Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Daniel R Ambruso

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/363-2240

    Collapse Research 
    Collapse research activities and funding
    R01AI019423     (AMBRUSO, DANIEL R)Dec 1, 1983 - Mar 31, 1987
    NIH/NIAID
    HYDROXYL RADICAL AND BACTERIAL KILLING BY NEUTROPHILS
    Role: Principal Investigator

    F06TW001357     (AMBRUSO, DANIEL R)Nov 15, 1988
    NIH/FIC
    CHARACTERIZATION OF BIOCHEMICAL DEFECT IN AUTOSOMAL CGD
    Role: Principal Investigator

    K07HL002036     (AMBRUSO, DANIEL R)Jul 1, 1990 - Jun 30, 1995
    NIH/NHLBI
    TRANSFUSION MEDICINE ACADEMIC AWARD
    Role: Principal Investigator

    K07HL088968     (AMBRUSO, DANIEL R)Jul 19, 2007 - May 31, 2013
    NIH/NHLBI
    Program in Pediatric Transfusion Medicine
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kwon J, Wang A, Burke DJ, Boudreau HE, Lekstrom KJ, Korzeniowska A, Sugamata R, Kim YS, Yi L, Ersoy I, Jaeger S, Palaniappan K, Ambruso DR, Jackson SH, Leto TL. Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration. Free Radic Biol Med. 2016 Jul; 96:99-115. PMID: 27094494.
      View in: PubMed
    2. Ellison MA, Thurman G, Gearheart CM, Seewald RH, Porter CC, Ambruso DR. INF-? Enhances Nox2 Activity by Upregulating phox Proteins When Applied to Differentiating PLB-985 Cells but Does Not Induce Nox2 Activity by Itself. PLoS One. 2015; 10(8):e0136766. PMID: 26317224.
      View in: PubMed
    3. McKinney CM, Siringo F, Olson JL, Capocelli KE, Ambruso DR, Nuss R. Red cell exchange transfusion halts progressive proliferative sickle cell retinopathy in a teenaged patient with hemoglobin SC disease. Pediatr Blood Cancer. 2015 Apr; 62(4):721-3. PMID: 25631233.
      View in: PubMed
    4. Ballen KK, Logan BR, Laughlin MJ, He W, Ambruso DR, Armitage SE, Beddard RL, Bhatla D, Hwang WY, Kiss JE, Koegler G, Kurtzberg J, Nagler A, Oh D, Petz LD, Price TH, Quinones RR, Ratanatharathorn V, Rizzo JD, Sazama K, Scaradavou A, Schuster MW, Sender LS, Shpall EJ, Spellman SR, Sutton M, Weitekamp LA, Wingard JR, Eapen M. Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation. Biol Blood Marrow Transplant. 2015 Apr; 21(4):688-95. PMID: 25543094.
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    5. Cancelas JA, Padmanabhan A, Le T, Ambruso DR, Rugg N, Worsham DN, Pinkard SL, Graminske S, Buck J, Goldberg J, Bill J. Spectra Optia granulocyte apheresis collections result in higher collection efficiency of viable, functional neutrophils in a randomized, crossover, multicenter trial. Transfusion. 2015 Apr; 55(4):748-55. PMID: 25382805.
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    6. Ambruso DR. Hydroxyethyl starch and granulocyte transfusions: considerations of utility and toxicity profile for patients and donors. Transfusion. 2015 Apr; 55(4):911-8. PMID: 25315227.
      View in: PubMed
    7. Josephson CD, Mondoro TH, Ambruso DR, Sanchez R, Sloan SR, Luban NL, Widness JA. One size will never fit all: the future of research in pediatric transfusion medicine. Pediatr Res. 2014 Nov; 76(5):425-31. PMID: 25119336.
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    8. Ambruso DR. Transfusion complications in thalassemias. Transfusion. 2014 Apr; 54(4):957-9. PMID: 24724786.
      View in: PubMed
    9. Maloney JP, Ambruso DR, Voelkel NF, Silliman CC. Platelet Vascular Endothelial Growth Factor is a Potential Mediator of Transfusion-Related Acute Lung Injury. J Pulm Respir Med. 2014; 4. PMID: 25705568.
