and function by hyaluronic acid in 2-D and 3-D culture environments. Matrix Biol. 2011 Jan; 30(1):70-82. PMID: 20884350.
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Gu X, Masters KS. Regulation of valvular interstitial cell calcification by adhesive peptide sequences. J Biomed Mater Res A. 2010 Jun 15; 93(4):1620-30. PMID: 20073077.
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Christ KV, Williamson KB, Masters KS, Turner KT. Measurement of single-cell adhesion strength using a microfluidic assay. Biomed Microdevices. 2010 Jun; 12(3):443-55. PMID: 20213215.
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Puccinelli TJ, Bertics PJ, Masters KS. Regulation of keratinocyte signaling and function via changes in epidermal growth factor presentation. Acta Biomater. 2010 Sep; 6(9):3415-25. PMID: 20398806.
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Lee MR, Stahl SS, Gellman SH, Masters KS. Nylon-3 copolymers that generate cell-adhesive surfaces identified by library screening. J Am Chem Soc. 2009 Nov 25; 131(46):16779-89. PMID: 19886604.
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Stacey DH, Hanson SE, Lahvis G, Gutowski KA, Masters KS. In vitro adipogenic differentiation of preadipocytes varies with differentiation stimulus, culture dimensionality, and scaffold composition. Tissue Eng Part A. 2009 Nov; 15(11):3389-99. PMID: 19402786.
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Rodriguez KJ, Masters KS. Regulation of valvular interstitial cell calcification by components of the extracellular matrix. J Biomed Mater Res A. 2009 Sep 15; 90(4):1043-53. PMID: 18671262.
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Chuang TW, Masters KS. Regulation of polyurethane hemocompatibility and endothelialization by tethered hyaluronic acid oligosaccharides. Biomaterials. 2009 Oct; 30(29):5341-51. PMID: 19577800.
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Gu X, Masters KS. Role of the MAPK/ERK pathway in valvular interstitial cell calcification. Am J Physiol Heart Circ Physiol. 2009 Jun; 296(6):H1748-57. PMID: 19363136.
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Stefonek-Puccinelli TJ, Masters KS. Regulation of cell signaling and function via changes in growth factor presentation. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:1167-71. PMID: 19963489.
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Monzack EL, Gu X, Masters KS. Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. Arterioscler Thromb Vasc Biol. 2009 Feb; 29(2):246-53. PMID: 19023089.
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Stefonek-Puccinelli TJ, Masters KS. Co-immobilization of gradient-patterned growth factors for directed cell migration. Ann Biomed Eng. 2008 Dec; 36(12):2121-33. PMID: 18850272.
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Stefonek TJ, Masters KS. Immobilized gradients of epidermal growth factor promote accelerated and directed keratinocyte migration. Wound Repair Regen. 2007 Nov-Dec; 15(6):847-55. PMID: 18028133.
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Xu F, Nacker JC, Crone WC, Masters KS. The haemocompatibility of polyurethane-hyaluronic acid copolymers. Biomaterials. 2008 Jan; 29(2):150-60. PMID: 17936354.
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Sebra RP, Reddy SK, Masters KS, Bowman CN, Anseth KS. Controlled polymerization chemistry to graft architectures that influence cell-material interactions. Acta Biomater. 2007 Mar; 3(2):151-61. PMID: 17236829.
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Sebra RP, Masters KS, Cheung CY, Bowman CN, Anseth KS. Detection of antigens in biologically complex fluids with photografted whole antibodies. Anal Chem. 2006 May 01; 78(9):3144-51. PMID: 16643006.
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Sebra RP, Masters KS, Bowman CN, Anseth KS. Surface grafted antibodies: controlled architecture permits enhanced antigen detection. Langmuir. 2005 Nov 22; 21(24):10907-11. PMID: 16285751.
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Cushing MC, Jaeggli MP, Masters KS, Leinwand LA, Anseth KS. Serum deprivation improves seeding and repopulation of acellular matrices with valvular interstitial cells. J Biomed Mater Res A. 2005 Oct 01; 75(1):232-41. PMID: 16088888.
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Masters KS, Shah DN, Leinwand LA, Anseth KS. Crosslinked hyaluronan scaffolds as a biologically active carrier for valvular interstitial cells. Biomaterials. 2005 May; 26(15):2517-25. PMID: 15585254.
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Masters KS, Lipke EA, Rice EE, Liel MS, Myler HA, Zygourakis C, Tulis DA, West JL. Nitric oxide-generating hydrogels inhibit neointima formation. J Biomater Sci Polym Ed. 2005; 16(5):659-72. PMID: 16001723.
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Masters KS, Shah DN, Walker G, Leinwand LA, Anseth KS. Designing scaffolds for valvular interstitial cells: cell adhesion and function on naturally derived materials. J Biomed Mater Res A. 2004 Oct 01; 71(1):172-80. PMID: 15368267.
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Walker GA, Masters KS, Shah DN, Anseth KS, Leinwand LA. Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease. Circ Res. 2004 Aug 06; 95(3):253-60. PMID: 15217906.
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Schmedlen RH, Masters KS, West JL. Photocrosslinkable polyvinyl alcohol hydrogels that can be modified with cell adhesion peptides for use in tissue engineering. Biomaterials. 2002 Nov; 23(22):4325-32. PMID: 12219822.
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Year | Publications |
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2002 | 1 | 2004 | 2 | 2005 | 4 | 2006 | 1 | 2007 | 3 | 2008 | 2 | 2009 | 6 | 2010 | 6 | 2011 | 3 | 2012 | 5 | 2013 | 5 | 2014 | 8 | 2015 | 4 | 2016 | 4 | 2017 | 6 | 2018 | 1 | 2019 | 3 | 2020 | 4 | 2021 | 5 | 2022 | 2 | 2023 | 2 |
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