Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Kayla Sprenger

TitleAssistant Professor
InstitutionUniversity of Colorado Boulder
DepartmentChemical & Biological Engin

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kitsu Iglesias L, Marks SD, Rampal N, Antonio EN, de Ferreira de Menezes R, Zhang L, Olds D, Weitzner SE, Sprenger KG, Wan LF, Toney MF. Microstructure-Dependent Sodium Storage Mechanisms in Hard Carbon Anodes. Small. 2025 May 29; e2505561. PMID: 40442960.
      View in: PubMed
    2. Lietzke EE, Saeb D, Aldrich EC, Bruce KD, Sprenger KG. Synergistic reduction in interfacial flexibility of TREM2R47H and ApoE4 may underlie AD pathology. Alzheimers Dement. 2025 Apr; 21(4):e70120. PMID: 40219843.
      View in: PubMed
    3. de Jesus GCC, Vasconcelos RDC, do Vale LB, de Menezes RF, Sprenger KG, Gargano R. Electronic and Magnetic Properties of Manganese Bromide Monolayers. Langmuir. 2025 Mar 11; 41(9):5877-5883. PMID: 39999295.
      View in: PubMed
    4. Kirby MB, Petersen BM, Faris JG, Kells SP, Sprenger KG, Whitehead TA. Retrospective SARS-CoV-2 human antibody development trajectories are largely sparse and permissive. Proc Natl Acad Sci U S A. 2025 Jan 28; 122(4):e2412787122. PMID: 39841142.
      View in: PubMed
    5. He R, McDonough L, Seitz L, Ou W, Marks SD, Ferreira de Menezes R, Allan-Cole E, Luo H, Toney MF, Sprenger KG, Zhou M, Tenent RC. In Situ Characterization of the Oxidation Behavior of Carbonate-Based Electrolytes for Lithium-Ion Batteries by Scanning Electrochemical Microscopy. ACS Electrochem. 2025 Apr 03; 1(4):494-503. PMID: 40201385.
      View in: PubMed
    6. Dong Z, Dunphy EE, Wegner AB, Medlin JW, Toney MF, Sprenger KG. An in Silico Investigation into Polyester Adsorption onto Alumina toward an Improved Understanding of Hydrogenolysis Catalysts. Langmuir. 2024 Dec 31; 40(52):27416-27429. PMID: 39567224.
      View in: PubMed
    7. Rhodes ER, Day NB, Aldrich EC, Wyatt Shields C, Sprenger KG. Elucidating the role of carrier proteins in cytokine stabilization within double emulsion-based polymeric nanoparticles. Bioeng Transl Med. 2025 Jan; 10(1):e10722. PMID: 39801762.
      View in: PubMed
    8. Fuchs DI, Serio LD, Balaji S, Sprenger KG. Investigating how HIV-1 antiretrovirals differentially behave as substrates and inhibitors of P-glycoprotein via molecular dynamics simulations. Comput Struct Biotechnol J. 2024 Dec; 23:2669-2679. PMID: 39027651.
      View in: PubMed
    9. Linda Zhong-Johnson EZ, Dong Z, Canova CT, Destro F, Ca?ellas M, Hoffman MC, Mar?chal J, Johnson TM, Zheng M, Schlau-Cohen GS, Lucas MF, Braatz RD, Sprenger KG, Voigt CA, Sinskey AJ. Correction: Analysis of Poly(ethylene terephthalate) degradation kinetics of evolved IsPETase variants using a surface crowding mode. J Biol Chem. 2024 Apr; 300(4):107240. PMID: 38579375.
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    10. Zhong-Johnson EZL, Dong Z, Canova CT, Destro F, Ca?ellas M, Hoffman MC, Mar?chal J, Johnson TM, Zheng M, Schlau-Cohen GS, Lucas MF, Braatz RD, Sprenger KG, Voigt CA, Sinskey AJ. Analysis of Poly(ethylene terephthalate) degradation kinetics of evolved IsPETase variants using a surface crowding model. J Biol Chem. 2024 03; 300(3):105783. PMID: 38395309.
      View in: PubMed
    11. Rhodes ER, Faris JG, Petersen BM, Sprenger KG. Common framework mutations impact antibody interfacial dynamics and flexibility. Front Immunol. 2023; 14:1120582. PMID: 36911727.
      View in: PubMed
    12. Faris JG, Orbidan D, Wells C, Petersen BK, Sprenger KG. Moving the needle: Employing deep reinforcement learning to push the boundaries of coarse-grained vaccine models. Front Immunol. 2022; 13:1029167. PMID: 36405722.
      View in: PubMed
    13. Oldham D, Wang H, Mullen J, Lietzke E, Sprenger K, Reigan P, Eckel RH, Bruce KD. Using Synthetic ApoC-II Peptides and nAngptl4 Fragments to Measure Lipoprotein Lipase Activity in Radiometric and Fluorescent Assays. Front Cardiovasc Med. 2022; 9:926631. PMID: 35911520.
      View in: PubMed
    14. Conti S, Ovchinnikov V, Faris JG, Chakraborty AK, Karplus M, Sprenger KG. Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV. PLoS Comput Biol. 2022 04; 18(4):e1009391. PMID: 35442968.