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    10. Dzieciatkowska M, Silliman CC, Moore EE, Kelher MR, Banerjee A, Land KJ, Ellison M, West FB, Ambruso DR, Hansen KC. Proteomic analysis of the supernatant of red blood cell units: the effects of storage and leucoreduction. Vox Sang. 2013 Oct; 105(3):210-8. PMID: 23663258.
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    11. Bercovitz RS, Macy M, Ambruso DR. A case of autoimmune hemolytic anemia with anti-D specificity in a 1-year-old child. Immunohematology. 2013; 29(1):15-8. PMID: 24046918.
      View in: PubMed
    12. Ambruso DR. Peroxiredoxin-6 and NADPH oxidase activity. Methods Enzymol. 2013; 527:145-67. PMID: 23830630.
      View in: PubMed
    13. Knipstein JA, Ambruso DR. Sweet syndrome in an infant with chronic granulomatous disease. J Pediatr Hematol Oncol. 2012 Jul; 34(5):372-4. PMID: 22246153.
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    14. Ellison MA, Thurman GW, Ambruso DR. Phox activity of differentiated PLB-985 cells is enhanced, in an agonist specific manner, by the PLA2 activity of Prdx6-PLA2. Eur J Immunol. 2012 Jun; 42(6):1609-17. PMID: 22678913.
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    15. Silliman CC, Kelher M, Ambruso DR. Bioactive lipids from stored cellular blood components: in vitro method is crucial for proper interpretation. Transfusion. 2012 May; 52(5):1155-7; author reply 1157-8. PMID: 22571364.
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    16. Ambruso DR, Sanchez R, Sloan SR, Josephson CD. How do we teach pediatric topics in transfusion medicine: curriculum development, learners, and instructional strategies. Transfusion. 2013 Feb; 53(2):250-6. PMID: 22519665.
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    17. Reesink HW, Lee J, Keller A, Dennington P, Pink J, Holdsworth R, Schennach H, Goldman M, Petraszko T, Sun J, Meng Y, Qian K, Rehacek V, Turek P, Krusius T, Juvonen E, Tiberghien P, Legrand D, Semana G, Muller JY, Bux J, Reil A, Lin CK, Daly H, McSweeney E, Porretti L, Greppi N, Rebulla P, Okazaki H, Sánchez-Guerrero SA, Baptista-González HA, Martínez-Murillo C, Guerra-Márquez A, Rodriguez-Moyado H, Middelburg RA, Wiersum-Osselton JC, Brand A, van Tilburg C, Dinesh D, Dagger J, Dunn P, Brojer E, Letowska M, Maslanka K, Lachert E, Uhrynowska M, Zhiburt E, Palfi M, Berlin G, Frey BM, Puig Rovira L, Muñiz-Diaz E, Castro E, Chapman C, Green A, Massey E, Win N, Williamson L, Silliman CC, Chaffin DJ, Ambruso DR, Blumberg N, Tomasulo P, Land KJ, Norris PJ, Illoh OC, Davey RJ, Benjamin RJ, Eder AF, McLaughlin L, Kleinman S, Panzer S. Measures to prevent transfusion-related acute lung injury (TRALI). Vox Sang. 2012 Oct; 103(3):231-59. PMID: 22519920.
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    18. Ellison MA, Ambruso DR, Silliman CC. Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor. Curr Pharm Des. 2012; 18(22):3255-9. PMID: 22621271.
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    19. Ambruso DR, Ellison MA, Thurman GW, Leto TL. Peroxiredoxin 6 translocates to the plasma membrane during neutrophil activation and is required for optimal NADPH oxidase activity. Biochim Biophys Acta. 2012 Feb; 1823(2):306-15. PMID: 22178385.
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    20. Lasalle-Williams M, Nuss R, Le T, Cole L, Hassell K, Murphy JR, Ambruso DR. Extended red blood cell antigen matching for transfusions in sickle cell disease: a review of a 14-year experience from a single center (CME). Transfusion. 2011 Aug; 51(8):1732-9. PMID: 21332724.
