Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Aurelie M Ledreux

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-NS General Operations

    Collapse Research 
    Collapse research activities and funding
    R01AG071228     (GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER)Aug 15, 2021 - Apr 30, 2026
    NIH
    Exosome biology in Alzheimer's disease and concussion.
    Role: MPI
    R01AG070153     (LEDREUX, AURELIE)Sep 15, 2020 - Jun 30, 2025
    NIH
    Noradrenergic dysfunction in Down Syndrome
    Role: Principal Investigator
    AARG-565696     (Ledreux, Aurélie)Mar 1, 2018 - Feb 28, 2022
    Alzheimer's Association Research grant
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhou W, Graner M, Beseler C, Domashevich T, Selva S, Webster G, Ledreux A, Zizzo Z, Lundt M, Alvarez E, Yu X. Plasma IgG aggregates as biomarkers for multiple sclerosis. Clin Immunol. 2023 11; 256:109801. PMID: 37816415.
      View in: PubMed
    2. Nicastri CM, McFeeley BM, Simon SS, Ledreux A, H?kansson K, Granholm AC, Mohammed AH, Daffner KR. BDNF mediates improvement in cognitive performance after computerized cognitive training in healthy older adults. Alzheimers Dement (N Y). 2022; 8(1):e12337. PMID: 36089933.
      View in: PubMed
    3. Ahmed J, Fitch TC, Donnelly CM, Joseph JA, Ball TD, Bassil MM, Son A, Zhang C, Ledreux A, Horowitz S, Qin Y, Paredes D, Kumar S. Foldamers reveal and validate therapeutic targets associated with toxic a-synuclein self-assembly. Nat Commun. 2022 04 27; 13(1):2273. PMID: 35477706.
      View in: PubMed
    4. Mufson EJ, Ginsberg SD, Ma T, Ledreux A, Perez SE. Editorial: Down Syndrome, Neurodegeneration and Dementia. Front Aging Neurosci. 2021; 13:791044. PMID: 34975462.
      View in: PubMed
    5. Granholm AC, Ledreux A. Biomarkers show value of studying dementia in Down syndrome. Nat Rev Neurol. 2021 10; 17(10):599-600. PMID: 34465922.
      View in: PubMed
    6. Ledreux A, Thomas S, Hamlett ED, Trautman C, Gilmore A, Rickman Hager E, Paredes DA, Margittai M, Fortea J, Granholm AC. Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain. J Clin Med. 2021 Aug 31; 10(17). PMID: 34501378.
      View in: PubMed
    7. Grossberg AN, Bettcher BM, Gorgens KA, Ledreux A. Curiosity-Based Interventions Increase Everyday Functioning Score But Not Serum BDNF Levels in a Cohort of Healthy Older Adults. Front Aging. 2021; 2:700838. PMID: 35822037.
      View in: PubMed
    8. Lemoine L, Ledreux A, Mufson EJ, Perez SE, Simic G, Doran E, Lott I, Carroll S, Bharani K, Thomas S, Gilmore A, Hamlett ED, Nordberg A, Granholm AC. Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue. Mol Neurodegener. 2020 11 23; 15(1):68. PMID: 33222700.
      View in: PubMed
    9. Ledreux A, Pryhoda MK, Gorgens K, Shelburne K, Gilmore A, Linseman DA, Fleming H, Koza LA, Campbell J, Wolff A, Kelly JP, Margittai M, Davidson BS, Granholm AC. Assessment of Long-Term Effects of Sports-Related Concussions: Biological Mechanisms and Exosomal Biomarkers. Front Neurosci. 2020; 14:761. PMID: 32848549.
      View in: PubMed
    10. Wang Z, Fuquay JM, Ledreux A, Barbieri M, Ramsdell JS. Sample preparation and liquid chromatography-tandem mass spectrometry for the analysis of selected Pacific ciguatoxins in blood samples. J Chromatogr A. 2020 Jun 21; 1621:461050. PMID: 32265050.
      View in: PubMed
    11. Hamlett ED, Hjorth E, Ledreux A, Gilmore A, Schultzberg M, Granholm AC. RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome. Glia. 2020 07; 68(7):1347-1360. PMID: 31944407.
      View in: PubMed
    12. Bharani KL, Ledreux A, Gilmore A, Carroll SL, Granholm AC. Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease. Neurobiol Aging. 2020 03; 87:49-59. PMID: 31882186.
      View in: PubMed
    13. Hamlett ED, Ledreux A, Gilmore A, Vazey EM, Aston-Jones G, Boger HA, Paredes D, Granholm AE. Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome. Neurobiol Dis. 2020 02; 134:104616. PMID: 31678403.
      View in: PubMed
    14. Hamlett ED, LaRosa A, Mufson EJ, Fortea J, Ledreux A, Granholm AC. Exosome release and cargo in Down syndrome. Dev Neurobiol. 2019 07; 79(7):639-655. PMID: 31347291.
      View in: PubMed
    15. Goetzl EJ, Ledreux A, Granholm AC, Elahi FM, Goetzl L, Hiramoto J, Kapogiannis D. Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy. Front Neurosci. 2019; 13:452. PMID: 31133789.
      View in: PubMed
    16. Goetzl EJ, Elahi FM, Mustapic M, Kapogiannis D, Pryhoda M, Gilmore A, Gorgens KA, Davidson B, Granholm AC, Ledreux A. Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury. FASEB J. 2019 04; 33(4):5082-5088. PMID: 30605353.
