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Leland Shapiro

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/315-3558

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Henao-Martínez AF, Gross L, Mcnair B, McCollister B, DeSanto K, Montoya JG, Shapiro L, Beckham JD. Risk Factors for Cryptococcal Meningitis: A Single United States Center Experience. Mycopathologia. 2016 Dec; 181(11-12):807-814. PMID: 27502502.
      View in: PubMed
    2. Zhou X, Liu Z, Shapiro L, Yang J, Burton GF. Low-density lipoprotein receptor-related protein 1 mediates a1-antitrypsin internalization in CD4+ T lymphocytes. J Leukoc Biol. 2015 Dec; 98(6):1027-35. PMID: 26206901; PMCID: PMC4763795 [Available on 10/01/16].
    3. Yogo N, Shapiro L, Erlandson KM. Sepedonium intra-abdominal infection: a case report and review of an emerging fungal infection. J Antimicrob Chemother. 2014 Sep; 69(9):2583-5. PMID: 24788660.
      View in: PubMed
    4. Gottlieb PA, Alkanani AK, Michels AW, Lewis EC, Shapiro L, Dinarello CA, Zipris D. a1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1ß responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes. J Clin Endocrinol Metab. 2014 Aug; 99(8):E1418-26. PMID: 24527714; PMCID: PMC4121034.
    5. Ferreira TC, Sampaio EP, Argañaraz GA, Gondim MV, Shapiro L, Argañaraz ER. Increased prevalence of the alpha-1-antitrypsin (A1AT) deficiency-related S gene in patients infected with human immunodeficiency virus type 1. J Med Virol. 2014 Jan; 86(1):23-9. PMID: 24122823.
      View in: PubMed
    6. Pott GB, Beard KS, Bryan CL, Merrick DT, Shapiro L. Alpha-1 antitrypsin reduces severity of pseudomonas pneumonia in mice and inhibits epithelial barrier disruption and pseudomonas invasion of respiratory epithelial cells. Front Public Health. 2013; 1:19. PMID: 24350188; PMCID: PMC3854847.
    7. Kartalija M, Ovrutsky AR, Bryan CL, Pott GB, Fantuzzi G, Thomas J, Strand MJ, Bai X, Ramamoorthy P, Rothman MS, Nagabhushanam V, McDermott M, Levin AR, Frazer-Abel A, Giclas PC, Korner J, Iseman MD, Shapiro L, Chan ED. Patients with nontuberculous mycobacterial lung disease exhibit unique body and immune phenotypes. Am J Respir Crit Care Med. 2013 Jan 15; 187(2):197-205. PMID: 23144328.
      View in: PubMed
    8. Chan ED, Pott GB, Silkoff PE, Ralston AH, Bryan CL, Shapiro L. Alpha-1-antitrypsin inhibits nitric oxide production. J Leukoc Biol. 2012 Dec; 92(6):1251-60. PMID: 22975343.
      View in: PubMed
    9. Lee JH, Hanaoka M, Kitaguchi Y, Kraskauskas D, Shapiro L, Voelkel NF, Taraseviciene-Stewart L. Imbalance of apoptosis and cell proliferation contributes to the development and persistence of emphysema. Lung. 2012 Feb; 190(1):69-82. PMID: 22015802.
      View in: PubMed
    10. Zhou X, Shapiro L, Fellingham G, Willardson BM, Burton GF. HIV replication in CD4+ T lymphocytes in the presence and absence of follicular dendritic cells: inhibition of replication mediated by a-1-antitrypsin through altered I?Ba ubiquitination. J Immunol. 2011 Mar 01; 186(5):3148-55. PMID: 21263074; PMCID: PMC3101708.
    11. Bryan CL, Beard KS, Pott GB, Rahkola J, Gardner EM, Janoff EN, Shapiro L. HIV infection is associated with reduced serum alpha-1-antitrypsin concentrations. Clin Invest Med. 2010 Dec 01; 33(6):E384-9. PMID: 21134340.
      View in: PubMed
    12. Hiremath J, Thanikachalam S, Parikh K, Shanmugasundaram S, Bangera S, Shapiro L, Pott GB, Vnencak-Jones CL, Arneson C, Wade M, White RJ. Exercise improvement and plasma biomarker changes with intravenous treprostinil therapy for pulmonary arterial hypertension: a placebo-controlled trial. J Heart Lung Transplant. 2010 Feb; 29(2):137-49. PMID: 20022264.
      View in: PubMed
    13. Pott GB, Chan ED, Dinarello CA, Shapiro L. Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood. J Leukoc Biol. 2009 May; 85(5):886-95. PMID: 19197072; PMCID: PMC2669404.
    14. Lewis EC, Mizrahi M, Toledano M, Defelice N, Wright JL, Churg A, Shapiro L, Dinarello CA. alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16236-41. PMID: 18852465.
      View in: PubMed
    15. Pott GB, Sailer CA, Porat R, Peskind RL, Fuchs AC, Angel JB, Skolnik PR, Jacobson MA, Giordano MF, Lebeaut A, Grint PC, Dinarello CA, Shapiro L. Effect of a four-week course of interleukin-10 on cytokine production in a placebo-controlled study of HIV-1-infected subjects. Eur Cytokine Netw. 2007 Jun; 18(2):49-58. PMID: 17594937.
      View in: PubMed
    16. Sailer CA, Pott GB, Dinarello CA, Whinney SM, Forster JE, Larson-Duran JK, Landay A, Al-Harthi L, Schooley RT, Benson CA, Judson FN, Thompson M, Palella FJ, Shapiro L. Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels. J Infect Dis. 2007 Mar 01; 195(5):734-8. PMID: 17262717.
      View in: PubMed
    17. Chan ED, Kaminska AM, Gill W, Chmura K, Feldman NE, Bai X, Floyd CM, Fulton KE, Huitt GA, Strand MJ, Iseman MD, Shapiro L. Alpha-1-antitrypsin (AAT) anomalies are associated with lung disease due to rapidly growing mycobacteria and AAT inhibits Mycobacterium abscessus infection of macrophages. Scand J Infect Dis. 2007; 39(8):690-6. PMID: 17654345.
      View in: PubMed
    18. Lewis EC, Shapiro L, Bowers OJ, Dinarello CA. Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12153-8. PMID: 16093309; PMCID: PMC1189344.
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