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    21. Alsultan A, Sokol RJ, Lovell MA, Thurman G, Ambruso DR. Long term G-CSF-induced remission of ulcerative colitis-like inflammatory bowel disease in a patient with glycogen storage disease Ib and evaluation of associated neutrophil function. Pediatr Blood Cancer. 2010 Dec 15; 55(7):1410-3. PMID: 20830779.
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    22. Ambruso DR, Thurman G, Tran K, Marschner S, Gathof B, Janetzko K, Goodrich RP. Generation of neutrophil priming activity by cell-containing blood components treated with pathogen reduction technology and stored in platelet additive solutions. Transfusion. 2011 Jun; 51(6):1220-7. PMID: 21155831.
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    23. Sanchez R, Sloan SR, Josephson CD, Ambruso DR, Hillyer CD, O'Sullivan P. Consensus recommendations of pediatric transfusion medicine objectives for clinical pathology residency training programs. Transfusion. 2010 May; 50(5):1071-8. PMID: 20051052.
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    24. Ambruso DR, Thurman G, Marschner S, Goodrich RP. Lack of antibody formation to platelet neoantigens after transfusion of riboflavin and ultraviolet light-treated platelet concentrates. Transfusion. 2009 Dec; 49(12):2631-6. PMID: 19694996.
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    25. Rael LT, Bar-Or R, Ambruso DR, Mains CW, Slone DS, Craun ML, Bar-Or D. Phthalate esters used as plasticizers in packed red blood cell storage bags may lead to progressive toxin exposure and the release of pro-inflammatory cytokines. Oxid Med Cell Longev. 2009 Jul-Aug; 2(3):166-71. PMID: 20592772.
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    26. Rael LT, Bar-Or R, Ambruso DR, Mains CW, Slone DS, Craun ML, Bar-Or D. The effect of storage on the accumulation of oxidative biomarkers in donated packed red blood cells. J Trauma. 2009 Jan; 66(1):76-81. PMID: 19131808.
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    27. Heath S, Higgs J, Ambruso DR. Evidence of knowledge acquisition in a cognitive flexibility-based computer learning environment. Med Educ Online. 2008 Dec 03; 13:16. PMID: 20165544.
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    28. Hillyer CD, Mondoro TH, Josephson CD, Sanchez R, Sloan SR, Ambruso DR. Pediatric transfusion medicine: development of a critical mass. Transfusion. 2009 Mar; 49(3):596-601. PMID: 19040410.
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    29. Brown JA, Factor DL, Tkachenko N, Templeton SM, Crall ND, Pape WJ, Bauer MJ, Ambruso DR, Dickey WC, Marfin AA. West Nile viremic blood donors and risk factors for subsequent West Nile fever. Vector Borne Zoonotic Dis. 2007; 7(4):479-88. PMID: 17979539.
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    30. Silliman CC, Curtis BR, Kopko PM, Khan SY, Kelher MR, Schuller RM, Sannoh B, Ambruso DR. Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model. Blood. 2007 Feb 15; 109(4):1752-5. PMID: 17038531.
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    31. Wang M, Hays T, Ambruso DR, Silliman CC, Dickey WC. Hemolytic disease of the newborn caused by a high titer anti-group B IgG from a group A mother. Pediatr Blood Cancer. 2005 Nov; 45(6):861-2. PMID: 16007582.
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    32. Chudgar UH, Thurman GW, Ambruso DR. Oxidase activity in cord blood neutrophils: a balance between increased membrane associated cytochrome b558 and deficient cytosolic components. Pediatr Blood Cancer. 2005 Sep; 45(3):311-7. PMID: 15700257.
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    33. Toy P, Popovsky MA, Abraham E, Ambruso DR, Holness LG, Kopko PM, McFarland JG, Nathens AB, Silliman CC, Stroncek D. Transfusion-related acute lung injury: definition and review. Crit Care Med. 2005 Apr; 33(4):721-6. PMID: 15818095.
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    34. Silliman CC, Ambruso DR, Boshkov LK. Transfusion-related acute lung injury. Blood. 2005 Mar 15; 105(6):2266-73. PMID: 15572582.