      View in: PubMed
    17. Ledreux A, H?kansson K, Carlsson R, Kidane M, Columbo L, Terjestam Y, Ryan E, Tusch E, Winblad B, Daffner K, Granholm AC, Mohammed AKH. Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study. J Alzheimers Dis. 2019; 71(4):1245-1261. PMID: 31498125.
      View in: PubMed
    18. Bharani KL, Derex R, Granholm AC, Ledreux A. A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats. PLoS One. 2017; 12(12):e0189821. PMID: 29261743.
      View in: PubMed
    19. Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC. Exosomal biomarkers in Down syndrome and Alzheimer's disease. Free Radic Biol Med. 2018 01; 114:110-121. PMID: 28882786.
      View in: PubMed
    20. H?kansson K, Ledreux A, Daffner K, Terjestam Y, Bergman P, Carlsson R, Kivipelto M, Winblad B, Granholm AC, Mohammed AK. BDNF Responses in Healthy Older Persons?to 35 Minutes of Physical Exercise,?Cognitive Training, and?Mindfulness: Associations with?Working Memory Function. J Alzheimers Dis. 2017; 55(2):645-657. PMID: 27716670.
      View in: PubMed
    21. Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clark D, Carroll SL, Carmona-Iragui M, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, Lott IT, Granholm AC. Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome. Alzheimers Dement. 2017 May; 13(5):541-549. PMID: 27755974.
      View in: PubMed
    22. Ledreux A, Wang X, Schultzberg M, Granholm AC, Freeman LR. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behav Brain Res. 2016 10 01; 312:294-304. PMID: 27343935.
      View in: PubMed
    23. Rosenberger DS, Falangola MF, Ledreux A, Nie X, Suhre WM, Boger HA, Granholm AC. Memory and hippocampal architecture following short-term midazolam in western diet-treated rats. Neurosci Lett. 2016 05 16; 621:68-74. PMID: 27080429.
      View in: PubMed
    24. Hamlett ED, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AC. Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Curr Alzheimer Res. 2016; 13(1):35-52. PMID: 26391050.
      View in: PubMed
    25. Ledreux A, Boger HA, Hinson VK, Cantwell K, Granholm AC. BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson?s disease. Brain Res. 2016 Jan 15; 1631:34-45. PMID: 26607251.
      View in: PubMed
    26. Alvarenga LM, Muzard J, Ledreux A, Bernard C, Billiald P. Colorimetric engineered immunoprobe for the detection and quantification of microcystins. J Immunol Methods. 2014 Apr; 406:124-30. PMID: 24607607.
      View in: PubMed
    27. Ledreux A, Ramsdell JS. Bioavailability and intravenous toxicokinetic parameters for Pacific ciguatoxin P-CTX-1 in rats. Toxicon. 2013 Mar 15; 64:81-6. PMID: 23319077.
      View in: PubMed
    28. S?randour AL, Ledreux A, Morin B, Derick S, Augier E, Lanceleur R, Hamlaoui S, Moukha S, Furger C, Bir? R, Krys S, Fessard V, Troussellier M, Bernard C. Collaborative study for the detection of toxic compounds in shellfish extracts using cell-based assays. Part I: screening strategy and pre-validation study with lipophilic marine toxins. Anal Bioanal Chem. 2012 Jun; 403(7):1983-93. PMID: 22538779.
      View in: PubMed
    29. Ledreux A, S?randour AL, Morin B, Derick S, Lanceleur R, Hamlaoui S, Furger C, Bir? R, Krys S, Fessard V, Troussellier M, Bernard C. Collaborative study for the detection of toxic compounds in shellfish extracts using cell-based assays. Part II: application to shellfish extracts spiked with lipophilic marine toxins. Anal Bioanal Chem. 2012 Jun; 403(7):1995-2007. PMID: 22535441.
      View in: PubMed
    30. Ledreux A, Krys S, Bernard C. Suitability of the Neuro-2a cell line for the detection of palytoxin and analogues (neurotoxic phycotoxins). Toxicon. 2009 Feb; 53(2):300-8. PMID: 19100760.
      View in: PubMed
    31. Ar?oz R, Herdman M, Rippka R, Ledreux A, Molg? J, Changeux JP, Tandeau de Marsac N, Nghi?m HO. A non-radioactive ligand-binding assay for detection of cyanobacterial anatoxins using Torpedo electrocyte membranes. Toxicon. 2008 Jul; 52(1):163-74. PMID: 18617214.
      View in: PubMed
    32. Humpage AR, Ledreux A, Fanok S, Bernard C, Briand JF, Eaglesham G, Papageorgiou J, Nicholson B, Steffensen D. Application of the neuroblastoma assay for paralytic shellfish poisons to neurotoxic freshwater cyanobacteria: interlaboratory calibration and comparison with other methods of analysis. Environ Toxicol Chem. 2007 Jul; 26(7):1512-9. PMID: 17665694.
      View in: PubMed
    33. Gugger M, Lenoir S, Berger C, Ledreux A, Druart JC, Humbert JF, Guette C, Bernard C. First report in a river in France of the benthic cyanobacterium Phormidium favosum producing anatoxin-a associated with dog neurotoxicosis. Toxicon. 2005 Jun 01; 45(7):919-28. PMID: 15904687.
      View in: PubMed
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