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Amy S McKee

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
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    R01HL126736     (MCKEE, AMY)Jan 15, 2016 - Dec 31, 2020
    Innate effects of beryllium on pulmonarydendritic cell function in chronic beryllium disease
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wade MF, Collins MK, Richards D, Mack DG, Martin AK, Dinarello CA, Fontenot AP, McKee AS. TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization. J Immunol. 2018 Oct 15; 201(8):2232-2243. PMID: 30185516.
      View in: PubMed
    2. McKee AS, Marrack P. Old and new adjuvants. Curr Opin Immunol. 2017 Aug; 47:44-51. PMID: 28734174.
      View in: PubMed
    3. McKee AS, Fontenot AP. Interplay of innate and adaptive immunity in metal-induced hypersensitivity. Curr Opin Immunol. 2016 10; 42:25-30. PMID: 27228132.
      View in: PubMed
    4. Fontenot AP, Falta MT, Kappler JW, Dai S, McKee AS. Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation. J Immunol. 2016 Jan 01; 196(1):22-7. PMID: 26685315; PMCID: PMC4685955 [Available on 01/01/17].
    5. McKee AS, Mack DG, Crawford F, Fontenot AP. MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4? T-cell priming. Mucosal Immunol. 2015 Nov; 8(6):1237-47. PMID: 25760420; PMCID: PMC4567547.
    6. Mack DG, Falta MT, McKee AS, Martin AK, Simonian PL, Crawford F, Gordon T, Mercer RR, Hoover MD, Marrack P, Kappler JW, Tuder RM, Fontenot AP. Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8553-8. PMID: 24912188.
      View in: PubMed
    7. Dai S, Falta MT, Bowerman NA, McKee AS, Fontenot AP. T cell recognition of beryllium. Curr Opin Immunol. 2013 Dec; 25(6):775-80. PMID: 23978481; PMCID: PMC3883670.
    8. McKee AS, Burchill MA, Munks MW, Jin L, Kappler JW, Friedman RS, Jacobelli J, Marrack P. Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):E1122-31. PMID: 23447566; PMCID: PMC3607057.
    9. Huang Y, Aydintug MK, Loomis J, Macleod MK, McKee AS, Kirchenbaum G, Jakubzick CV, Kedl RM, Sun D, Jacobelli J, O'Brien RL, Born WK. Antigen-specific regulation of IgE antibodies by non-antigen-specific ?d T cells. J Immunol. 2013 Feb 01; 190(3):913-21. PMID: 23275606; PMCID: PMC3552125.
    10. MacLeod MK, McKee AS, David A, Wang J, Mason R, Kappler JW, Marrack P. Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7914-9. PMID: 21518876; PMCID: PMC3093483.
    11. MacLeod MK, David A, McKee AS, Crawford F, Kappler JW, Marrack P. Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. J Immunol. 2011 Mar 01; 186(5):2889-96. PMID: 21270407; PMCID: PMC3069687.
    12. Munks MW, McKee AS, Macleod MK, Powell RL, Degen JL, Reisdorph NA, Kappler JW, Marrack P. Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood. 2010 Dec 09; 116(24):5191-9. PMID: 20876456; PMCID: PMC3012537.
    13. McKee AS, MacLeod MK, Kappler JW, Marrack P. Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biol. 2010 Apr 12; 8:37. PMID: 20385031; PMCID: PMC2864095.
    14. McKee AS, Munks MW, MacLeod MK, Fleenor CJ, Van Rooijen N, Kappler JW, Marrack P. Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol. 2009 Oct 01; 183(7):4403-14. PMID: 19734227; PMCID: PMC2912728.
    15. Marrack P, McKee AS, Munks MW. Towards an understanding of the adjuvant action of aluminium. Nat Rev Immunol. 2009 04; 9(4):287-93. PMID: 19247370; PMCID: PMC3147301.
    16. MacLeod MK, McKee A, Crawford F, White J, Kappler J, Marrack P. CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14521-6. PMID: 18787120; PMCID: PMC2533680.
    17. McKee AS, MacLeod M, White J, Crawford F, Kappler JW, Marrack P. Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses. Int Immunol. 2008 May; 20(5):659-69. PMID: 18343889; PMCID: PMC2935467.
    18. McKee AS, Munks MW, Marrack P. How do adjuvants work? Important considerations for new generation adjuvants. Immunity. 2007 Nov; 27(5):687-90. PMID: 18031690.
      View in: PubMed
    19. Jorgensen TN, McKee A, Wang M, Kushnir E, White J, Refaeli Y, Kappler JW, Marrack P. Bim and Bcl-2 mutually affect the expression of the other in T cells. J Immunol. 2007 Sep 15; 179(6):3417-24. PMID: 17785775.
      View in: PubMed
    20. Kane CM, Cervi L, Sun J, McKee AS, Masek KS, Shapira S, Hunter CA, Pearce EJ. Helminth antigens modulate TLR-initiated dendritic cell activation. J Immunol. 2004 Dec 15; 173(12):7454-61. PMID: 15585871.
      View in: PubMed
    21. Pearce EJ, M Kane C, Sun J, J Taylor J, McKee AS, Cervi L. Th2 response polarization during infection with the helminth parasite Schistosoma mansoni. Immunol Rev. 2004 Oct; 201:117-26. PMID: 15361236.
      View in: PubMed
    22. McKee AS, Dzierszinski F, Boes M, Roos DS, Pearce EJ. Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondii. J Immunol. 2004 Aug 15; 173(4):2632-40. PMID: 15294980.
      View in: PubMed
    23. McKee AS, Pearce EJ. CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol. 2004 Jul 15; 173(2):1224-31. PMID: 15240714.
      View in: PubMed
    24. Straw AD, MacDonald AS, Denkers EY, Pearce EJ. CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses. J Immunol. 2003 Jan 15; 170(2):727-34. PMID: 12517934.
      View in: PubMed
    25. MacDonald AS, Straw AD, Dalton NM, Pearce EJ. Cutting edge: Th2 response induction by dendritic cells: a role for CD40. J Immunol. 2002 Jan 15; 168(2):537-40. PMID: 11777943.
      View in: PubMed
    26. MacDonald AS, Straw AD, Bauman B, Pearce EJ. CD8- dendritic cell activation status plays an integral role in influencing Th2 response development. J Immunol. 2001 Aug 15; 167(4):1982-8. PMID: 11489979.
      View in: PubMed
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