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    35. Covin RB, Ambruso DR, England KM, Kelher MR, Mehdizadehkashi Z, Boshkov LK, Masuno T, Moore EE, Kim FJ, Silliman CC. Hypotension and acute pulmonary insufficiency following transfusion of autologous red blood cells during surgery: a case report and review of the literature. Transfus Med. 2004 Oct; 14(5):375-83. PMID: 15500457.
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    36. Anderson MS, Knall C, Thurman G, Mann D, Cusack N, Johnson GL, Ambruso DR. CP-64131, an aminobenzazepine with cytokine-like properties, stimulates human neutrophil functions through the p38-MAPK pathway. J Leukoc Biol. 2004 Aug; 76(2):477-83. PMID: 15155776.
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    37. Ambruso DR, Cusack N, Thurman G. NADPH oxidase activity of neutrophil specific granules: requirements for cytosolic components and evidence of assembly during cell activation. Mol Genet Metab. 2004 Apr; 81(4):313-21. PMID: 15059619.
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    38. Abell AN, DeCathelineau AM, Weed SA, Ambruso DR, Riches DW, Johnson GL. Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages. J Cell Sci. 2004 Jan 15; 117(Pt 2):243-55. PMID: 14676277.
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    39. Kelher MR, Ambruso DR, Elzi DJ, Anderson SM, Paterson AJ, Thurman GW, Silliman CC. Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophils. Cell Calcium. 2003 Dec; 34(6):445-55. PMID: 14572803.
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    40. Silliman CC, Elzi DJ, Ambruso DR, Musters RJ, Hamiel C, Harbeck RJ, Paterson AJ, Bjornsen AJ, Wyman TH, Kelher M, England KM, McLaughlin-Malaxecheberria N, Barnett CC, Aiboshi J, Bannerjee A. Lysophosphatidylcholines prime the NADPH oxidase and stimulate multiple neutrophil functions through changes in cytosolic calcium. J Leukoc Biol. 2003 Apr; 73(4):511-24. PMID: 12660226.
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    41. Ballen KK, Hicks J, Dharan B, Ambruso D, Anderson K, Bianco C, Bemiller L, Dickey W, Lottenberg R, O'Neill M, Popovsky M, Skerrett D, Sniecinski I, Wingard JR. Racial and ethnic composition of volunteer cord blood donors: comparison with volunteer unrelated marrow donors. Transfusion. 2002 Oct; 42(10):1279-84. PMID: 12423511.
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    42. Silliman CC, Boshkov LK, Mehdizadehkashi Z, Elzi DJ, Dickey WO, Podlosky L, Clarke G, Ambruso DR. Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors. Blood. 2003 Jan 15; 101(2):454-62. PMID: 12393667.
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    43. Leavey PJ, Gonzalez-Aller C, Thurman G, Kleinberg M, Rinckel L, Ambruso DW, Freeman S, Kuypers FA, Ambruso DR. A 29-kDa protein associated with p67phox expresses both peroxiredoxin and phospholipase A2 activity and enhances superoxide anion production by a cell-free system of NADPH oxidase activity. J Biol Chem. 2002 Nov 22; 277(47):45181-7. PMID: 12121978.
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    44. Fleitz J, Rumelhart S, Goldman F, Ambruso D, Sokol RJ, Pacini D, Quinones R, Holida M, Lee N, Tannous R, Giller R. Successful allogeneic hematopoietic stem cell transplantation (HSCT) for Shwachman-Diamond syndrome. Bone Marrow Transplant. 2002 Jan; 29(1):75-9. PMID: 11840149.
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    45. Zimbelman J, Thurman G, Leavey PJ, Ellison MC, Ambruso DR. In vivo treatment with granulocyte colony-stimulating factor does not delay apoptosis in human neutrophils by increasing the expression of the vacuolar proton ATPase. J Investig Med. 2002 Jan; 50(1):33-7. PMID: 11813826.
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    46. Gardai S, Whitlock BB, Helgason C, Ambruso D, Fadok V, Bratton D, Henson PM. Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils. J Biol Chem. 2002 Feb 15; 277(7):5236-46. PMID: 11724799.