      View in: PubMed
    15. Sprenger K, Roeters SJ, Mauri S, Mertig R, Nishiyama Y, Pfaendtner J, Weidner T. Direct Evidence for Aligned Binding of Cellulase Enzymes to Cellulose Surfaces. J Phys Chem Lett. 2021 Nov 04; 12(43):10684-10688. PMID: 34709817.
      View in: PubMed
    16. Petersen BM, Ulmer SA, Rhodes ER, Gutierrez-Gonzalez MF, Dekosky BJ, Sprenger KG, Whitehead TA. Regulatory Approved Monoclonal Antibodies Contain Framework Mutations Predicted From Human Antibody Repertoires. Front Immunol. 2021; 12:728694. PMID: 34646268.
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    17. Francino-Urdaniz IM, Steiner PJ, Kirby MB, Zhao F, Haas CM, Barman S, Rhodes ER, Leonard AC, Peng L, Sprenger KG, Jardine JG, Whitehead TA. One-shot identification of SARS-CoV-2?S RBD escape mutants using yeast screening. Cell Rep. 2021 08 31; 36(9):109627. PMID: 34416153.
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    18. Urdaniz IF, Steiner PJ, Kirby MB, Zhao F, Haas CM, Barman S, Rhodes ER, Peng L, Sprenger KG, Jardine JG, Whitehead TA. One-shot identification of SARS-CoV-2 S RBD escape mutants using yeast screening. bioRxiv. 2021 Mar 15. PMID: 33758848.
      View in: PubMed
    19. Sprenger KG, Louveau JE, Murugan PM, Chakraborty AK. Optimizing immunization protocols to elicit broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):20077-20087. PMID: 32747563.
      View in: PubMed
    20. Hellner B, Alamdari S, Pyles H, Zhang S, Prakash A, Sprenger KG, De Yoreo JJ, Baker D, Pfaendtner J, Baneyx F. Sequence-Structure-Binding Relationships Reveal Adhesion Behavior of the Car9 Solid-Binding Peptide: An Integrated Experimental and Simulation Study. J Am Chem Soc. 2020 02 05; 142(5):2355-2363. PMID: 31934768.
      View in: PubMed
    21. Mao CM, Sampath J, Sprenger KG, Drobny G, Pfaendtner J. Molecular Driving Forces in Peptide Adsorption to Metal Oxide Surfaces. Langmuir. 2019 04 30; 35(17):5911-5920. PMID: 30955325.
      View in: PubMed
    22. Oleson KR, Sprenger KG, Pfaendtner J, Schwartz DT. Inhibition of the Exoglucanase Cel7A by a Douglas-Fir-Condensed Tannin. J Phys Chem B. 2018 09 20; 122(37):8665-8674. PMID: 30111095.
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    23. Summers SR, Sprenger KG, Pfaendtner J, Marchant J, Summers MF, Kaar JL. Mechanism of Competitive Inhibition and Destabilization of Acidothermus cellulolyticus Endoglucanase 1 by Ionic Liquids. J Phys Chem B. 2017 12 07; 121(48):10793-10803. PMID: 29120187.
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    24. Sprenger KG, Prakash A, Drobny G, Pfaendtner J. Investigating the Role of Phosphorylation in the Binding of Silaffin Peptide R5 to Silica with Molecular Dynamics Simulations. Langmuir. 2018 01 23; 34(3):1199-1207. PMID: 28981294.
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    25. Prakash A, Sprenger KG, Pfaendtner J. Essential slow degrees of freedom in protein-surface simulations: A metadynamics investigation. Biochem Biophys Res Commun. 2018 03 29; 498(2):274-281. PMID: 28720500.
      View in: PubMed
    26. Sprenger KG, Plaks JG, Kaar JL, Pfaendtner J. Elucidating sequence and solvent specific design targets to protect and stabilize enzymes for biocatalysis in ionic liquids. Phys Chem Chem Phys. 2017 Jul 05; 19(26):17426-17433. PMID: 28650512.
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    27. Smith J, Sprenger KG, Liao R, Joseph A, Nance E, Pfaendtner J. Determining dominant driving forces affecting controlled protein release from polymeric nanoparticles. Biointerphases. 2017 05 19; 12(2):02D412. PMID: 28525957.
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    28. Sprenger KG, Pfaendtner J. Using Molecular Simulation to Study Biocatalysis in Ionic Liquids. Methods Enzymol. 2016; 577:419-41. PMID: 27498647.
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    29. Sprenger KG, Pfaendtner J. Strong Electrostatic Interactions Lead to Entropically Favorable Binding of Peptides to Charged Surfaces. Langmuir. 2016 06 07; 32(22):5690-701. PMID: 27181161.
      View in: PubMed
    30. Sprenger KG, Choudhury A, Kaar JL, Pfaendtner J. Lytic Polysaccharide Monooxygenases ScLPMO10B and ScLPMO10C Are Stable in Ionic Liquids As Determined by Molecular Simulations. J Phys Chem B. 2016 04 28; 120(16):3863-72. PMID: 27052057.
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    31. Sprenger KG, Jaeger VW, Pfaendtner J. The general AMBER force field (GAFF) can accurately predict thermodynamic and transport properties of many ionic liquids. J Phys Chem B. 2015 May 07; 119(18):5882-95. PMID: 25853313.
      View in: PubMed
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