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    47. Kurkchubasche AG, Panepinto JA, Tracy TF, Thurman GW, Ambruso DR. Clinical features of a human Rac2 mutation: a complex neutrophil dysfunction disease. J Pediatr. 2001 Jul; 139(1):141-7. PMID: 11445809.
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    48. Dumont LJ, Luka J, VandenBroeke T, Whitley P, Ambruso DR, Elfath MD. The effect of leukocyte-reduction method on the amount of human cytomegalovirus in blood products: a comparison of apheresis and filtration methods. Blood. 2001 Jun 01; 97(11):3640-7. PMID: 11369662.
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    49. Williams DA, Tao W, Yang F, Kim C, Gu Y, Mansfield P, Levine JE, Petryniak B, Derrow CW, Harris C, Jia B, Zheng Y, Ambruso DR, Lowe JB, Atkinson SJ, Dinauer MC, Boxer L. Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. Blood. 2000 Sep 01; 96(5):1646-54. PMID: 10961859.
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    50. Zimbelman J, Silliman CC, Ambruso DR. Transfusion-related acute lung injury and granulocytes from stored packed RBCs. Transfusion. 2000 May; 40(5):614-5. PMID: 10827271.
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    51. Ambruso DR, Knall C, Abell AN, Panepinto J, Kurkchubasche A, Thurman G, Gonzalez-Aller C, Hiester A, deBoer M, Harbeck RJ, Oyer R, Johnson GL, Roos D. Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4654-9. PMID: 10758162.
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    52. Leavey PJ, Thurman G, Ambruso DR. Functional characteristics of neutrophils collected and stored after administration of G-CSF. Transfusion. 2000 Apr; 40(4):414-9. PMID: 10773052.
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    53. Schooley RT, Mladenovic J, Sevin A, Chiu S, Miles SA, Pomerantz RJ, Campbell TB, Bell D, Ambruso D, Wong R, Landay A, Coombs RW, Fox L, Kamoun M, Jacovini J. Reduced mobilization of CD34+ stem cells in advanced human immunodeficiency virus type 1 disease. J Infect Dis. 2000 Jan; 181(1):148-57. PMID: 10608761.
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    54. Campbell TB, Sevin A, Coombs RW, Peterson GC, Rosandich M, Kuritzkes DR, Mladenovic J, Landay A, Wong R, Ambruso D, Miles S, Pomerantz RJ, Schooley RT. Changes in human immunodeficiency virus type 1 virus load during mobilization and harvesting of hemopoietic progenitor cells. Adult AIDS Clinical Trials Group 285 Study Team. Blood. 2000 Jan 01; 95(1):48-55. PMID: 10607683.
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    55. Leavey PJ, Sellins KS, Thurman G, Elzi D, Hiester A, Silliman CC, Zerbe G, Cohen JJ, Ambruso DR. In vivo treatment with granulocyte colony-stimulating factor results in divergent effects on neutrophil functions measured in vitro. Blood. 1998 Dec 01; 92(11):4366-74. PMID: 9834243.
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    56. Maloney JP, Silliman CC, Ambruso DR, Wang J, Tuder RM, Voelkel NF. In vitro release of vascular endothelial growth factor during platelet aggregation. Am J Physiol. 1998 Sep; 275(3 Pt 2):H1054-61. PMID: 9724313.
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    57. Leavey PJ, Thurman G, Gonzalez-Aller C, Zerbe G, Ambruso DR. The effects of stem cell factor and granulocyte colony stimulating factor therapy on the activity of the neutrophil NADPH oxidase enzyme system. J Investig Med. 1998 Apr; 46(4):121-6. PMID: 9635370.
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    58. Silliman CC, Voelkel NF, Allard JD, Elzi DJ, Tuder RM, Johnson JL, Ambruso DR. Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model. J Clin Invest. 1998 Apr 01; 101(7):1458-67. PMID: 9525989.
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    59. Hayward A, Ambruso D, Battaglia F, Donlon T, Eddelman K, Giller R, Hobbins J, Hsia YE, Quinones R, Shpall E, Trachtenberg E, Giardina P. Microchimerism and tolerance following intrauterine transplantation and transfusion for alpha-thalassemia-1. Fetal Diagn Ther. 1998 Jan-Feb; 13(1):8-14. PMID: 9605609.
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    60. Wang R, Shattil SJ, Ambruso DR, Newman PJ. Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex. J Clin Invest. 1997 Nov 01; 100(9):2393-403. PMID: 9351872.
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    61. Silliman CC, Paterson AJ, Dickey WO, Stroneck DF, Popovsky MA, Caldwell SA, Ambruso DR. The association of biologically active lipids with the development of transfusion-related acute lung injury: a retrospective study. Transfusion. 1997 Jul; 37(7):719-26. PMID: 9225936.
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    62. Rosenthal J, Thurman GW, Cusack N, Peterson VM, Malech HL, Ambruso DR. Neutrophils from patients after burn injury express a deficiency of the oxidase components p47-phox and p67-phox. Blood. 1996 Dec 01; 88(11):4321-9. PMID: 8943869.
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    63. Silliman CC, Dickey WO, Paterson AJ, Thurman GW, Clay KL, Johnson CA, Ambruso DR. Analysis of the priming activity of lipids generated during routine storage of platelet concentrates. Transfusion. 1996 Feb; 36(2):133-9. PMID: 8614963.
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    64. Silliman CC, Cusack NA, Swanson NJ, Ghaffarifar S, Ambruso DR. Platelets and neutrophils from healthy term neonates exhibit increased levels of immunoglobulins. Pediatr Res. 1995 Dec; 38(6):993-7. PMID: 8618806.
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    65. Silliman CC, Clay KL, Thurman GW, Johnson CA, Ambruso DR. Partial characterization of lipids that develop during the routine storage of blood and prime the neutrophil NADPH oxidase. J Lab Clin Med. 1994 Nov; 124(5):684-94. PMID: 7964126.
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    66. Lombardo JF, Cusack NA, Rajagopalan C, Sangaline RJ, Ambruso DR. Flow cytometric analysis of residual white blood cell concentration and platelet activation antigens in double filtered platelet concentrates. J Lab Clin Med. 1993 Nov; 122(5):557-66. PMID: 8228574.
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    67. Silliman CC, Johnson CA, Clay KL, Thurman GW, Ambruso DR. Compounds biologically similar to platelet activating factor are present in stored blood components. Lipids. 1993 May; 28(5):415-8. PMID: 8316049.
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    68. Herr V, Ambruso D, Fairfax M, Neumann A, Swanson P, Lee H. Transfusion-associated transmission of human T-lymphotropic virus types I and II: experience of a regional blood center. Transfusion. 1993 Mar; 33(3):208-11. PMID: 8438220.
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    69. Silliman CC, Thurman GW, Ambruso DR. Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor. Vox Sang. 1992; 63(2):133-6. PMID: 1332255.
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    70. Pitman JM, Thurman GW, Anderson BO, Ketch LL, Hartford CE, Harken AH, Ambruso DR. WEB2170, a specific platelet-activating factor antagonist, attenuates neutrophil priming by human serum after clinical burn injury: the 1991 Moyer Award. J Burn Care Rehabil. 1991 Sep-Oct; 12(5):411-9. PMID: 1661287.
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    71. Burkhart KK, Kulig KW, Hammond KB, Pearson JR, Ambruso D, Rumack B. The rise in the total iron-binding capacity after iron overdose. Ann Emerg Med. 1991 May; 20(5):532-5. PMID: 2024794.
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    72. Goldman F, Rotbart H, Gutierrez K, Ambruso D. Parvovirus-associated aplastic crisis in a patient with red blood cell glucose-6-phosphate dehydrogenase deficiency. Pediatr Infect Dis J. 1990 Aug; 9(8):593-4. PMID: 2172909.
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    73. Eaton SS, Dubach J, Eaton GR, Thurman G, Ambruso DR. Electron spin echo envelope modulation evidence for carbonate binding to iron(III) and copper(II) transferrin and lactoferrin. J Biol Chem. 1990 May 05; 265(13):7138-41. PMID: 2158987.
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    74. Ambruso DR, Bolscher BG, Stokman PM, Verhoeven AJ, Roos D. Assembly and activation of the NADPH:O2 oxidoreductase in human neutrophils after stimulation with phorbol myristate acetate. J Biol Chem. 1990 Jan 15; 265(2):924-30. PMID: 2153119.
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    75. Smith TJ, Gill JC, Ambruso DR, Hathaway WE. Hyponatremia and seizures in young children given DDAVP. Am J Hematol. 1989 Jul; 31(3):199-202. PMID: 2500851.
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    76. Gordon GS, Ambruso DR, Robinson WA, Githens JH. Intranasal administration of deferoxamine to iron overloaded patients. Am J Med Sci. 1989 May; 297(5):280-4. PMID: 2640419.
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    77. Eaton SS, Dubach J, More KM, Eaton GR, Thurman G, Ambruso DR. Comparison of the electron spin echo envelope modulation (ESEEM) for human lactoferrin and transferrin complexes of copper(II) and vanadyl ion. J Biol Chem. 1989 Mar 25; 264(9):4776-81. PMID: 2538460.
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    78. Peterson VM, Ambruso DR, Emmett M, Bartle EJ. Inhibition of colony-stimulating factor (CSF) production by postburn serum: negative feedback inhibition mediated by lactoferrin. J Trauma. 1988 Nov; 28(11):1533-40. PMID: 3263509.
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    79. Mahoney DH, Ambruso DR, McCabe ER, Anderson DC, Leonard JV, Dunger DB. Lack of effect of lithium carbonate in patients with glycogenosis Ib. Am J Dis Child. 1987 Sep; 141(9):985-6. PMID: 3113232.
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    80. Ambruso DR, Stork LC, Gibson BE, Thurman GW. Increased activity of the respiratory burst in cord blood neutrophils: kinetics of the NADPH oxidase enzyme system in subcellular fractions. Pediatr Res. 1987 Feb; 21(2):205-10. PMID: 3029658.
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    81. Ambruso DR, Githens JH, Alcorn R, Dixon DJ, Brown LJ, Vaughn WM, Hays T. Experience with donors matched for minor blood group antigens in patients with sickle cell anemia who are receiving chronic transfusion therapy. Transfusion. 1987 Jan-Feb; 27(1):94-8. PMID: 3810834.
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    82. Sasada M, Kubo A, Nishimura T, Kakita T, Moriguchi T, Uchino H, Ambruso DR, Johnston RB. NADPH-dependent antibacterial activity in subcellular fractions of human neutrophils: interaction with granule constituents. Nihon Ketsueki Gakkai Zasshi. 1986 Sep; 49(6):1152-63. PMID: 3811782.
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    83. Stork LC, Ambruso DR, Wallner SF, Sambrano JE, Moscinski LC, Wilson HL, McCabe ER. Pancytopenia in propionic acidemia: hematologic evaluation and studies of hematopoiesis in vitro. Pediatr Res. 1986 Aug; 20(8):783-8. PMID: 3737292.
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    84. Ambruso DR, Hawkins B, Johnson DL, Fritzberg AR, Klingensmith WC, McCabe ER. Measurement of adenosine triphosphate and 2,3-diphosphoglycerate in stored blood with 31P nuclear magnetic resonance spectroscopy. Biochem Med Metab Biol. 1986 Jun; 35(3):376-83. PMID: 3718767.
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    85. Speer CP, Ambruso DR, Grimsley J, Johnston RB. Oxidative metabolism in cord blood monocytes and monocyte-derived macrophages. Infect Immun. 1985 Dec; 50(3):919-21. PMID: 2999001.
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    86. Sokol RJ, Francis PD, Gold SH, Ford DM, Lum GM, Ambruso DR. Orthotopic liver transplantation for acute fulminant Wilson disease. J Pediatr. 1985 Oct; 107(4):549-52. PMID: 3900322.
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    87. Ambruso DR, McCabe ER, Anderson D, Beaudet A, Ballas LM, Brandt IK, Brown B, Coleman R, Dunger DB, Falletta JM, et al. Infectious and bleeding complications in patients with glycogenosis Ib. Am J Dis Child. 1985 Jul; 139(7):691-7. PMID: 3860000.
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    88. Hambidge KM, Norris DA, Githens JH, Ambruso D, Catalanotto FA. Hyperzincemia in a patient with pyoderma gangrenosum. J Pediatr. 1985 Mar; 106(3):450-1. PMID: 3973783.
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    89. Ambruso DR, Bentwood B, Henson PM, Johnston RB. Oxidative metabolism of cord blood neutrophils: relationship to content and degranulation of cytoplasmic granules. Pediatr Res. 1984 Nov; 18(11):1148-53. PMID: 6096799.
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    90. Ambruso DR, Sasada M, Nishiyama H, Kubo A, Komiyama A, Allen RH. Defective bactericidal activity and absence of specific granules in neutrophils from a patient with recurrent bacterial infections. J Clin Immunol. 1984 Jan; 4(1):23-30. PMID: 6321538.
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    91. Hayward AR, Githens J, Murphy S, McWilliams B, Lane P, Ambruso DR. Delayed marrow aplasia following treatment for thymic hypoplasia: correction by marrow transplant without immunosuppression. Birth Defects Orig Artic Ser. 1983; 19(3):277-9. PMID: 6360240.
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    92. Ambruso DR, Leonard BD, Bies RD, Jacobson L, Hathaway WE, Reeve EB. Antithrombin III deficiency: decreased synthesis of a biochemically normal molecule. Blood. 1982 Jul; 60(1):78-83. PMID: 7082848.
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    93. Hayward AR, Murphy S, Githens J, Troup G, Ambruso D. Failure of a pan-reactive anti-T cell antibody, OKT 3, to prevent graft versus host disease in severe combined immunodeficiency. J Pediatr. 1982 Apr; 100(4):665-8. PMID: 7038081.
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    94. Ambruso DR, Mahony BS, Githens JH, Rhoades ED. Effect of subcutaneous deferoxamine and oral vitamin C on iron excretion in congenital hypoplastic anemia and refractory anemia associated with the 5q-syndrome. Am J Pediatr Hematol Oncol. 1982; 4(2):115-23. PMID: 7114394.
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    95. Ambruso DR, Johnston RB. Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil particulate fractions, and an enzymatic generating system. J Clin Invest. 1981 Feb; 67(2):352-60. PMID: 6780607.
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    96. Ambruso DR, Hays T, Zwartjes WJ, Tubergen DG, Favara BE. Successful treatment of lymphohistiocytic reticulosis with phagocytosis with epipodophyllotoxin VP 16-213. Cancer. 1980 May 15; 45(10):2516-20. PMID: 7378987.
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    97. Ambruso DR, Jacobson LJ, Hathaway WE. Inherited antithrombin III deficiency and cerebral thrombosis in a child. Pediatrics. 1980 Jan; 65(1):125-31. PMID: 7355006.
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    98. Ambruso DR, Altenburger KM, Johnston RB. Defective oxidative metabolism in newborn neutrophils: discrepancy between superoxide anion and hydroxyl radical generation. Pediatrics. 1979 Nov; 64(5 Pt 2 Suppl):722-5. PMID: 228239.
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    99. Mahony BS, Ambruso DR, Githens JH. Iron studies in sickle cell anemia. J Pediatr. 1978 Dec; 93(6):1070. PMID: 722435.
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    100. Ambruso DR, Durante DP, McIntosh RM, Hathaway WE. Factor VIII and renal disease. Ann Intern Med. 1977 Nov; 87(5):636-7. PMID: 921104.
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    101. Mokrohisky ST, Ambruso DR, Hathaway WE. Fulminant hepatic neoplasia after androgen therapy. N Engl J Med. 1977 Jun 16; 296(24):1411-2. PMID: 193011.
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    102. Grota LJ, Ambruso D. The effects of premature delivery on subsequent development of the rat. Dev Psychobiol. 1973 Sep; 6(5):475-80. PMID: 4752877.
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